The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland
The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinin...
Published in: | International Journal of Circumpolar Health |
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2023
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035948/ http://www.ncbi.nlm.nih.gov/pubmed/36944026 https://doi.org/10.1080/22423982.2023.2191406 |
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ftpubmed:oai:pubmedcentral.nih.gov:10035948 2023-05-15T15:55:24+02:00 The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika 2023-03-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035948/ http://www.ncbi.nlm.nih.gov/pubmed/36944026 https://doi.org/10.1080/22423982.2023.2191406 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035948/ http://www.ncbi.nlm.nih.gov/pubmed/36944026 http://dx.doi.org/10.1080/22423982.2023.2191406 © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. Int J Circumpolar Health Research Article Text 2023 ftpubmed https://doi.org/10.1080/22423982.2023.2191406 2023-03-26T02:21:00Z The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m(2)), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies. Text Circumpolar Health Greenland greenlander* inuit PubMed Central (PMC) Greenland International Journal of Circumpolar Health 82 1 |
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Research Article |
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Research Article Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
topic_facet |
Research Article |
description |
The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m(2)), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies. |
format |
Text |
author |
Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika |
author_facet |
Overvad, Maria Díaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Grarup, Niels Hansen, Torben Rossing, Peter Jørgensen, Marit Eika |
author_sort |
Overvad, Maria |
title |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_short |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_full |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_fullStr |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_full_unstemmed |
The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland |
title_sort |
effect of diabetes and the diabetogenic tbc1d4 p.arg684ter variant on kidney function in inuit in greenland |
publisher |
Taylor & Francis |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035948/ http://www.ncbi.nlm.nih.gov/pubmed/36944026 https://doi.org/10.1080/22423982.2023.2191406 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Circumpolar Health Greenland greenlander* inuit |
genre_facet |
Circumpolar Health Greenland greenlander* inuit |
op_source |
Int J Circumpolar Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035948/ http://www.ncbi.nlm.nih.gov/pubmed/36944026 http://dx.doi.org/10.1080/22423982.2023.2191406 |
op_rights |
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
op_doi |
https://doi.org/10.1080/22423982.2023.2191406 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
_version_ |
1766390893234880512 |