Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.
The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this quest...
Published in: | Communications Biology |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2024
|
Subjects: | |
Online Access: | https://doi.org/10.1038/s42003-024-06198-2 https://pubmed.ncbi.nlm.nih.gov/38714798 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076565/ |
id |
ftpubmed:38714798 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:38714798 2024-06-09T07:47:10+00:00 Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan 2024 May 07 https://doi.org/10.1038/s42003-024-06198-2 https://pubmed.ncbi.nlm.nih.gov/38714798 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076565/ eng eng Nature Publishing Group https://doi.org/10.1038/s42003-024-06198-2 https://pubmed.ncbi.nlm.nih.gov/38714798 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076565/ © 2024. The Author(s). Commun Biol ISSN:2399-3642 Volume:7 Issue:1 Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural 2024 ftpubmed https://doi.org/10.1038/s42003-024-06198-2 2024-05-10T16:03:00Z The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin). Article in Journal/Newspaper Iceland PubMed Central (PMC) Communications Biology 7 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
description |
The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin). |
format |
Article in Journal/Newspaper |
author |
Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan |
spellingShingle |
Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
author_facet |
Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan |
author_sort |
Di, Yazheng |
title |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_short |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_full |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_fullStr |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_full_unstemmed |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_sort |
genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
publisher |
Nature Publishing Group |
publishDate |
2024 |
url |
https://doi.org/10.1038/s42003-024-06198-2 https://pubmed.ncbi.nlm.nih.gov/38714798 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076565/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Commun Biol ISSN:2399-3642 Volume:7 Issue:1 |
op_relation |
https://doi.org/10.1038/s42003-024-06198-2 https://pubmed.ncbi.nlm.nih.gov/38714798 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076565/ |
op_rights |
© 2024. The Author(s). |
op_doi |
https://doi.org/10.1038/s42003-024-06198-2 |
container_title |
Communications Biology |
container_volume |
7 |
container_issue |
1 |
_version_ |
1801378104398053376 |