Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage.
Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with ec...
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Online Access: | https://doi.org/10.1002/fsn3.2847 https://pubmed.ncbi.nlm.nih.gov/35844927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ |
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ftpubmed:35844927 2024-09-30T14:33:58+00:00 Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. Siregar, Adrian S Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Park, Si-Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon 2022 Jul https://doi.org/10.1002/fsn3.2847 https://pubmed.ncbi.nlm.nih.gov/35844927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ eng eng PubMed Central https://doi.org/10.1002/fsn3.2847 https://pubmed.ncbi.nlm.nih.gov/35844927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. Food Sci Nutr ISSN:2048-7177 Volume:10 Issue:7 alcohols functional foods inflammation liver injury oxidative stress oyster broth concentrate Journal Article 2022 ftpubmed https://doi.org/10.1002/fsn3.2847 2024-08-31T16:02:00Z Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by-product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single-EtOH-binge-drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca2+ concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF-κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH-induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects. Article in Journal/Newspaper Crassostrea gigas PubMed Central (PMC) Food Science & Nutrition 10 7 2390 2399 |
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language |
English |
topic |
alcohols functional foods inflammation liver injury oxidative stress oyster broth concentrate |
spellingShingle |
alcohols functional foods inflammation liver injury oxidative stress oyster broth concentrate Siregar, Adrian S Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Park, Si-Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
topic_facet |
alcohols functional foods inflammation liver injury oxidative stress oyster broth concentrate |
description |
Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by-product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single-EtOH-binge-drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca2+ concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF-κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH-induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects. |
format |
Article in Journal/Newspaper |
author |
Siregar, Adrian S Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Park, Si-Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon |
author_facet |
Siregar, Adrian S Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Park, Si-Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon |
author_sort |
Siregar, Adrian S |
title |
Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
title_short |
Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
title_full |
Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
title_fullStr |
Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
title_full_unstemmed |
Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
title_sort |
oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage. |
publisher |
PubMed Central |
publishDate |
2022 |
url |
https://doi.org/10.1002/fsn3.2847 https://pubmed.ncbi.nlm.nih.gov/35844927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Food Sci Nutr ISSN:2048-7177 Volume:10 Issue:7 |
op_relation |
https://doi.org/10.1002/fsn3.2847 https://pubmed.ncbi.nlm.nih.gov/35844927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ |
op_rights |
© 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. |
op_doi |
https://doi.org/10.1002/fsn3.2847 |
container_title |
Food Science & Nutrition |
container_volume |
10 |
container_issue |
7 |
container_start_page |
2390 |
op_container_end_page |
2399 |
_version_ |
1811637717182709760 |