A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure.
In this randomized, double-blind, placebo-controlled, multicentre, parallel, 8-week study, the efficacy of a daily dose of 1200 mg of protein hydrolysate from Coldwater Shrimp (Pandalus borealis) on ambulatory and office blood pressure was investigated in 144 free-living adults with mild to moderate...
Published in: | International Journal of Hypertension |
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Online Access: | https://doi.org/10.1155/2019/2345042 https://pubmed.ncbi.nlm.nih.gov/31467699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699271/ |
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ftpubmed:31467699 2024-09-15T18:29:08+00:00 A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. Musa-Veloso, Kathy Paulionis, Lina Pelipyagina, Tetyana Evans, Mal 2019 https://doi.org/10.1155/2019/2345042 https://pubmed.ncbi.nlm.nih.gov/31467699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699271/ eng eng PubMed Central https://doi.org/10.1155/2019/2345042 https://pubmed.ncbi.nlm.nih.gov/31467699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699271/ Int J Hypertens ISSN:2090-0384 Volume:2019 Journal Article 2019 ftpubmed https://doi.org/10.1155/2019/2345042 2024-07-19T16:02:00Z In this randomized, double-blind, placebo-controlled, multicentre, parallel, 8-week study, the efficacy of a daily dose of 1200 mg of protein hydrolysate from Coldwater Shrimp (Pandalus borealis) on ambulatory and office blood pressure was investigated in 144 free-living adults with mild to moderate hypertension. The primary outcomes of the study were daytime ambulatory systolic blood pressure and office blood pressure. During the 8-week intervention period and in the intention-to-treat analysis (n=144), there were significant reductions in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group in daytime ambulatory systolic blood pressure at 4 weeks (p=0.014) and at 8 weeks (p=0.002), and in office systolic blood pressure at 2 weeks (p=0.031) and 4 weeks (p=0.010), with a trend toward significance at 8 weeks (p=0.087). By 8 weeks, significant and favourable improvements in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group were also observed for several secondary outcomes, including 24-hour ambulatory systolic and diastolic blood pressure, daytime ambulatory diastolic blood pressure, and daytime and 24-hour ambulatory mean arterial pressure. Also by Week 8, there was a statistically significant difference between groups in the distribution of subjects across National Institutes of Health-defined blood pressure categories (i.e., Normotensive, Prehypertensive, Stage 1 hypertension, and Stage 2 hypertension), with a more favourable distribution in the shrimp-derived protein hydrolysate group than in the placebo group (p=0.006). Based on exploratory analyses conducted only in participants in the shrimp-derived protein hydrolysate group, angiotensin II levels were significantly reduced relative to baseline. This study is registered at ClinicalTrials.gov NCT01974570. Article in Journal/Newspaper Pandalus borealis PubMed Central (PMC) International Journal of Hypertension 2019 1 13 |
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PubMed Central (PMC) |
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language |
English |
description |
In this randomized, double-blind, placebo-controlled, multicentre, parallel, 8-week study, the efficacy of a daily dose of 1200 mg of protein hydrolysate from Coldwater Shrimp (Pandalus borealis) on ambulatory and office blood pressure was investigated in 144 free-living adults with mild to moderate hypertension. The primary outcomes of the study were daytime ambulatory systolic blood pressure and office blood pressure. During the 8-week intervention period and in the intention-to-treat analysis (n=144), there were significant reductions in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group in daytime ambulatory systolic blood pressure at 4 weeks (p=0.014) and at 8 weeks (p=0.002), and in office systolic blood pressure at 2 weeks (p=0.031) and 4 weeks (p=0.010), with a trend toward significance at 8 weeks (p=0.087). By 8 weeks, significant and favourable improvements in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group were also observed for several secondary outcomes, including 24-hour ambulatory systolic and diastolic blood pressure, daytime ambulatory diastolic blood pressure, and daytime and 24-hour ambulatory mean arterial pressure. Also by Week 8, there was a statistically significant difference between groups in the distribution of subjects across National Institutes of Health-defined blood pressure categories (i.e., Normotensive, Prehypertensive, Stage 1 hypertension, and Stage 2 hypertension), with a more favourable distribution in the shrimp-derived protein hydrolysate group than in the placebo group (p=0.006). Based on exploratory analyses conducted only in participants in the shrimp-derived protein hydrolysate group, angiotensin II levels were significantly reduced relative to baseline. This study is registered at ClinicalTrials.gov NCT01974570. |
format |
Article in Journal/Newspaper |
author |
Musa-Veloso, Kathy Paulionis, Lina Pelipyagina, Tetyana Evans, Mal |
spellingShingle |
Musa-Veloso, Kathy Paulionis, Lina Pelipyagina, Tetyana Evans, Mal A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
author_facet |
Musa-Veloso, Kathy Paulionis, Lina Pelipyagina, Tetyana Evans, Mal |
author_sort |
Musa-Veloso, Kathy |
title |
A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
title_short |
A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
title_full |
A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
title_fullStr |
A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
title_full_unstemmed |
A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure. |
title_sort |
randomized, double-blind, placebo-controlled, multicentre trial of the effects of a shrimp protein hydrolysate on blood pressure. |
publisher |
PubMed Central |
publishDate |
2019 |
url |
https://doi.org/10.1155/2019/2345042 https://pubmed.ncbi.nlm.nih.gov/31467699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699271/ |
genre |
Pandalus borealis |
genre_facet |
Pandalus borealis |
op_source |
Int J Hypertens ISSN:2090-0384 Volume:2019 |
op_relation |
https://doi.org/10.1155/2019/2345042 https://pubmed.ncbi.nlm.nih.gov/31467699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699271/ |
op_doi |
https://doi.org/10.1155/2019/2345042 |
container_title |
International Journal of Hypertension |
container_volume |
2019 |
container_start_page |
1 |
op_container_end_page |
13 |
_version_ |
1810470546629984256 |