Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast
Across species, the skeletal system shares mutual functions, including the protection of inner organs, structural basis for locomotion, and acting as an endocrine organ, thus being of pivotal importance for survival. However, insights into skeletal characteristics of marine mammals are limited, espe...
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ftpubmed:oai:pubmedcentral.nih.gov:10156659 2023-06-11T04:16:00+02:00 Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast Delsmann, Julian Schmidt, Britta Oheim, Ralf Amling, Michael Rolvien, Tim Siebert, Ursula 2023-05-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156659/ http://www.ncbi.nlm.nih.gov/pubmed/37137898 https://doi.org/10.1038/s41598-023-33911-8 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156659/ http://www.ncbi.nlm.nih.gov/pubmed/37137898 http://dx.doi.org/10.1038/s41598-023-33911-8 © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . Sci Rep Article Text 2023 ftpubmed https://doi.org/10.1038/s41598-023-33911-8 2023-05-07T01:26:50Z Across species, the skeletal system shares mutual functions, including the protection of inner organs, structural basis for locomotion, and acting as an endocrine organ, thus being of pivotal importance for survival. However, insights into skeletal characteristics of marine mammals are limited, especially in the growing skeleton. Harbor seals (Phoca vitulina) are common marine mammals in the North and Baltic Seas and are suitable indicators of the condition of their ecosystem. Here, we analyzed whole-body areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) and lumbar vertebrae by high-resolution peripheral quantitative computed tomography (HR-pQCT) in neonate, juvenile, and adult harbor seals. Along skeletal growth, an increase in two-dimensional aBMD by DXA was paralleled by three-dimensional volumetric BMD by HR-pQCT, which could be attributed to an increasing trabecular thickness while trabecular number remained constant. Strong associations were observed between body dimensions (weight and length) and aBMD and trabecular microarchitecture (R(2) = 0.71–0.92, all p < 0.001). To validate the results of the DXA measurement (i.e., the standard method used worldwide to diagnose osteoporosis in humans), we performed linear regression analyses with the three-dimensional measurements from the HR-pQCT method, which revealed strong associations between the two imaging techniques (e.g., aBMD and Tb.Th: R(2) = 0.96, p < 0.0001). Taken together, our findings highlight the importance of systematic skeletal investigations in marine mammals during growth, illustrating the high accuracy of DXA in this context. Regardless of the limited sample size, the observed trabecular thickening is likely to represent a distinct pattern of vertebral bone maturation. As differences in nutritional status, among other factors, are likely to affect skeletal health, it appears essential to routinely perform skeletal assessments in marine mammals. Placing the results in the context of environmental exposures may ... Text Phoca vitulina PubMed Central (PMC) Scientific Reports 13 1 |
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Article Delsmann, Julian Schmidt, Britta Oheim, Ralf Amling, Michael Rolvien, Tim Siebert, Ursula Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
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description |
Across species, the skeletal system shares mutual functions, including the protection of inner organs, structural basis for locomotion, and acting as an endocrine organ, thus being of pivotal importance for survival. However, insights into skeletal characteristics of marine mammals are limited, especially in the growing skeleton. Harbor seals (Phoca vitulina) are common marine mammals in the North and Baltic Seas and are suitable indicators of the condition of their ecosystem. Here, we analyzed whole-body areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) and lumbar vertebrae by high-resolution peripheral quantitative computed tomography (HR-pQCT) in neonate, juvenile, and adult harbor seals. Along skeletal growth, an increase in two-dimensional aBMD by DXA was paralleled by three-dimensional volumetric BMD by HR-pQCT, which could be attributed to an increasing trabecular thickness while trabecular number remained constant. Strong associations were observed between body dimensions (weight and length) and aBMD and trabecular microarchitecture (R(2) = 0.71–0.92, all p < 0.001). To validate the results of the DXA measurement (i.e., the standard method used worldwide to diagnose osteoporosis in humans), we performed linear regression analyses with the three-dimensional measurements from the HR-pQCT method, which revealed strong associations between the two imaging techniques (e.g., aBMD and Tb.Th: R(2) = 0.96, p < 0.0001). Taken together, our findings highlight the importance of systematic skeletal investigations in marine mammals during growth, illustrating the high accuracy of DXA in this context. Regardless of the limited sample size, the observed trabecular thickening is likely to represent a distinct pattern of vertebral bone maturation. As differences in nutritional status, among other factors, are likely to affect skeletal health, it appears essential to routinely perform skeletal assessments in marine mammals. Placing the results in the context of environmental exposures may ... |
format |
Text |
author |
Delsmann, Julian Schmidt, Britta Oheim, Ralf Amling, Michael Rolvien, Tim Siebert, Ursula |
author_facet |
Delsmann, Julian Schmidt, Britta Oheim, Ralf Amling, Michael Rolvien, Tim Siebert, Ursula |
author_sort |
Delsmann, Julian |
title |
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
title_short |
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
title_full |
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
title_fullStr |
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
title_full_unstemmed |
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast |
title_sort |
bone mineral density and microarchitecture change during skeletal growth in harbor seals (phoca vitulina) from the german coast |
publisher |
Nature Publishing Group UK |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156659/ http://www.ncbi.nlm.nih.gov/pubmed/37137898 https://doi.org/10.1038/s41598-023-33911-8 |
genre |
Phoca vitulina |
genre_facet |
Phoca vitulina |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156659/ http://www.ncbi.nlm.nih.gov/pubmed/37137898 http://dx.doi.org/10.1038/s41598-023-33911-8 |
op_rights |
© The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_doi |
https://doi.org/10.1038/s41598-023-33911-8 |
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Scientific Reports |
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13 |
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