Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata.
Genetic diversity is unusually high at loci in the S-locus region of the self-incompatible species of the flowering plant, Arabidopsis lyrata, not just in the S loci themselves, but also at two nearby loci. In a previous study of a single natural population from Iceland, we attributed this elevated...
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Online Access: | https://doi.org/10.1534/genetics.107.072231 https://pubmed.ncbi.nlm.nih.gov/17565949 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950637/ |
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ftpubmed:17565949 2024-05-12T08:05:57+00:00 Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. Kamau, Esther Charlesworth, Brian Charlesworth, Deborah 2007 Aug https://doi.org/10.1534/genetics.107.072231 https://pubmed.ncbi.nlm.nih.gov/17565949 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950637/ eng eng Silverchair Information Systems https://doi.org/10.1534/genetics.107.072231 https://pubmed.ncbi.nlm.nih.gov/17565949 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950637/ Genetics ISSN:0016-6731 Volume:176 Issue:4 Journal Article Research Support, Non-U.S. Gov't 2007 ftpubmed https://doi.org/10.1534/genetics.107.072231 2024-04-14T16:01:00Z Genetic diversity is unusually high at loci in the S-locus region of the self-incompatible species of the flowering plant, Arabidopsis lyrata, not just in the S loci themselves, but also at two nearby loci. In a previous study of a single natural population from Iceland, we attributed this elevated polymorphism to linkage disequilibrium (LD) between variants at loci close to the S locus and the S alleles, which are maintained in the population by balancing selection. With the four S-flanking loci whose diversity we previously studied, we could not determine the extent of the region linked to the S loci in which neutral sites are affected. We also could not exclude the possibility of a population bottleneck, or of admixture, as causes of the LD. We have now studied four more distant loci flanking the S-locus region, and more populations, and we analyze the results using a theoretical model of the effect of balancing selection on diversity at linked neutral sites within and between different functional S-allelic classes. In the model, diversity is a function of the number of selectively maintained alleles and the recombination distances from the selectively maintained sites. We use the model to estimate the number of different functional S alleles, their turnover rate, and recombination rates between the S-locus region and other loci. Our estimates suggest that there is a small region of very low recombination surrounding the S-locus region. Article in Journal/Newspaper Iceland PubMed Central (PMC) Genetics 176 4 2357 2369 |
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English |
description |
Genetic diversity is unusually high at loci in the S-locus region of the self-incompatible species of the flowering plant, Arabidopsis lyrata, not just in the S loci themselves, but also at two nearby loci. In a previous study of a single natural population from Iceland, we attributed this elevated polymorphism to linkage disequilibrium (LD) between variants at loci close to the S locus and the S alleles, which are maintained in the population by balancing selection. With the four S-flanking loci whose diversity we previously studied, we could not determine the extent of the region linked to the S loci in which neutral sites are affected. We also could not exclude the possibility of a population bottleneck, or of admixture, as causes of the LD. We have now studied four more distant loci flanking the S-locus region, and more populations, and we analyze the results using a theoretical model of the effect of balancing selection on diversity at linked neutral sites within and between different functional S-allelic classes. In the model, diversity is a function of the number of selectively maintained alleles and the recombination distances from the selectively maintained sites. We use the model to estimate the number of different functional S alleles, their turnover rate, and recombination rates between the S-locus region and other loci. Our estimates suggest that there is a small region of very low recombination surrounding the S-locus region. |
format |
Article in Journal/Newspaper |
author |
Kamau, Esther Charlesworth, Brian Charlesworth, Deborah |
spellingShingle |
Kamau, Esther Charlesworth, Brian Charlesworth, Deborah Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
author_facet |
Kamau, Esther Charlesworth, Brian Charlesworth, Deborah |
author_sort |
Kamau, Esther |
title |
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
title_short |
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
title_full |
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
title_fullStr |
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
title_full_unstemmed |
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. |
title_sort |
linkage disequilibrium and recombination rate estimates in the self-incompatibility region of arabidopsis lyrata. |
publisher |
Silverchair Information Systems |
publishDate |
2007 |
url |
https://doi.org/10.1534/genetics.107.072231 https://pubmed.ncbi.nlm.nih.gov/17565949 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950637/ |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Genetics ISSN:0016-6731 Volume:176 Issue:4 |
op_relation |
https://doi.org/10.1534/genetics.107.072231 https://pubmed.ncbi.nlm.nih.gov/17565949 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950637/ |
op_doi |
https://doi.org/10.1534/genetics.107.072231 |
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Genetics |
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176 |
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4 |
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2357 |
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2369 |
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