Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values
BACKGROUND: Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compa...
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ftpubmed:oai:pubmedcentral.nih.gov:10077603 2023-05-15T17:44:32+02:00 Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values Erelund, Sofia Karp, Kjell Arvidsson, Sandra Johansson, Bengt Sundström, Nina Wiklund, Urban 2023-04-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077603/ http://www.ncbi.nlm.nih.gov/pubmed/37020237 https://doi.org/10.1186/s12890-023-02403-w en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077603/ http://www.ncbi.nlm.nih.gov/pubmed/37020237 http://dx.doi.org/10.1186/s12890-023-02403-w © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. BMC Pulm Med Research Text 2023 ftpubmed https://doi.org/10.1186/s12890-023-02403-w 2023-04-09T01:07:15Z BACKGROUND: Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects. METHODS: The study population consisted of 285 healthy adults (148 males, 52%) between 20–90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model. RESULTS: No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV(1) (forced expiratory volume) and FVC (forced vital capacity), and consequently fewer subjects below the lower limit of normality, than both the rederived LMS and OLIN models. CONCLUSIONS: Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in ... Text Northern Sweden Norrbotten PubMed Central (PMC) BMC Pulmonary Medicine 23 1 |
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Research Erelund, Sofia Karp, Kjell Arvidsson, Sandra Johansson, Bengt Sundström, Nina Wiklund, Urban Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
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Research |
description |
BACKGROUND: Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects. METHODS: The study population consisted of 285 healthy adults (148 males, 52%) between 20–90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model. RESULTS: No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV(1) (forced expiratory volume) and FVC (forced vital capacity), and consequently fewer subjects below the lower limit of normality, than both the rederived LMS and OLIN models. CONCLUSIONS: Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in ... |
format |
Text |
author |
Erelund, Sofia Karp, Kjell Arvidsson, Sandra Johansson, Bengt Sundström, Nina Wiklund, Urban |
author_facet |
Erelund, Sofia Karp, Kjell Arvidsson, Sandra Johansson, Bengt Sundström, Nina Wiklund, Urban |
author_sort |
Erelund, Sofia |
title |
Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
title_short |
Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
title_full |
Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
title_fullStr |
Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
title_full_unstemmed |
Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden—a comparison with discordant reference values |
title_sort |
pulmonary function in a cohort of heart-healthy individuals from northern sweden—a comparison with discordant reference values |
publisher |
BioMed Central |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077603/ http://www.ncbi.nlm.nih.gov/pubmed/37020237 https://doi.org/10.1186/s12890-023-02403-w |
genre |
Northern Sweden Norrbotten |
genre_facet |
Northern Sweden Norrbotten |
op_source |
BMC Pulm Med |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077603/ http://www.ncbi.nlm.nih.gov/pubmed/37020237 http://dx.doi.org/10.1186/s12890-023-02403-w |
op_rights |
© The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
op_doi |
https://doi.org/10.1186/s12890-023-02403-w |
container_title |
BMC Pulmonary Medicine |
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23 |
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