Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups
Tuvans are one of the most compactly living peoples of Southern Siberia, settled mainly in the territory of Tuva. The gene pool of the Tuvans is quite isolated, due to endogamy and a very low frequency of interethnic marriages. The structure of the gene pool of the Tuvans and other Siberian populati...
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The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
2023
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009474/ http://www.ncbi.nlm.nih.gov/pubmed/36923480 https://doi.org/10.18699/VJGB-23-06 |
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ftpubmed:oai:pubmedcentral.nih.gov:10009474 2023-05-15T16:09:14+02:00 Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups Stepanov, V.A. Kolesnikov, N.A. Valikhova, L.V. Zarubin, A.A. Khitrinskaya, I.Yu. Kharkov, V.N. 2023-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009474/ http://www.ncbi.nlm.nih.gov/pubmed/36923480 https://doi.org/10.18699/VJGB-23-06 en eng The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009474/ http://www.ncbi.nlm.nih.gov/pubmed/36923480 http://dx.doi.org/10.18699/VJGB-23-06 Copyright © AUTHORS https://creativecommons.org/licenses/by/2.5/This work is licensed under a Creative Commons Attribution 4.0 License Vavilovskii Zhurnal Genet Selektsii Original Article Text 2023 ftpubmed https://doi.org/10.18699/VJGB-23-06 2023-03-19T01:49:26Z Tuvans are one of the most compactly living peoples of Southern Siberia, settled mainly in the territory of Tuva. The gene pool of the Tuvans is quite isolated, due to endogamy and a very low frequency of interethnic marriages. The structure of the gene pool of the Tuvans and other Siberian populations was studied using a genome-wide panel of autosomal single nucleotide polymorphic markers and Y-chromosome markers. The results of the analysis of the frequencies of autosomal SNPs by various methods, the similarities in the composition of the Y-chromosome haplogroups and YSTR haplotypes show that the gene pool of the Tuvans is very heterogeneous in terms of the composition of genetic components. It includes the ancient autochthonous Yeniseian component, which dominates among the Chulym Turks and Kets, the East Siberian component, which prevails among the Yakuts and Evenks, and the Far Eastern component, the frequency of which is maximum among the Nivkhs and Udeges. Analysis of the composition of IBD-blocks on autosomes shows the maximum genetic relationship of the Tuvans with the Southern Altaians, Khakas and Shors, who were formed during the settlement of the Turkic groups of populations on the territory of the Altai-Sayan region. A very diverse composition of the Tuvan gene pool is shown for various sublines of Y-chromosomal haplogroups, most of which show strong ethnic specificity. Phylogenetic analysis of individual Y-chromosome haplogroups demonstrates the maximum proximity of the gene pool of the Tuvans with the Altaians, Khakas and Shors. Differences in frequencies of Y-chromosome haplogroups between the Todzhans and Tuvans and a change in the frequencies of haplogroups from south to north associated with the East Asian component were found. The majority of the most frequent Y-chromosome haplogroups in the Tuvans demonstrate the founder effect, the formation age of which is fully consistent with the data on their ethnogenesis. Text Evenks Yakuts Siberia PubMed Central (PMC) The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Tuva ENVELOPE(12.506,12.506,65.215,65.215) Vavilov Journal of Genetics and Breeding 27 1 36 45 |
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Original Article |
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Original Article Stepanov, V.A. Kolesnikov, N.A. Valikhova, L.V. Zarubin, A.A. Khitrinskaya, I.Yu. Kharkov, V.N. Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
topic_facet |
Original Article |
description |
Tuvans are one of the most compactly living peoples of Southern Siberia, settled mainly in the territory of Tuva. The gene pool of the Tuvans is quite isolated, due to endogamy and a very low frequency of interethnic marriages. The structure of the gene pool of the Tuvans and other Siberian populations was studied using a genome-wide panel of autosomal single nucleotide polymorphic markers and Y-chromosome markers. The results of the analysis of the frequencies of autosomal SNPs by various methods, the similarities in the composition of the Y-chromosome haplogroups and YSTR haplotypes show that the gene pool of the Tuvans is very heterogeneous in terms of the composition of genetic components. It includes the ancient autochthonous Yeniseian component, which dominates among the Chulym Turks and Kets, the East Siberian component, which prevails among the Yakuts and Evenks, and the Far Eastern component, the frequency of which is maximum among the Nivkhs and Udeges. Analysis of the composition of IBD-blocks on autosomes shows the maximum genetic relationship of the Tuvans with the Southern Altaians, Khakas and Shors, who were formed during the settlement of the Turkic groups of populations on the territory of the Altai-Sayan region. A very diverse composition of the Tuvan gene pool is shown for various sublines of Y-chromosomal haplogroups, most of which show strong ethnic specificity. Phylogenetic analysis of individual Y-chromosome haplogroups demonstrates the maximum proximity of the gene pool of the Tuvans with the Altaians, Khakas and Shors. Differences in frequencies of Y-chromosome haplogroups between the Todzhans and Tuvans and a change in the frequencies of haplogroups from south to north associated with the East Asian component were found. The majority of the most frequent Y-chromosome haplogroups in the Tuvans demonstrate the founder effect, the formation age of which is fully consistent with the data on their ethnogenesis. |
format |
Text |
author |
Stepanov, V.A. Kolesnikov, N.A. Valikhova, L.V. Zarubin, A.A. Khitrinskaya, I.Yu. Kharkov, V.N. |
author_facet |
Stepanov, V.A. Kolesnikov, N.A. Valikhova, L.V. Zarubin, A.A. Khitrinskaya, I.Yu. Kharkov, V.N. |
author_sort |
Stepanov, V.A. |
title |
Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
title_short |
Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
title_full |
Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
title_fullStr |
Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
title_full_unstemmed |
Structure and origin of Tuvan gene pool according to autosome SNP and Y-chromosome haplogroups |
title_sort |
structure and origin of tuvan gene pool according to autosome snp and y-chromosome haplogroups |
publisher |
The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009474/ http://www.ncbi.nlm.nih.gov/pubmed/36923480 https://doi.org/10.18699/VJGB-23-06 |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) ENVELOPE(12.506,12.506,65.215,65.215) |
geographic |
The ''Y'' Tuva |
geographic_facet |
The ''Y'' Tuva |
genre |
Evenks Yakuts Siberia |
genre_facet |
Evenks Yakuts Siberia |
op_source |
Vavilovskii Zhurnal Genet Selektsii |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009474/ http://www.ncbi.nlm.nih.gov/pubmed/36923480 http://dx.doi.org/10.18699/VJGB-23-06 |
op_rights |
Copyright © AUTHORS https://creativecommons.org/licenses/by/2.5/This work is licensed under a Creative Commons Attribution 4.0 License |
op_doi |
https://doi.org/10.18699/VJGB-23-06 |
container_title |
Vavilov Journal of Genetics and Breeding |
container_volume |
27 |
container_issue |
1 |
container_start_page |
36 |
op_container_end_page |
45 |
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1766405156479434752 |