[Xenotransplantation of solid organs].
Transplantation of genetically modified porcine hearts and kidneys could become a solution to the persistent shortage of human organ donors. Progress has been made in genetic engineering of donor pigs, preservation techniques after organ harvesting and immunosuppression using co-stimulation blockade...
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ftpubmed:38748210 2024-09-15T17:56:38+00:00 [Xenotransplantation of solid organs]. Schmoeckel, Michael Längin, Matthias Reichart, Bruno Abicht, Jan-Michael Bender, Martin Denner, Joachim Marckmann, Georg Brenner, Paolo Wolf, Eckhard Hagl, Christian 2024 Aug https://doi.org/10.1007/s00104-024-02093-y https://pubmed.ncbi.nlm.nih.gov/38748210 ger ger Springer https://doi.org/10.1007/s00104-024-02093-y https://pubmed.ncbi.nlm.nih.gov/38748210 © 2024. The Author(s). Chirurgie (Heidelb) ISSN:2731-698X Volume:95 Issue:8 Genetic engineering Heart Kidney Organ preservation Pilot study Journal Article Review 2024 ftpubmed https://doi.org/10.1007/s00104-024-02093-y 2024-07-31T16:03:00Z Transplantation of genetically modified porcine hearts and kidneys could become a solution to the persistent shortage of human organ donors. Progress has been made in genetic engineering of donor pigs, preservation techniques after organ harvesting and immunosuppression using co-stimulation blockade with anti-CD40/CD40L monoclonal antibodies. Progress has also been made in in the development of methods that detect pathogenic porcine viruses and prevent their transmission to the recipient. As normal land breed pig organs continue to grow in the recipient to their original size, different pig breeds (such as Auckland Island pigs) are now used which reach a final size suitable for humans. Alternatively, a knock-out of the growth hormone receptor gene has been established, e.g., in the 10GM genetically modified pigs from Revivicor/United Therapeutics, USA. The first clinical pilot studies including patients suffering from terminal heart failure are expected to start in Germany in about 2 years. Review Auckland Island PubMed Central (PMC) Die Chirurgie 95 8 603 609 |
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Open Polar |
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PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
German |
topic |
Genetic engineering Heart Kidney Organ preservation Pilot study |
spellingShingle |
Genetic engineering Heart Kidney Organ preservation Pilot study Schmoeckel, Michael Längin, Matthias Reichart, Bruno Abicht, Jan-Michael Bender, Martin Denner, Joachim Marckmann, Georg Brenner, Paolo Wolf, Eckhard Hagl, Christian [Xenotransplantation of solid organs]. |
topic_facet |
Genetic engineering Heart Kidney Organ preservation Pilot study |
description |
Transplantation of genetically modified porcine hearts and kidneys could become a solution to the persistent shortage of human organ donors. Progress has been made in genetic engineering of donor pigs, preservation techniques after organ harvesting and immunosuppression using co-stimulation blockade with anti-CD40/CD40L monoclonal antibodies. Progress has also been made in in the development of methods that detect pathogenic porcine viruses and prevent their transmission to the recipient. As normal land breed pig organs continue to grow in the recipient to their original size, different pig breeds (such as Auckland Island pigs) are now used which reach a final size suitable for humans. Alternatively, a knock-out of the growth hormone receptor gene has been established, e.g., in the 10GM genetically modified pigs from Revivicor/United Therapeutics, USA. The first clinical pilot studies including patients suffering from terminal heart failure are expected to start in Germany in about 2 years. |
format |
Review |
author |
Schmoeckel, Michael Längin, Matthias Reichart, Bruno Abicht, Jan-Michael Bender, Martin Denner, Joachim Marckmann, Georg Brenner, Paolo Wolf, Eckhard Hagl, Christian |
author_facet |
Schmoeckel, Michael Längin, Matthias Reichart, Bruno Abicht, Jan-Michael Bender, Martin Denner, Joachim Marckmann, Georg Brenner, Paolo Wolf, Eckhard Hagl, Christian |
author_sort |
Schmoeckel, Michael |
title |
[Xenotransplantation of solid organs]. |
title_short |
[Xenotransplantation of solid organs]. |
title_full |
[Xenotransplantation of solid organs]. |
title_fullStr |
[Xenotransplantation of solid organs]. |
title_full_unstemmed |
[Xenotransplantation of solid organs]. |
title_sort |
[xenotransplantation of solid organs]. |
publisher |
Springer |
publishDate |
2024 |
url |
https://doi.org/10.1007/s00104-024-02093-y https://pubmed.ncbi.nlm.nih.gov/38748210 |
genre |
Auckland Island |
genre_facet |
Auckland Island |
op_source |
Chirurgie (Heidelb) ISSN:2731-698X Volume:95 Issue:8 |
op_relation |
https://doi.org/10.1007/s00104-024-02093-y https://pubmed.ncbi.nlm.nih.gov/38748210 |
op_rights |
© 2024. The Author(s). |
op_doi |
https://doi.org/10.1007/s00104-024-02093-y |
container_title |
Die Chirurgie |
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95 |
container_issue |
8 |
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609 |
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1810432825201000448 |