Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived
Extracts from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019 showed potent antibacterial bioactivities. We report herein the isolation of chrysonin (1), a new compound containing a pair of enantiomers 6S- and 6R-chrysonin (1a and 1b) featuring an unprecedented eight-membered heterocycle f...
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Online Access: | https://doi.org/10.1039/d0ra03529g https://pubmed.ncbi.nlm.nih.gov/35517746 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054296/ |
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ftpubmed:35517746 2024-09-15T17:48:42+00:00 Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Khan, Imran Zhang, Haibo Liu, Wei Zhang, Liping Peng, Fang Chen, Yuchan Zhang, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, Changsheng 2020 May 27 https://doi.org/10.1039/d0ra03529g https://pubmed.ncbi.nlm.nih.gov/35517746 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054296/ eng eng PubMed Central https://doi.org/10.1039/d0ra03529g https://pubmed.ncbi.nlm.nih.gov/35517746 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054296/ This journal is © The Royal Society of Chemistry. RSC Adv ISSN:2046-2069 Volume:10 Issue:35 Journal Article 2020 ftpubmed https://doi.org/10.1039/d0ra03529g 2024-08-27T16:03:00Z Extracts from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019 showed potent antibacterial bioactivities. We report herein the isolation of chrysonin (1), a new compound containing a pair of enantiomers 6S- and 6R-chrysonin (1a and 1b) featuring an unprecedented eight-membered heterocycle fused with a benzene ring. Compound 2, a mixture consisting of a new zwitterionic compound chrysomamide (2a) and N-[2-trans-(4-hydroxyphenyl) ethenyl] formamide (2b) in a ratio around 1 : 2.8, was isolated together with seven known compounds 3-9. Chemical structures of all compounds were determined by comprehensive spectroscopic analyses. The isolated compounds were evaluated for antimicrobial, cytotoxic and alpha-glucosidase inhibition activities. Chrysonin (1) showed moderate alpha-glucosidase inhibitory activity. The dominant product xanthocillin X (4) displayed potent inhibition activities against Gram-negative pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa with MIC values at 0.125 μg mL-1. Xanthocillins X (4) and Y1 (5) also showed significant cytotoxicities against four cancer cell lines with IC50 values ranging from 0.26 to 5.04 μM. This study highlights that microorganisms from polar regions are emerging as a new resource for the discovery of natural products combating human pathogens. Article in Journal/Newspaper Antarc* Antarctic PubMed Central (PMC) RSC Advances 10 35 20738 20744 |
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English |
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Extracts from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019 showed potent antibacterial bioactivities. We report herein the isolation of chrysonin (1), a new compound containing a pair of enantiomers 6S- and 6R-chrysonin (1a and 1b) featuring an unprecedented eight-membered heterocycle fused with a benzene ring. Compound 2, a mixture consisting of a new zwitterionic compound chrysomamide (2a) and N-[2-trans-(4-hydroxyphenyl) ethenyl] formamide (2b) in a ratio around 1 : 2.8, was isolated together with seven known compounds 3-9. Chemical structures of all compounds were determined by comprehensive spectroscopic analyses. The isolated compounds were evaluated for antimicrobial, cytotoxic and alpha-glucosidase inhibition activities. Chrysonin (1) showed moderate alpha-glucosidase inhibitory activity. The dominant product xanthocillin X (4) displayed potent inhibition activities against Gram-negative pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa with MIC values at 0.125 μg mL-1. Xanthocillins X (4) and Y1 (5) also showed significant cytotoxicities against four cancer cell lines with IC50 values ranging from 0.26 to 5.04 μM. This study highlights that microorganisms from polar regions are emerging as a new resource for the discovery of natural products combating human pathogens. |
format |
Article in Journal/Newspaper |
author |
Khan, Imran Zhang, Haibo Liu, Wei Zhang, Liping Peng, Fang Chen, Yuchan Zhang, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, Changsheng |
spellingShingle |
Khan, Imran Zhang, Haibo Liu, Wei Zhang, Liping Peng, Fang Chen, Yuchan Zhang, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, Changsheng Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
author_facet |
Khan, Imran Zhang, Haibo Liu, Wei Zhang, Liping Peng, Fang Chen, Yuchan Zhang, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, Changsheng |
author_sort |
Khan, Imran |
title |
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
title_short |
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
title_full |
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
title_fullStr |
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
title_full_unstemmed |
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived |
title_sort |
identification and bioactivity evaluation of secondary metabolites from antarctic-derived |
publisher |
PubMed Central |
publishDate |
2020 |
url |
https://doi.org/10.1039/d0ra03529g https://pubmed.ncbi.nlm.nih.gov/35517746 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054296/ |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
RSC Adv ISSN:2046-2069 Volume:10 Issue:35 |
op_relation |
https://doi.org/10.1039/d0ra03529g https://pubmed.ncbi.nlm.nih.gov/35517746 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054296/ |
op_rights |
This journal is © The Royal Society of Chemistry. |
op_doi |
https://doi.org/10.1039/d0ra03529g |
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35 |
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20744 |
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1810290204434497536 |