The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.

• Published in: Translational Psychiatry
• Main Authors: Szatkiewicz, Jin, Crowley, James J, Adolfsson, Annelie Nordin, Åberg, Karolina A, Alaerts, Maaike, Genovese, Giulio, McCarroll, Steven, Del-Favero, Jurgen, Adolfsson, Rolf, Sullivan, Patrick F
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2019
• Subjects: Northern Sweden
• Online Access: https://doi.org/10.1038/s41398-019-0414-9; https://pubmed.ncbi.nlm.nih.gov/30718465; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.