[Xenotransplantation of solid organs].

Transplantation of genetically modified porcine hearts and kidneys could become a solution to the persistent shortage of human organ donors. Progress has been made in genetic engineering of donor pigs, preservation techniques after organ harvesting and immunosuppression using co-stimulation blockade...

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Bibliographic Details
Published in:Die Chirurgie
Main Authors: Schmoeckel, Michael, Längin, Matthias, Reichart, Bruno, Abicht, Jan-Michael, Bender, Martin, Denner, Joachim, Marckmann, Georg, Brenner, Paolo, Wolf, Eckhard, Hagl, Christian
Format: Review
Language:German
Published: Springer 2024
Subjects:
Genetic engineering
Heart
Kidney
Organ preservation
Pilot study
Auckland Island
Online Access:https://doi.org/10.1007/s00104-024-02093-y
https://pubmed.ncbi.nlm.nih.gov/38748210
Description
Summary:Transplantation of genetically modified porcine hearts and kidneys could become a solution to the persistent shortage of human organ donors. Progress has been made in genetic engineering of donor pigs, preservation techniques after organ harvesting and immunosuppression using co-stimulation blockade with anti-CD40/CD40L monoclonal antibodies. Progress has also been made in in the development of methods that detect pathogenic porcine viruses and prevent their transmission to the recipient. As normal land breed pig organs continue to grow in the recipient to their original size, different pig breeds (such as Auckland Island pigs) are now used which reach a final size suitable for humans. Alternatively, a knock-out of the growth hormone receptor gene has been established, e.g., in the 10GM genetically modified pigs from Revivicor/United Therapeutics, USA. The first clinical pilot studies including patients suffering from terminal heart failure are expected to start in Germany in about 2 years.

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