Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia.
A total of 47 Caucasian duodenal ulcer patients and 680 healthy persons were investigated for HLA antigens of classes I and II. HLA antigens of the A, B series were sought using the microlymphocytotoxicity test, and HLA-DRBI was analysed by polymerase chain reaction. The study found associations of...
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ftpubmed:11507979 2024-09-15T18:02:07+00:00 Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. Kurilovich, S A Shlykova, L G Konenkov, V I 2001 Apr https://pubmed.ncbi.nlm.nih.gov/11507979 eng eng Atypon https://pubmed.ncbi.nlm.nih.gov/11507979 Int J Circumpolar Health ISSN:1239-9736 Volume:60 Issue:2 Comparative Study Journal Article 2001 ftpubmed 2024-07-24T16:03:00Z A total of 47 Caucasian duodenal ulcer patients and 680 healthy persons were investigated for HLA antigens of classes I and II. HLA antigens of the A, B series were sought using the microlymphocytotoxicity test, and HLA-DRBI was analysed by polymerase chain reaction. The study found associations of duodenal ulcer with HLA-A10, -B41 and different combinations of these alleles, whereas HLA-A9 was found to be protective. A relative risk of peptic ulcer was 3.03 in HLA-A10 (pcor < 0.05), and 7.78 in HLA-B41 (p < 0.001). The allele frequency A9 was higher in healthy controls (30.15%) than in Helicobacter pylori-positive patients with duodenal ulcer (10.64%, RR = 3.50, pcor < 0.05). The study showed that frequencies of alleles HLA-DR7 and HLA-A1/B12 were higher in Helicobacter pylori-positive duodenal ulcer patients with family history of peptic ulcer (RR = 4.00 and RR = 11.92, respectively p < 0.05). These data suggest that HLA may influence duodenal ulcer susceptibility and resistance, and according to the high prevalence of Helicobacter pylori (HP) infection in Siberian population (87.5%), this may occur through a non-HP infection pathway. Article in Journal/Newspaper Circumpolar Health Siberia PubMed Central (PMC) |
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Open Polar |
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PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
description |
A total of 47 Caucasian duodenal ulcer patients and 680 healthy persons were investigated for HLA antigens of classes I and II. HLA antigens of the A, B series were sought using the microlymphocytotoxicity test, and HLA-DRBI was analysed by polymerase chain reaction. The study found associations of duodenal ulcer with HLA-A10, -B41 and different combinations of these alleles, whereas HLA-A9 was found to be protective. A relative risk of peptic ulcer was 3.03 in HLA-A10 (pcor < 0.05), and 7.78 in HLA-B41 (p < 0.001). The allele frequency A9 was higher in healthy controls (30.15%) than in Helicobacter pylori-positive patients with duodenal ulcer (10.64%, RR = 3.50, pcor < 0.05). The study showed that frequencies of alleles HLA-DR7 and HLA-A1/B12 were higher in Helicobacter pylori-positive duodenal ulcer patients with family history of peptic ulcer (RR = 4.00 and RR = 11.92, respectively p < 0.05). These data suggest that HLA may influence duodenal ulcer susceptibility and resistance, and according to the high prevalence of Helicobacter pylori (HP) infection in Siberian population (87.5%), this may occur through a non-HP infection pathway. |
format |
Article in Journal/Newspaper |
author |
Kurilovich, S A Shlykova, L G Konenkov, V I |
spellingShingle |
Kurilovich, S A Shlykova, L G Konenkov, V I Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
author_facet |
Kurilovich, S A Shlykova, L G Konenkov, V I |
author_sort |
Kurilovich, S A |
title |
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
title_short |
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
title_full |
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
title_fullStr |
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
title_full_unstemmed |
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. |
title_sort |
immunogenetic factors of predisposition to duodenal ulcer in caucasian population of western siberia. |
publisher |
Atypon |
publishDate |
2001 |
url |
https://pubmed.ncbi.nlm.nih.gov/11507979 |
genre |
Circumpolar Health Siberia |
genre_facet |
Circumpolar Health Siberia |
op_source |
Int J Circumpolar Health ISSN:1239-9736 Volume:60 Issue:2 |
op_relation |
https://pubmed.ncbi.nlm.nih.gov/11507979 |
_version_ |
1810439267405529088 |