Grey wolf genomic history reveals a dual ancestry of dogs

The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when an...

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Published in:Nature
Main Authors: Bergström, A., Stanton, D., Taron, U., Frantz, L., Sinding, M., Ersmark, E., Pfrengle, S., Cassatt-Johnstone, M., Lebrasseur, O., Girdland-Flink, L., Fernandes, D., Ollivier, M., Speidel, L., Gopalakrishnan, S., Westbury, M., Ramos-Madrigal, J., Feuerborn, T., Reiter, E., Gretzinger, J., Münzel, S., Swali, P., Conard, N., Carøe, C., Haile, J., Linderholm, A., Androsov, S., Barnes, I., Baumann, C., Benecke, N., Bocherens, H., Brace, S., Carden, R., Drucker, D., Fedorov, S., Gasparik, M., Germonpré, M., Grigoriev, S., Groves, P., Hertwig, S., Ivanova, V., Janssens, L., Jennings, R., Kasparov, A., Kirillova, I., Kurmaniyazov, I., Kuzmin, Y., Kosintsev, P., Lázničková-Galetová, M., Leduc, C., Nikolskiy, P., Nussbaumer, M., O’Drisceoil, C., Orlando, L., Outram, A., Pavlova, E., Perri, A., Pilot, M., Pitulko, V., Plotnikov, V., Protopopov, A., Rehazek, A., Sablin, M., Seguin-Orlando, A., Storå, J., Verjux, C., Zaibert, V., Zazula, G., Crombé, P., Hansen, A., Willerslev, E., Leonard, J., Götherström, A., Pinhasi, R., Schuenemann, V., Hofreiter, M., Gilbert, M., Shapiro, B., Larson, G., Krause, J., Dalén, L., Skoglund, P.
Format: Article in Journal/Newspaper
Language:English
Published: 2022
Subjects:
Online Access:http://hdl.handle.net/21.11116/0000-000A-B8D7-4
http://hdl.handle.net/21.11116/0000-000B-A032-7
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spelling ftpubman:oai:pure.mpg.de:item_3395194 2023-08-27T04:08:54+02:00 Grey wolf genomic history reveals a dual ancestry of dogs Bergström, A. Stanton, D. Taron, U. Frantz, L. Sinding, M. Ersmark, E. Pfrengle, S. Cassatt-Johnstone, M. Lebrasseur, O. Girdland-Flink, L. Fernandes, D. Ollivier, M. Speidel, L. Gopalakrishnan, S. Westbury, M. Ramos-Madrigal, J. Feuerborn, T. Reiter, E. Gretzinger, J. Münzel, S. Swali, P. Conard, N. Carøe, C. Haile, J. Linderholm, A. Androsov, S. Barnes, I. Baumann, C. Benecke, N. Bocherens, H. Brace, S. Carden, R. Drucker, D. Fedorov, S. Gasparik, M. Germonpré, M. Grigoriev, S. Groves, P. Hertwig, S. Ivanova, V. Janssens, L. Jennings, R. Kasparov, A. Kirillova, I. Kurmaniyazov, I. Kuzmin, Y. Kosintsev, P. Lázničková-Galetová, M. Leduc, C. Nikolskiy, P. Nussbaumer, M. O’Drisceoil, C. Orlando, L. Outram, A. Pavlova, E. Perri, A. Pilot, M. Pitulko, V. Plotnikov, V. Protopopov, A. Rehazek, A. Sablin, M. Seguin-Orlando, A. Storå, J. Verjux, C. Zaibert, V. Zazula, G. Crombé, P. Hansen, A. Willerslev, E. Leonard, J. Götherström, A. Pinhasi, R. Schuenemann, V. Hofreiter, M. Gilbert, M. Shapiro, B. Larson, G. Krause, J. Dalén, L. Skoglund, P. 2022 application/pdf http://hdl.handle.net/21.11116/0000-000A-B8D7-4 http://hdl.handle.net/21.11116/0000-000B-A032-7 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-022-04824-9 http://hdl.handle.net/21.11116/0000-000A-B8D7-4 http://hdl.handle.net/21.11116/0000-000B-A032-7 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Nature info:eu-repo/semantics/article 2022 ftpubman https://doi.org/10.1038/s41586-022-04824-9 2023-08-02T01:26:09Z The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1–8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. Wolf genomes spanning 100,000 years Siberia as a source of global gene flow High connectivity in the Pleistocene Natural selection over 100,000 years Dog ancestry has eastern wolf affinities A second source for western dog ancestry Conclusion Methods Article in Journal/Newspaper Canis lupus Siberia Max Planck Society: MPG.PuRe Nature 607 7918 313 320
institution Open Polar
collection Max Planck Society: MPG.PuRe
op_collection_id ftpubman
language English
description The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1–8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. Wolf genomes spanning 100,000 years Siberia as a source of global gene flow High connectivity in the Pleistocene Natural selection over 100,000 years Dog ancestry has eastern wolf affinities A second source for western dog ancestry Conclusion Methods
format Article in Journal/Newspaper
author Bergström, A.
Stanton, D.
Taron, U.
Frantz, L.
Sinding, M.
Ersmark, E.
Pfrengle, S.
Cassatt-Johnstone, M.
Lebrasseur, O.
Girdland-Flink, L.
Fernandes, D.
Ollivier, M.
Speidel, L.
Gopalakrishnan, S.
Westbury, M.
Ramos-Madrigal, J.
Feuerborn, T.
Reiter, E.
Gretzinger, J.
Münzel, S.
Swali, P.
Conard, N.
Carøe, C.
Haile, J.
Linderholm, A.
Androsov, S.
Barnes, I.
Baumann, C.
Benecke, N.
Bocherens, H.
Brace, S.
Carden, R.
Drucker, D.
Fedorov, S.
Gasparik, M.
Germonpré, M.
Grigoriev, S.
Groves, P.
Hertwig, S.
Ivanova, V.
Janssens, L.
Jennings, R.
Kasparov, A.
Kirillova, I.
Kurmaniyazov, I.
Kuzmin, Y.
Kosintsev, P.
Lázničková-Galetová, M.
Leduc, C.
Nikolskiy, P.
Nussbaumer, M.
O’Drisceoil, C.
Orlando, L.
Outram, A.
Pavlova, E.
Perri, A.
Pilot, M.
Pitulko, V.
Plotnikov, V.
Protopopov, A.
Rehazek, A.
Sablin, M.
Seguin-Orlando, A.
Storå, J.
Verjux, C.
Zaibert, V.
Zazula, G.
Crombé, P.
Hansen, A.
Willerslev, E.
Leonard, J.
Götherström, A.
Pinhasi, R.
Schuenemann, V.
Hofreiter, M.
Gilbert, M.
Shapiro, B.
Larson, G.
Krause, J.
Dalén, L.
Skoglund, P.
spellingShingle Bergström, A.
Stanton, D.
Taron, U.
Frantz, L.
Sinding, M.
Ersmark, E.
Pfrengle, S.
Cassatt-Johnstone, M.
Lebrasseur, O.
Girdland-Flink, L.
Fernandes, D.
Ollivier, M.
Speidel, L.
Gopalakrishnan, S.
Westbury, M.
Ramos-Madrigal, J.
Feuerborn, T.
Reiter, E.
Gretzinger, J.
Münzel, S.
Swali, P.
Conard, N.
Carøe, C.
Haile, J.
Linderholm, A.
Androsov, S.
Barnes, I.
Baumann, C.
Benecke, N.
Bocherens, H.
Brace, S.
Carden, R.
Drucker, D.
Fedorov, S.
Gasparik, M.
Germonpré, M.
Grigoriev, S.
Groves, P.
Hertwig, S.
Ivanova, V.
Janssens, L.
Jennings, R.
Kasparov, A.
Kirillova, I.
Kurmaniyazov, I.
Kuzmin, Y.
Kosintsev, P.
Lázničková-Galetová, M.
Leduc, C.
Nikolskiy, P.
Nussbaumer, M.
O’Drisceoil, C.
Orlando, L.
Outram, A.
Pavlova, E.
Perri, A.
Pilot, M.
Pitulko, V.
Plotnikov, V.
Protopopov, A.
Rehazek, A.
Sablin, M.
Seguin-Orlando, A.
Storå, J.
Verjux, C.
Zaibert, V.
Zazula, G.
Crombé, P.
Hansen, A.
Willerslev, E.
Leonard, J.
Götherström, A.
Pinhasi, R.
Schuenemann, V.
Hofreiter, M.
Gilbert, M.
Shapiro, B.
Larson, G.
Krause, J.
Dalén, L.
Skoglund, P.
Grey wolf genomic history reveals a dual ancestry of dogs
author_facet Bergström, A.
Stanton, D.
Taron, U.
Frantz, L.
Sinding, M.
Ersmark, E.
Pfrengle, S.
Cassatt-Johnstone, M.
Lebrasseur, O.
Girdland-Flink, L.
Fernandes, D.
Ollivier, M.
Speidel, L.
Gopalakrishnan, S.
Westbury, M.
Ramos-Madrigal, J.
Feuerborn, T.
Reiter, E.
Gretzinger, J.
Münzel, S.
Swali, P.
Conard, N.
Carøe, C.
Haile, J.
Linderholm, A.
Androsov, S.
Barnes, I.
Baumann, C.
Benecke, N.
Bocherens, H.
Brace, S.
Carden, R.
Drucker, D.
Fedorov, S.
Gasparik, M.
Germonpré, M.
Grigoriev, S.
Groves, P.
Hertwig, S.
Ivanova, V.
Janssens, L.
Jennings, R.
Kasparov, A.
Kirillova, I.
Kurmaniyazov, I.
Kuzmin, Y.
Kosintsev, P.
Lázničková-Galetová, M.
Leduc, C.
Nikolskiy, P.
Nussbaumer, M.
O’Drisceoil, C.
Orlando, L.
Outram, A.
Pavlova, E.
Perri, A.
Pilot, M.
Pitulko, V.
Plotnikov, V.
Protopopov, A.
Rehazek, A.
Sablin, M.
Seguin-Orlando, A.
Storå, J.
Verjux, C.
Zaibert, V.
Zazula, G.
Crombé, P.
Hansen, A.
Willerslev, E.
Leonard, J.
Götherström, A.
Pinhasi, R.
Schuenemann, V.
Hofreiter, M.
Gilbert, M.
Shapiro, B.
Larson, G.
Krause, J.
Dalén, L.
Skoglund, P.
author_sort Bergström, A.
title Grey wolf genomic history reveals a dual ancestry of dogs
title_short Grey wolf genomic history reveals a dual ancestry of dogs
title_full Grey wolf genomic history reveals a dual ancestry of dogs
title_fullStr Grey wolf genomic history reveals a dual ancestry of dogs
title_full_unstemmed Grey wolf genomic history reveals a dual ancestry of dogs
title_sort grey wolf genomic history reveals a dual ancestry of dogs
publishDate 2022
url http://hdl.handle.net/21.11116/0000-000A-B8D7-4
http://hdl.handle.net/21.11116/0000-000B-A032-7
genre Canis lupus
Siberia
genre_facet Canis lupus
Siberia
op_source Nature
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http://hdl.handle.net/21.11116/0000-000B-A032-7
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