Exploration of Response Mechanisms in the Gills of Pacific Oyster (
Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their molecular response to acute Cd exposure remain unclear. In this study, the Pacific oyster Crassostrea gigas was used as a biological model, exposed to acute Cd stress...
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Online Access: | https://doi.org/10.3390/ani14162318 https://pubmed.ncbi.nlm.nih.gov/39199852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350665/ |
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ftpubmed:39199852 2024-09-30T14:33:56+00:00 Exploration of Response Mechanisms in the Gills of Pacific Oyster ( Dong, Luyao Sun, Yanan Chu, Muyang Xie, Yuxin Wang, Pinyi Li, Bin Li, Zan Xu, Xiaohui Feng, Yanwei Sun, Guohua Wang, Zhongping Cui, Cuiju Wang, Weijun Yang, Jianmin 2024 Aug 09 https://doi.org/10.3390/ani14162318 https://pubmed.ncbi.nlm.nih.gov/39199852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350665/ eng eng MDPI https://doi.org/10.3390/ani14162318 https://pubmed.ncbi.nlm.nih.gov/39199852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350665/ Animals (Basel) ISSN:2076-2615 Volume:14 Issue:16 Crassostrea gigas cadmium stress energy metabolism metabolomic transcriptomic Journal Article 2024 ftpubmed https://doi.org/10.3390/ani14162318 2024-09-01T16:02:00Z Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their molecular response to acute Cd exposure remain unclear. In this study, the Pacific oyster Crassostrea gigas was used as a biological model, exposed to acute Cd stress for 96 h. Transcriptomic analyses of their gills were performed, and metabolomic analyses further validated these results. In our study, a total of 111 differentially expressed metabolites (DEMs) and 2108 differentially expressed genes (DEGs) were identified under acute Cd exposure. Further analyses revealed alterations in key genes and metabolic pathways associated with heavy metal stress response. Cd exposure triggered physiological and metabolic responses in oysters, including enhanced oxidative stress and disturbances in energy metabolism, and these changes revealed the biological response of oysters to acute Cd stress. Moreover, oysters could effectively enhance the tolerance and detoxification ability to acute Cd exposure through activating ABC transporters, enhancing glutathione metabolism and sulfur relay system in gill cells, and regulating energy metabolism. This study reveals the molecular mechanism of acute Cd stress in oysters and explores the molecular mechanism of high tolerance to Cd in oysters by using combined metabolomics and transcriptome analysis. Article in Journal/Newspaper Crassostrea gigas Pacific oyster PubMed Central (PMC) Pacific Animals 14 16 2318 |
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PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Crassostrea gigas cadmium stress energy metabolism metabolomic transcriptomic |
spellingShingle |
Crassostrea gigas cadmium stress energy metabolism metabolomic transcriptomic Dong, Luyao Sun, Yanan Chu, Muyang Xie, Yuxin Wang, Pinyi Li, Bin Li, Zan Xu, Xiaohui Feng, Yanwei Sun, Guohua Wang, Zhongping Cui, Cuiju Wang, Weijun Yang, Jianmin Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
topic_facet |
Crassostrea gigas cadmium stress energy metabolism metabolomic transcriptomic |
description |
Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their molecular response to acute Cd exposure remain unclear. In this study, the Pacific oyster Crassostrea gigas was used as a biological model, exposed to acute Cd stress for 96 h. Transcriptomic analyses of their gills were performed, and metabolomic analyses further validated these results. In our study, a total of 111 differentially expressed metabolites (DEMs) and 2108 differentially expressed genes (DEGs) were identified under acute Cd exposure. Further analyses revealed alterations in key genes and metabolic pathways associated with heavy metal stress response. Cd exposure triggered physiological and metabolic responses in oysters, including enhanced oxidative stress and disturbances in energy metabolism, and these changes revealed the biological response of oysters to acute Cd stress. Moreover, oysters could effectively enhance the tolerance and detoxification ability to acute Cd exposure through activating ABC transporters, enhancing glutathione metabolism and sulfur relay system in gill cells, and regulating energy metabolism. This study reveals the molecular mechanism of acute Cd stress in oysters and explores the molecular mechanism of high tolerance to Cd in oysters by using combined metabolomics and transcriptome analysis. |
format |
Article in Journal/Newspaper |
author |
Dong, Luyao Sun, Yanan Chu, Muyang Xie, Yuxin Wang, Pinyi Li, Bin Li, Zan Xu, Xiaohui Feng, Yanwei Sun, Guohua Wang, Zhongping Cui, Cuiju Wang, Weijun Yang, Jianmin |
author_facet |
Dong, Luyao Sun, Yanan Chu, Muyang Xie, Yuxin Wang, Pinyi Li, Bin Li, Zan Xu, Xiaohui Feng, Yanwei Sun, Guohua Wang, Zhongping Cui, Cuiju Wang, Weijun Yang, Jianmin |
author_sort |
Dong, Luyao |
title |
Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
title_short |
Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
title_full |
Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
title_fullStr |
Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
title_full_unstemmed |
Exploration of Response Mechanisms in the Gills of Pacific Oyster ( |
title_sort |
exploration of response mechanisms in the gills of pacific oyster ( |
publisher |
MDPI |
publishDate |
2024 |
url |
https://doi.org/10.3390/ani14162318 https://pubmed.ncbi.nlm.nih.gov/39199852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350665/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Animals (Basel) ISSN:2076-2615 Volume:14 Issue:16 |
op_relation |
https://doi.org/10.3390/ani14162318 https://pubmed.ncbi.nlm.nih.gov/39199852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350665/ |
op_doi |
https://doi.org/10.3390/ani14162318 |
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Animals |
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14 |
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16 |
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