Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease
Spectral tuning of visual pigments often facilitates adaptation to new environments, and it is intriguing to study the visual ecology of pelagic sharks with secondarily expanded habitats. The whale shark, which dives into the deep sea of nearly 2,000 meters besides near-surface filter feeding, was p...
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ftpubmed:oai:pubmedcentral.nih.gov:10068813 2023-05-15T14:13:28+02:00 Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease Yamaguchi, Kazuaki Koyanagi, Mitsumasa Sato, Keiichi Terakita, Akihisa Kuraku, Shigehiro 2023-03-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068813/ http://www.ncbi.nlm.nih.gov/pubmed/36943890 https://doi.org/10.1073/pnas.2220728120 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068813/ http://www.ncbi.nlm.nih.gov/pubmed/36943890 http://dx.doi.org/10.1073/pnas.2220728120 Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . Proc Natl Acad Sci U S A Biological Sciences Text 2023 ftpubmed https://doi.org/10.1073/pnas.2220728120 2023-04-09T00:46:58Z Spectral tuning of visual pigments often facilitates adaptation to new environments, and it is intriguing to study the visual ecology of pelagic sharks with secondarily expanded habitats. The whale shark, which dives into the deep sea of nearly 2,000 meters besides near-surface filter feeding, was previously shown to possess the ‘blue-shifted’ rhodopsin (RHO), which is a signature of deep-sea adaptation. In this study, our spectroscopy of recombinant whale shark RHO mutants revealed that this blue shift is caused dominantly by an unprecedented spectral tuning site 94. In humans, the mutation at the site causes congenital stationary night blindness (CSNB) by reducing the thermal stability of RHO. Similarly, the RHO of deep-diving whale shark has reduced thermal stability, which was experimentally shown to be achieved by site 178 and 94. RHOs having the natural substitution at site 94 are also found in some Antarctic fishes, suggesting that the blue shift by the substitution at the CSNB site associated with the reduction in thermal stability might be allowed in cold-water deep-sea habitats. Text Antarc* Antarctic PubMed Central (PMC) Antarctic Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) Proceedings of the National Academy of Sciences 120 13 |
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Biological Sciences |
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Biological Sciences Yamaguchi, Kazuaki Koyanagi, Mitsumasa Sato, Keiichi Terakita, Akihisa Kuraku, Shigehiro Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
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Biological Sciences |
description |
Spectral tuning of visual pigments often facilitates adaptation to new environments, and it is intriguing to study the visual ecology of pelagic sharks with secondarily expanded habitats. The whale shark, which dives into the deep sea of nearly 2,000 meters besides near-surface filter feeding, was previously shown to possess the ‘blue-shifted’ rhodopsin (RHO), which is a signature of deep-sea adaptation. In this study, our spectroscopy of recombinant whale shark RHO mutants revealed that this blue shift is caused dominantly by an unprecedented spectral tuning site 94. In humans, the mutation at the site causes congenital stationary night blindness (CSNB) by reducing the thermal stability of RHO. Similarly, the RHO of deep-diving whale shark has reduced thermal stability, which was experimentally shown to be achieved by site 178 and 94. RHOs having the natural substitution at site 94 are also found in some Antarctic fishes, suggesting that the blue shift by the substitution at the CSNB site associated with the reduction in thermal stability might be allowed in cold-water deep-sea habitats. |
format |
Text |
author |
Yamaguchi, Kazuaki Koyanagi, Mitsumasa Sato, Keiichi Terakita, Akihisa Kuraku, Shigehiro |
author_facet |
Yamaguchi, Kazuaki Koyanagi, Mitsumasa Sato, Keiichi Terakita, Akihisa Kuraku, Shigehiro |
author_sort |
Yamaguchi, Kazuaki |
title |
Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
title_short |
Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
title_full |
Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
title_fullStr |
Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
title_full_unstemmed |
Whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
title_sort |
whale shark rhodopsin adapted to deep-sea lifestyle by a substitution associated with human disease |
publisher |
National Academy of Sciences |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068813/ http://www.ncbi.nlm.nih.gov/pubmed/36943890 https://doi.org/10.1073/pnas.2220728120 |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Antarctic Rho |
geographic_facet |
Antarctic Rho |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Proc Natl Acad Sci U S A |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068813/ http://www.ncbi.nlm.nih.gov/pubmed/36943890 http://dx.doi.org/10.1073/pnas.2220728120 |
op_rights |
Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
op_doi |
https://doi.org/10.1073/pnas.2220728120 |
container_title |
Proceedings of the National Academy of Sciences |
container_volume |
120 |
container_issue |
13 |
_version_ |
1766285936795058176 |