The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria.
Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biologi...
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Online Access: | https://doi.org/10.3390/idr16040041 https://pubmed.ncbi.nlm.nih.gov/39051241 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270350/ |
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ftpubmed:39051241 2024-09-15T18:26:56+00:00 The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. Bourgeois, Alexandra Lemos, Juliana Aline Souza Roucheray, Stéphanie Sergerie, Audrey Richard, Dave 2024 Jun 26 https://doi.org/10.3390/idr16040041 https://pubmed.ncbi.nlm.nih.gov/39051241 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270350/ eng eng MDPI https://doi.org/10.3390/idr16040041 https://pubmed.ncbi.nlm.nih.gov/39051241 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270350/ Infect Dis Rep ISSN:2036-7430 Volume:16 Issue:4 Canadian boreal forest Labrador tea antiparasitics antiplasmodials malaria metabolites mortiamides natural compounds northern environments northern molecules Journal Article Review 2024 ftpubmed https://doi.org/10.3390/idr16040041 2024-07-28T16:03:00Z Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum. Review Nunavut Nunavik PubMed Central (PMC) Infectious Disease Reports 16 4 543 560 |
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PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Canadian boreal forest Labrador tea antiparasitics antiplasmodials malaria metabolites mortiamides natural compounds northern environments northern molecules |
spellingShingle |
Canadian boreal forest Labrador tea antiparasitics antiplasmodials malaria metabolites mortiamides natural compounds northern environments northern molecules Bourgeois, Alexandra Lemos, Juliana Aline Souza Roucheray, Stéphanie Sergerie, Audrey Richard, Dave The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
topic_facet |
Canadian boreal forest Labrador tea antiparasitics antiplasmodials malaria metabolites mortiamides natural compounds northern environments northern molecules |
description |
Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum. |
format |
Review |
author |
Bourgeois, Alexandra Lemos, Juliana Aline Souza Roucheray, Stéphanie Sergerie, Audrey Richard, Dave |
author_facet |
Bourgeois, Alexandra Lemos, Juliana Aline Souza Roucheray, Stéphanie Sergerie, Audrey Richard, Dave |
author_sort |
Bourgeois, Alexandra |
title |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
title_short |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
title_full |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
title_fullStr |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
title_full_unstemmed |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria. |
title_sort |
paradigm shift of using natural molecules extracted from northern canada to combat malaria. |
publisher |
MDPI |
publishDate |
2024 |
url |
https://doi.org/10.3390/idr16040041 https://pubmed.ncbi.nlm.nih.gov/39051241 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270350/ |
genre |
Nunavut Nunavik |
genre_facet |
Nunavut Nunavik |
op_source |
Infect Dis Rep ISSN:2036-7430 Volume:16 Issue:4 |
op_relation |
https://doi.org/10.3390/idr16040041 https://pubmed.ncbi.nlm.nih.gov/39051241 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270350/ |
op_doi |
https://doi.org/10.3390/idr16040041 |
container_title |
Infectious Disease Reports |
container_volume |
16 |
container_issue |
4 |
container_start_page |
543 |
op_container_end_page |
560 |
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1810467564621398016 |