In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus.
Polyphenols (PP) found in brown algae are known for their wide range of biological activities including noteworthy antitumor properties. This article presents a method for obtaining an active polyphenolic extract from the Arctic alga Fucus vesiculosus with 98% purity and radical scavenging activity...
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ftpubmed:38613704 2024-05-12T07:59:24+00:00 In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. Bogolitsyn, Konstantin Dobrodeeva, Liliya Samodova, Anna Parshina, Anastasia 2024 Apr 13 https://doi.org/10.1007/s11130-024-01174-x https://pubmed.ncbi.nlm.nih.gov/38613704 eng eng Springer https://doi.org/10.1007/s11130-024-01174-x https://pubmed.ncbi.nlm.nih.gov/38613704 © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. Plant Foods Hum Nutr ISSN:1573-9104 Brown Algae Cytogram Immune Response Immunostimulant Activity Polyphenol Journal Article 2024 ftpubmed https://doi.org/10.1007/s11130-024-01174-x 2024-04-14T16:01:00Z Polyphenols (PP) found in brown algae are known for their wide range of biological activities including noteworthy antitumor properties. This article presents a method for obtaining an active polyphenolic extract from the Arctic alga Fucus vesiculosus with 98% purity and radical scavenging activity equivalent to 862 mg of ascorbic acid per gram of extract. Immunostimulant effects of polyphenols were assessed in vitro using venous blood from two groups of people: healthy people (HP) and people with chronic undifferentiated lymphocytic leukemia (LP). Polyphenols activated the surface properties of immunocompetent cells. Specifically, polyphenols dose-dependently increased the percentage of cells' spreading and adhesion by 2-3 times. Additionally, polyphenols increased the number of activated lymphocytes in the LP blood to levels characteristic of HP. Given their natural origin, high activity, non-toxicity, and straightforward production process, these studied polyphenols exhibit immense potential for use as new pharmaceuticals or as active components with immunostimulatory effects. Article in Journal/Newspaper Arctic PubMed Central (PMC) Arctic Plant Foods for Human Nutrition |
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Open Polar |
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PubMed Central (PMC) |
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ftpubmed |
language |
English |
topic |
Brown Algae Cytogram Immune Response Immunostimulant Activity Polyphenol |
spellingShingle |
Brown Algae Cytogram Immune Response Immunostimulant Activity Polyphenol Bogolitsyn, Konstantin Dobrodeeva, Liliya Samodova, Anna Parshina, Anastasia In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
topic_facet |
Brown Algae Cytogram Immune Response Immunostimulant Activity Polyphenol |
description |
Polyphenols (PP) found in brown algae are known for their wide range of biological activities including noteworthy antitumor properties. This article presents a method for obtaining an active polyphenolic extract from the Arctic alga Fucus vesiculosus with 98% purity and radical scavenging activity equivalent to 862 mg of ascorbic acid per gram of extract. Immunostimulant effects of polyphenols were assessed in vitro using venous blood from two groups of people: healthy people (HP) and people with chronic undifferentiated lymphocytic leukemia (LP). Polyphenols activated the surface properties of immunocompetent cells. Specifically, polyphenols dose-dependently increased the percentage of cells' spreading and adhesion by 2-3 times. Additionally, polyphenols increased the number of activated lymphocytes in the LP blood to levels characteristic of HP. Given their natural origin, high activity, non-toxicity, and straightforward production process, these studied polyphenols exhibit immense potential for use as new pharmaceuticals or as active components with immunostimulatory effects. |
format |
Article in Journal/Newspaper |
author |
Bogolitsyn, Konstantin Dobrodeeva, Liliya Samodova, Anna Parshina, Anastasia |
author_facet |
Bogolitsyn, Konstantin Dobrodeeva, Liliya Samodova, Anna Parshina, Anastasia |
author_sort |
Bogolitsyn, Konstantin |
title |
In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
title_short |
In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
title_full |
In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
title_fullStr |
In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
title_full_unstemmed |
In vitro Immunostimulant Activity of the Polyphenolic Extract from the Arctic Brown Algae Fucus vesiculosus. |
title_sort |
in vitro immunostimulant activity of the polyphenolic extract from the arctic brown algae fucus vesiculosus. |
publisher |
Springer |
publishDate |
2024 |
url |
https://doi.org/10.1007/s11130-024-01174-x https://pubmed.ncbi.nlm.nih.gov/38613704 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Plant Foods Hum Nutr ISSN:1573-9104 |
op_relation |
https://doi.org/10.1007/s11130-024-01174-x https://pubmed.ncbi.nlm.nih.gov/38613704 |
op_rights |
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
op_doi |
https://doi.org/10.1007/s11130-024-01174-x |
container_title |
Plant Foods for Human Nutrition |
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1798840680671346688 |