Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study
INTRODUCTION: To explore the role of maternal anthropometric characteristics in early‐pregnancy glycemia, we analyzed the associations and interactions of maternal early‐pregnancy waist circumference (WC), height and pre‐pregnancy body mass index (BMI) with plasma glucose concentrations in an oral g...
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2023
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008291/ http://www.ncbi.nlm.nih.gov/pubmed/36799298 https://doi.org/10.1111/aogs.14528 |
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ftpubmed:oai:pubmedcentral.nih.gov:10008291 2023-05-15T17:00:25+02:00 Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study Jokelainen, Mervi Stach‐Lempinen, Beata Teramo, Kari Nenonen, Arja Kautiainen, Hannu Klemetti, Miira M. 2023-02-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008291/ http://www.ncbi.nlm.nih.gov/pubmed/36799298 https://doi.org/10.1111/aogs.14528 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008291/ http://www.ncbi.nlm.nih.gov/pubmed/36799298 http://dx.doi.org/10.1111/aogs.14528 © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. Acta Obstet Gynecol Scand Perinatology Text 2023 ftpubmed https://doi.org/10.1111/aogs.14528 2023-03-19T01:46:04Z INTRODUCTION: To explore the role of maternal anthropometric characteristics in early‐pregnancy glycemia, we analyzed the associations and interactions of maternal early‐pregnancy waist circumference (WC), height and pre‐pregnancy body mass index (BMI) with plasma glucose concentrations in an oral glucose tolerance test (OGTT) at 12–16 weeks’ gestation. MATERIAL AND METHODS: A population‐based cohort of 1361 pregnant women was recruited in South Karelia, Finland, from March 2013 to December 2016. All participants had their WC, weight, height, HbA(1c), and blood pressure measured at 8–14 weeks’ gestation and subsequently underwent a 2‐h 75‐g OGTT, including assessment of fasting insulin concentrations, at 12–16 weeks’ gestation. BMI (kg/m(2)) was calculated using self‐reported pre‐pregnancy weight. Maternal WC ≥80 cm was defined as large. Maternal height ≥166 cm was defined as tall. Data on gestational diabetes treatment was extracted from hospital records. RESULTS: In the total cohort, 901 (66%) of women had an early‐pregnancy WC ≥80 cm, which was associated with higher early‐pregnancy HbA(1c,) higher concentrations of fasting plasma glucose and serum insulin, higher post‐load plasma glucose concentrations, higher HOMA‐IR indices, higher blood pressure levels, and higher frequencies of pharmacologically treated gestational diabetes, than early‐pregnancy WC <80 cm. Maternal height ≥166 cm was negatively associated with 1‐ and 2‐h post‐load plasma glucose concentrations. Waist‐to‐height ratio (WHtR) >0.5 was positively associated with both fasting and post‐load plasma glucose concentrations at 12–16 weeks’ gestation, even when adjusted for age, smoking, nulliparity, and family history of type 2 diabetes. The best cut‐offs for WHtR (0.58 for 1‐h plasma glucose, and 0.54 for 2‐h plasma glucose) were better predictors of post‐load glucose concentrations >90th percentile than the best cut‐offs for BMI (28.1 kg/m(2) for 1‐h plasma glucose, and 26.6 kg/m(2) for 2‐h plasma glucose), with areas‐under‐the‐curve ... Text karelia* PubMed Central (PMC) Acta Obstetricia et Gynecologica Scandinavica 102 4 496 505 |
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Perinatology |
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Perinatology Jokelainen, Mervi Stach‐Lempinen, Beata Teramo, Kari Nenonen, Arja Kautiainen, Hannu Klemetti, Miira M. Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
topic_facet |
Perinatology |
description |
INTRODUCTION: To explore the role of maternal anthropometric characteristics in early‐pregnancy glycemia, we analyzed the associations and interactions of maternal early‐pregnancy waist circumference (WC), height and pre‐pregnancy body mass index (BMI) with plasma glucose concentrations in an oral glucose tolerance test (OGTT) at 12–16 weeks’ gestation. MATERIAL AND METHODS: A population‐based cohort of 1361 pregnant women was recruited in South Karelia, Finland, from March 2013 to December 2016. All participants had their WC, weight, height, HbA(1c), and blood pressure measured at 8–14 weeks’ gestation and subsequently underwent a 2‐h 75‐g OGTT, including assessment of fasting insulin concentrations, at 12–16 weeks’ gestation. BMI (kg/m(2)) was calculated using self‐reported pre‐pregnancy weight. Maternal WC ≥80 cm was defined as large. Maternal height ≥166 cm was defined as tall. Data on gestational diabetes treatment was extracted from hospital records. RESULTS: In the total cohort, 901 (66%) of women had an early‐pregnancy WC ≥80 cm, which was associated with higher early‐pregnancy HbA(1c,) higher concentrations of fasting plasma glucose and serum insulin, higher post‐load plasma glucose concentrations, higher HOMA‐IR indices, higher blood pressure levels, and higher frequencies of pharmacologically treated gestational diabetes, than early‐pregnancy WC <80 cm. Maternal height ≥166 cm was negatively associated with 1‐ and 2‐h post‐load plasma glucose concentrations. Waist‐to‐height ratio (WHtR) >0.5 was positively associated with both fasting and post‐load plasma glucose concentrations at 12–16 weeks’ gestation, even when adjusted for age, smoking, nulliparity, and family history of type 2 diabetes. The best cut‐offs for WHtR (0.58 for 1‐h plasma glucose, and 0.54 for 2‐h plasma glucose) were better predictors of post‐load glucose concentrations >90th percentile than the best cut‐offs for BMI (28.1 kg/m(2) for 1‐h plasma glucose, and 26.6 kg/m(2) for 2‐h plasma glucose), with areas‐under‐the‐curve ... |
format |
Text |
author |
Jokelainen, Mervi Stach‐Lempinen, Beata Teramo, Kari Nenonen, Arja Kautiainen, Hannu Klemetti, Miira M. |
author_facet |
Jokelainen, Mervi Stach‐Lempinen, Beata Teramo, Kari Nenonen, Arja Kautiainen, Hannu Klemetti, Miira M. |
author_sort |
Jokelainen, Mervi |
title |
Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
title_short |
Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
title_full |
Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
title_fullStr |
Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
title_full_unstemmed |
Large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: A population‐based study |
title_sort |
large maternal waist circumference in relation to height is associated with high glucose concentrations in an early‐pregnancy oral glucose tolerance test: a population‐based study |
publisher |
John Wiley and Sons Inc. |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008291/ http://www.ncbi.nlm.nih.gov/pubmed/36799298 https://doi.org/10.1111/aogs.14528 |
genre |
karelia* |
genre_facet |
karelia* |
op_source |
Acta Obstet Gynecol Scand |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008291/ http://www.ncbi.nlm.nih.gov/pubmed/36799298 http://dx.doi.org/10.1111/aogs.14528 |
op_rights |
© 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
op_doi |
https://doi.org/10.1111/aogs.14528 |
container_title |
Acta Obstetricia et Gynecologica Scandinavica |
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102 |
container_issue |
4 |
container_start_page |
496 |
op_container_end_page |
505 |
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