Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon.
The immunomodulatory effects of omega-3 and omega-6 fatty acids are a crucial subject of investigation for sustainable fish aquaculture, as fish oil is increasingly replaced by terrestrial vegetable oils in aquafeeds. Unlike previous research focusing on fish oil replacement with vegetable alternati...
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ftpubmed:38740811 2024-06-09T07:44:47+00:00 Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. Caballero-Solares, Albert Eslamloo, Khalil Hall, Jennifer R Katan, Tomer Emam, Mohamed Xue, Xi Taylor, Richard G Balder, Rachel Parrish, Christopher C Rise, Matthew L 2024-05-13 https://doi.org/10.1038/s41598-024-61144-w https://pubmed.ncbi.nlm.nih.gov/38740811 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091188/ eng eng Nature Publishing Group https://doi.org/10.1038/s41598-024-61144-w https://pubmed.ncbi.nlm.nih.gov/38740811 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091188/ © 2024. The Author(s). Sci Rep ISSN:2045-2322 Volume:14 Issue:1 Journal Article 2024 ftpubmed https://doi.org/10.1038/s41598-024-61144-w 2024-05-16T16:03:00Z The immunomodulatory effects of omega-3 and omega-6 fatty acids are a crucial subject of investigation for sustainable fish aquaculture, as fish oil is increasingly replaced by terrestrial vegetable oils in aquafeeds. Unlike previous research focusing on fish oil replacement with vegetable alternatives, our study explored how the omega-6 to omega-3 polyunsaturated fatty acid (PUFA) ratio in low-fish oil aquafeeds influences Atlantic salmon's antiviral and antibacterial immune responses. Atlantic salmon were fed aquafeeds rich in soy oil (high in omega-6) or linseed oil (high in omega-3) for 12 weeks and then challenged with bacterial (formalin-killed Aeromonas salmonicida) or viral-like (polyriboinosinic polyribocytidylic acid) antigens. The head kidneys of salmon fed high dietary omega-3 levels exhibited a more anti-inflammatory fatty acid profile and a restrained induction of pro-inflammatory and neutrophil-related genes during the immune challenges. The high-omega-3 diet also promoted a higher expression of genes associated with the interferon-mediated signaling pathway, potentially enhancing antiviral immunity. This research highlights the capacity of vegetable oils with different omega-6 to omega-3 PUFA ratios to modulate specific components of fish immune responses, offering insights for future research on the intricate lipid nutrition-immunity interplay and the development of novel sustainable low-fish oil clinical aquaculture feeds. Article in Journal/Newspaper Atlantic salmon PubMed Central (PMC) Scientific Reports 14 1 |
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The immunomodulatory effects of omega-3 and omega-6 fatty acids are a crucial subject of investigation for sustainable fish aquaculture, as fish oil is increasingly replaced by terrestrial vegetable oils in aquafeeds. Unlike previous research focusing on fish oil replacement with vegetable alternatives, our study explored how the omega-6 to omega-3 polyunsaturated fatty acid (PUFA) ratio in low-fish oil aquafeeds influences Atlantic salmon's antiviral and antibacterial immune responses. Atlantic salmon were fed aquafeeds rich in soy oil (high in omega-6) or linseed oil (high in omega-3) for 12 weeks and then challenged with bacterial (formalin-killed Aeromonas salmonicida) or viral-like (polyriboinosinic polyribocytidylic acid) antigens. The head kidneys of salmon fed high dietary omega-3 levels exhibited a more anti-inflammatory fatty acid profile and a restrained induction of pro-inflammatory and neutrophil-related genes during the immune challenges. The high-omega-3 diet also promoted a higher expression of genes associated with the interferon-mediated signaling pathway, potentially enhancing antiviral immunity. This research highlights the capacity of vegetable oils with different omega-6 to omega-3 PUFA ratios to modulate specific components of fish immune responses, offering insights for future research on the intricate lipid nutrition-immunity interplay and the development of novel sustainable low-fish oil clinical aquaculture feeds. |
format |
Article in Journal/Newspaper |
author |
Caballero-Solares, Albert Eslamloo, Khalil Hall, Jennifer R Katan, Tomer Emam, Mohamed Xue, Xi Taylor, Richard G Balder, Rachel Parrish, Christopher C Rise, Matthew L |
spellingShingle |
Caballero-Solares, Albert Eslamloo, Khalil Hall, Jennifer R Katan, Tomer Emam, Mohamed Xue, Xi Taylor, Richard G Balder, Rachel Parrish, Christopher C Rise, Matthew L Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
author_facet |
Caballero-Solares, Albert Eslamloo, Khalil Hall, Jennifer R Katan, Tomer Emam, Mohamed Xue, Xi Taylor, Richard G Balder, Rachel Parrish, Christopher C Rise, Matthew L |
author_sort |
Caballero-Solares, Albert |
title |
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
title_short |
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
title_full |
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
title_fullStr |
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
title_full_unstemmed |
Vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of Atlantic salmon. |
title_sort |
vegetable omega-3 and omega-6 fatty acids differentially modulate the antiviral and antibacterial immune responses of atlantic salmon. |
publisher |
Nature Publishing Group |
publishDate |
2024 |
url |
https://doi.org/10.1038/s41598-024-61144-w https://pubmed.ncbi.nlm.nih.gov/38740811 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091188/ |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Sci Rep ISSN:2045-2322 Volume:14 Issue:1 |
op_relation |
https://doi.org/10.1038/s41598-024-61144-w https://pubmed.ncbi.nlm.nih.gov/38740811 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091188/ |
op_rights |
© 2024. The Author(s). |
op_doi |
https://doi.org/10.1038/s41598-024-61144-w |
container_title |
Scientific Reports |
container_volume |
14 |
container_issue |
1 |
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1801373597977018368 |