Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

• Published in: Frontiers in Medicine
• Main Authors: Vasilyeva, Irina A., Aksenova, Valentina A., Kazakov, Alexey V., Kiseleva, Yulia Y., Maryandyshev, Andrey O., Dolzhenko, Elena N., Abramchenko, Anna V., Klevno, Nadejda I., Glebov, Konstantin A., Panova, Anna E., Petrova, Larisa Y., Sheikis, Elena G., Seregina, Inna V., Nikishova, Elena I., Doktorova, Natalia P., Samoilova, Anastasia G.
• Format: Text
• Language: English
• Published: Frontiers Media S.A. 2023
• Subjects: Medicine; Calmette; Arkhangelsk
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014891/; https://doi.org/10.3389/fmed.2023.1042461

INTRODUCTION: The tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible...