[Cu(NN
Piscirickettsia salmonis is the pathogen that most affects the salmon industry in Chile. Large quantities of antibiotics have been used to control it. In search of alternatives, we have developed [Cu(NN1)2]ClO4 where NN1 = 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one. The antibacterial capacit...
Published in: | International Journal of Molecular Sciences |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI
2024
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijms25073700 https://pubmed.ncbi.nlm.nih.gov/38612511 |
id |
ftpubmed:38612511 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:38612511 2024-05-12T08:01:22+00:00 [Cu(NN Parra, Mick Aldabaldetrecu, Maialen Arce, Pablo Soto-Aguilera, Sarita Vargas, Rodrigo Guerrero, Juan Tello, Mario Modak, Brenda 2024 Mar 26 https://doi.org/10.3390/ijms25073700 https://pubmed.ncbi.nlm.nih.gov/38612511 eng eng MDPI https://doi.org/10.3390/ijms25073700 https://pubmed.ncbi.nlm.nih.gov/38612511 Int J Mol Sci ISSN:1422-0067 Volume:25 Issue:7 Atlantic salmon Piscirickettsia salmonis Piscirickettsiosis Salmo salar antimicrobial copper (I) complex immune system intestinal microbiota Journal Article 2024 ftpubmed https://doi.org/10.3390/ijms25073700 2024-04-13T16:02:00Z Piscirickettsia salmonis is the pathogen that most affects the salmon industry in Chile. Large quantities of antibiotics have been used to control it. In search of alternatives, we have developed [Cu(NN1)2]ClO4 where NN1 = 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one. The antibacterial capacity of [Cu(NN1)2]ClO4 was determined. Subsequently, the effect of the administration of [Cu(NN1)2]ClO4 on the growth of S. salar, modulation of the immune system and the intestinal microbiota was studied. Finally, the ability to protect against a challenge with P. salmonis was evaluated. The results obtained showed that the compound has an MIC between 15 and 33.9 μg/mL in four isolates. On the other hand, the compound did not affect the growth of the fish; however, an increase in the transcript levels of IFN-γ, IL-12, IL-1β, CD4, lysozyme and perforin was observed in fish treated with 40 μg/g of fish. Furthermore, modulation of the intestinal microbiota was observed, increasing the genera of beneficial bacteria such as Lactobacillus and Bacillus as well as potential pathogens such as Vibrio and Piscirickettsia. Finally, the treatment increased survival in fish challenged with P. salmonis by more than 60%. These results demonstrate that the compound is capable of protecting fish against P. salmonis, probably by modulating the immune system and the composition of the intestinal microbiota. Article in Journal/Newspaper Atlantic salmon Salmo salar PubMed Central (PMC) International Journal of Molecular Sciences 25 7 3700 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Atlantic salmon Piscirickettsia salmonis Piscirickettsiosis Salmo salar antimicrobial copper (I) complex immune system intestinal microbiota |
spellingShingle |
Atlantic salmon Piscirickettsia salmonis Piscirickettsiosis Salmo salar antimicrobial copper (I) complex immune system intestinal microbiota Parra, Mick Aldabaldetrecu, Maialen Arce, Pablo Soto-Aguilera, Sarita Vargas, Rodrigo Guerrero, Juan Tello, Mario Modak, Brenda [Cu(NN |
topic_facet |
Atlantic salmon Piscirickettsia salmonis Piscirickettsiosis Salmo salar antimicrobial copper (I) complex immune system intestinal microbiota |
description |
Piscirickettsia salmonis is the pathogen that most affects the salmon industry in Chile. Large quantities of antibiotics have been used to control it. In search of alternatives, we have developed [Cu(NN1)2]ClO4 where NN1 = 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one. The antibacterial capacity of [Cu(NN1)2]ClO4 was determined. Subsequently, the effect of the administration of [Cu(NN1)2]ClO4 on the growth of S. salar, modulation of the immune system and the intestinal microbiota was studied. Finally, the ability to protect against a challenge with P. salmonis was evaluated. The results obtained showed that the compound has an MIC between 15 and 33.9 μg/mL in four isolates. On the other hand, the compound did not affect the growth of the fish; however, an increase in the transcript levels of IFN-γ, IL-12, IL-1β, CD4, lysozyme and perforin was observed in fish treated with 40 μg/g of fish. Furthermore, modulation of the intestinal microbiota was observed, increasing the genera of beneficial bacteria such as Lactobacillus and Bacillus as well as potential pathogens such as Vibrio and Piscirickettsia. Finally, the treatment increased survival in fish challenged with P. salmonis by more than 60%. These results demonstrate that the compound is capable of protecting fish against P. salmonis, probably by modulating the immune system and the composition of the intestinal microbiota. |
format |
Article in Journal/Newspaper |
author |
Parra, Mick Aldabaldetrecu, Maialen Arce, Pablo Soto-Aguilera, Sarita Vargas, Rodrigo Guerrero, Juan Tello, Mario Modak, Brenda |
author_facet |
Parra, Mick Aldabaldetrecu, Maialen Arce, Pablo Soto-Aguilera, Sarita Vargas, Rodrigo Guerrero, Juan Tello, Mario Modak, Brenda |
author_sort |
Parra, Mick |
title |
[Cu(NN |
title_short |
[Cu(NN |
title_full |
[Cu(NN |
title_fullStr |
[Cu(NN |
title_full_unstemmed |
[Cu(NN |
title_sort |
[cu(nn |
publisher |
MDPI |
publishDate |
2024 |
url |
https://doi.org/10.3390/ijms25073700 https://pubmed.ncbi.nlm.nih.gov/38612511 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Int J Mol Sci ISSN:1422-0067 Volume:25 Issue:7 |
op_relation |
https://doi.org/10.3390/ijms25073700 https://pubmed.ncbi.nlm.nih.gov/38612511 |
op_doi |
https://doi.org/10.3390/ijms25073700 |
container_title |
International Journal of Molecular Sciences |
container_volume |
25 |
container_issue |
7 |
container_start_page |
3700 |
_version_ |
1798843490966175744 |