A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy.
Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recru...
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ftpubmed:38879579 2024-09-09T20:12:05+00:00 A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. Bekkelund, Svein I Abeler, Karin Lilleng, Hallvard Løseth, Sissel 2024 Jun 15 https://doi.org/10.1038/s41598-024-64555-x https://pubmed.ncbi.nlm.nih.gov/38879579 eng eng Nature Publishing Group https://doi.org/10.1038/s41598-024-64555-x https://pubmed.ncbi.nlm.nih.gov/38879579 © 2024. The Author(s). Sci Rep ISSN:2045-2322 Volume:14 Issue:1 Creatine kinase Electromyography HyperCKemia Nerve conduction study Polyneuropathy Journal Article 2024 ftpubmed https://doi.org/10.1038/s41598-024-64555-x 2024-06-16T16:01:00Z Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recruited from the population based Tromsø study in Norway. Neuropathy impairment score (NIS), nerve conduction studies (NCS) and electromyography (EMG) in subjects with persistent hyperCKemia (n = 113; 51 men, 62 women) and controls (n = 128; 61 men, 67 women) were performed. The hyperCKemia group had higher NIS score than the controls (p = 0.050). NCS of the tibial nerve showed decreased compound motor action potential amplitude (p < 0.001), decreased motor conduction velocity (p < 0.001) and increased F-wave latency (p = 0.044). Also, reduced sensory amplitudes of the median, ulnar, and sural nerves were found. EMG showed significantly increased average motor unit potential amplitude in all examined muscles. CK correlated positively with glycated hemoglobin and non-fasting glucose in the hyperCKemia group, although not when controlled for covariates. The length dependent polyneuropathy demonstrated in the hyperCKemia group is unexplained, but CK leakage and involvement of glucose metabolism are speculated on. Article in Journal/Newspaper Tromsø PubMed Central (PMC) Norway Tromsø Scientific Reports 14 1 |
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English |
topic |
Creatine kinase Electromyography HyperCKemia Nerve conduction study Polyneuropathy |
spellingShingle |
Creatine kinase Electromyography HyperCKemia Nerve conduction study Polyneuropathy Bekkelund, Svein I Abeler, Karin Lilleng, Hallvard Løseth, Sissel A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
topic_facet |
Creatine kinase Electromyography HyperCKemia Nerve conduction study Polyneuropathy |
description |
Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recruited from the population based Tromsø study in Norway. Neuropathy impairment score (NIS), nerve conduction studies (NCS) and electromyography (EMG) in subjects with persistent hyperCKemia (n = 113; 51 men, 62 women) and controls (n = 128; 61 men, 67 women) were performed. The hyperCKemia group had higher NIS score than the controls (p = 0.050). NCS of the tibial nerve showed decreased compound motor action potential amplitude (p < 0.001), decreased motor conduction velocity (p < 0.001) and increased F-wave latency (p = 0.044). Also, reduced sensory amplitudes of the median, ulnar, and sural nerves were found. EMG showed significantly increased average motor unit potential amplitude in all examined muscles. CK correlated positively with glycated hemoglobin and non-fasting glucose in the hyperCKemia group, although not when controlled for covariates. The length dependent polyneuropathy demonstrated in the hyperCKemia group is unexplained, but CK leakage and involvement of glucose metabolism are speculated on. |
format |
Article in Journal/Newspaper |
author |
Bekkelund, Svein I Abeler, Karin Lilleng, Hallvard Løseth, Sissel |
author_facet |
Bekkelund, Svein I Abeler, Karin Lilleng, Hallvard Løseth, Sissel |
author_sort |
Bekkelund, Svein I |
title |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
title_short |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
title_full |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
title_fullStr |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
title_full_unstemmed |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
title_sort |
case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy. |
publisher |
Nature Publishing Group |
publishDate |
2024 |
url |
https://doi.org/10.1038/s41598-024-64555-x https://pubmed.ncbi.nlm.nih.gov/38879579 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Sci Rep ISSN:2045-2322 Volume:14 Issue:1 |
op_relation |
https://doi.org/10.1038/s41598-024-64555-x https://pubmed.ncbi.nlm.nih.gov/38879579 |
op_rights |
© 2024. The Author(s). |
op_doi |
https://doi.org/10.1038/s41598-024-64555-x |
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Scientific Reports |
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14 |
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1 |
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1809946668043337728 |