Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study.

Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and p...

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Bibliographic Details
Published in:BMC Medicine
Main Authors: Röhnisch, Hanna E, Kyrø, Cecilie, Olsen, Anja, Thysell, Elin, Hallmans, Göran, Moazzami, Ali A
Format: Article in Journal/Newspaper
Language:English
Published: BioMed Central 2020
Subjects:
Mass spectrometry
Metabolomics
Nested case-control study
Nuclear magnetic resonance spectroscopy
Prostate cancer
Risk biomarkers
Northern Sweden
Online Access:https://doi.org/10.1186/s12916-020-01655-1
https://pubmed.ncbi.nlm.nih.gov/32698845
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376662/
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Summary:Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age.

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