Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study
OBJECTIVE: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. METHODS: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were id...
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ftpubmed:oai:pubmedcentral.nih.gov:10068519 2023-05-15T17:44:55+02:00 Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study Dehara, Marina Sachs, Michael C. Grunewald, Johan Blomberg, Anders Arkema, Elizabeth V. 2023-04-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068519/ http://www.ncbi.nlm.nih.gov/pubmed/37020842 https://doi.org/10.1183/23120541.00492-2022 en eng European Respiratory Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068519/ http://www.ncbi.nlm.nih.gov/pubmed/37020842 http://dx.doi.org/10.1183/23120541.00492-2022 Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) ERJ Open Res Original Research Articles Text 2023 ftpubmed https://doi.org/10.1183/23120541.00492-2022 2023-04-09T00:46:09Z OBJECTIVE: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. METHODS: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identified via medical records and matched to controls (n=660) on sub-cohort, sex, birth and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95% CI). RESULTS: Compared with never-smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95% CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95% CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34; 95% CI 0.94–1.92) but not with overweight (aOR 0.99; 95% CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds of sarcoidosis (aOR 1.25; 95% CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95% CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. CONCLUSION: We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active. Text Northern Sweden PubMed Central (PMC) ERJ Open Research 9 2 00492-2022 |
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Original Research Articles Dehara, Marina Sachs, Michael C. Grunewald, Johan Blomberg, Anders Arkema, Elizabeth V. Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
topic_facet |
Original Research Articles |
description |
OBJECTIVE: We aimed to investigate whether obesity, tobacco use, alcohol consumption and physical inactivity are associated with sarcoidosis risk. METHODS: We conducted a matched case–control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identified via medical records and matched to controls (n=660) on sub-cohort, sex, birth and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95% CI). RESULTS: Compared with never-smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95% CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95% CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34; 95% CI 0.94–1.92) but not with overweight (aOR 0.99; 95% CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds of sarcoidosis (aOR 1.25; 95% CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95% CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. CONCLUSION: We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active. |
format |
Text |
author |
Dehara, Marina Sachs, Michael C. Grunewald, Johan Blomberg, Anders Arkema, Elizabeth V. |
author_facet |
Dehara, Marina Sachs, Michael C. Grunewald, Johan Blomberg, Anders Arkema, Elizabeth V. |
author_sort |
Dehara, Marina |
title |
Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
title_short |
Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
title_full |
Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
title_fullStr |
Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
title_full_unstemmed |
Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
title_sort |
modifiable lifestyle risk factors for sarcoidosis: a nested case–control study |
publisher |
European Respiratory Society |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068519/ http://www.ncbi.nlm.nih.gov/pubmed/37020842 https://doi.org/10.1183/23120541.00492-2022 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
ERJ Open Res |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068519/ http://www.ncbi.nlm.nih.gov/pubmed/37020842 http://dx.doi.org/10.1183/23120541.00492-2022 |
op_rights |
Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
op_doi |
https://doi.org/10.1183/23120541.00492-2022 |
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ERJ Open Research |
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9 |
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2 |
container_start_page |
00492-2022 |
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1766147227242201088 |