Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the Homes of Asthmatic and Non-asthmatic Children in New York City

• Published in: Journal of Exposure Science & Environmental Epidemiology
• Main Authors: Rush, Rachael E., Dannemiller, Karen C., Cochran, Samuel J., Haines, Sarah R., Acosta, Luis, Divjan, Adnan, Rundle, Andrew G., Miller, Rachel L., Perzanowski, Matthew S., Croston, Tara L., Green, Brett J.
• Format: Text
• Language: English
• Published: 2022
• Subjects: Article; Cryptococcus victoriae
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10032026/; http://www.ncbi.nlm.nih.gov/pubmed/34091598; https://doi.org/10.1038/s41370-021-00342-4

BACKGROUND: Indoor environments contain a broad diversity of non-pathogenic Basidiomycota yeasts, but their role in exacerbating adverse health effects has remained unclear. OBJECTIVE: To understand the role of Vishniacozyma victoriae exposure and its impact on human health. METHODS: A qPCR assay was developed to detect and quantify an abundant indoor yeast species, Vishniacozyma victoriae (syn. Cryptococcus victoriae), from homes participating in the New York City Neighborhood Asthma and Allergy Study (NAAS). We evaluated the associations between V. victoriae, housing characteristics, and asthma relevant health endpoints. RESULTS: V. victoriae was quantified in 236 of the 256 bedroom floor dust samples ranging from less than 300 to 45,918 cell equivalents/mg of dust. Higher concentrations of V. victoriae were significantly associated with carpeted bedroom floors (P=0.044), mean specific humidity (P=0.004), winter (P<0.0001) and spring (P=0.001) seasons, and the presence of dog (P=0.010) and dog allergen Can f 1 (P=0.027). V. victoriae concentrations were lower in homes of children with asthma vs. without asthma (P=0.027), an association observed only among the non-seroatopic children. SIGNIFICANCE: These findings add to the inverse associations observed between microbial exposures in homes and asthma outcomes in children, specifically the contribution of non-pathogenic Basidiomycota yeasts.