Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum.
Exposure of polar bears (Ursus maritimus) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range...
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Online Access: | https://doi.org/10.1002/anie.201809906 https://pubmed.ncbi.nlm.nih.gov/30376612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394828/ |
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ftpubmed:30376612 2024-09-15T17:58:42+00:00 Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. Liu, Yanna Richardson, Evan S Derocher, Andrew E Lunn, Nicholas J Lehmler, Hans-Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W 2018-12-10 https://doi.org/10.1002/anie.201809906 https://pubmed.ncbi.nlm.nih.gov/30376612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394828/ eng eng Wiley https://doi.org/10.1002/anie.201809906 https://pubmed.ncbi.nlm.nih.gov/30376612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394828/ © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Angew Chem Int Ed Engl ISSN:1521-3773 Volume:57 Issue:50 environmental chemistry halogenated contaminants mass spectrometry nontarget discovery polar bear Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2018 ftpubmed https://doi.org/10.1002/anie.201809906 2024-07-14T16:03:00Z Exposure of polar bears (Ursus maritimus) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with "fragmentation flagging" was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid-1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and these halogenated contaminants pose uncertain risks to this threatened species. Article in Journal/Newspaper Beaufort Sea Hudson Bay Ursus maritimus PubMed Central (PMC) Angewandte Chemie International Edition 57 50 16401 16406 |
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PubMed Central (PMC) |
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ftpubmed |
language |
English |
topic |
environmental chemistry halogenated contaminants mass spectrometry nontarget discovery polar bear |
spellingShingle |
environmental chemistry halogenated contaminants mass spectrometry nontarget discovery polar bear Liu, Yanna Richardson, Evan S Derocher, Andrew E Lunn, Nicholas J Lehmler, Hans-Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
topic_facet |
environmental chemistry halogenated contaminants mass spectrometry nontarget discovery polar bear |
description |
Exposure of polar bears (Ursus maritimus) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with "fragmentation flagging" was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid-1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and these halogenated contaminants pose uncertain risks to this threatened species. |
format |
Article in Journal/Newspaper |
author |
Liu, Yanna Richardson, Evan S Derocher, Andrew E Lunn, Nicholas J Lehmler, Hans-Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W |
author_facet |
Liu, Yanna Richardson, Evan S Derocher, Andrew E Lunn, Nicholas J Lehmler, Hans-Joachim Li, Xueshu Zhang, Yifeng Cui, Julia Yue Cheng, Lihua Martin, Jonathan W |
author_sort |
Liu, Yanna |
title |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
title_short |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
title_full |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
title_fullStr |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
title_full_unstemmed |
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum. |
title_sort |
hundreds of unrecognized halogenated contaminants discovered in polar bear serum. |
publisher |
Wiley |
publishDate |
2018 |
url |
https://doi.org/10.1002/anie.201809906 https://pubmed.ncbi.nlm.nih.gov/30376612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394828/ |
genre |
Beaufort Sea Hudson Bay Ursus maritimus |
genre_facet |
Beaufort Sea Hudson Bay Ursus maritimus |
op_source |
Angew Chem Int Ed Engl ISSN:1521-3773 Volume:57 Issue:50 |
op_relation |
https://doi.org/10.1002/anie.201809906 https://pubmed.ncbi.nlm.nih.gov/30376612 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394828/ |
op_rights |
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
op_doi |
https://doi.org/10.1002/anie.201809906 |
container_title |
Angewandte Chemie International Edition |
container_volume |
57 |
container_issue |
50 |
container_start_page |
16401 |
op_container_end_page |
16406 |
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1810435457328087040 |