Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales
The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth....
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ftpubman:oai:pure.mpg.de:item_3238957 2023-08-27T04:08:38+02:00 Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales Springer, M. Emerling, C. Gatesy, J. Randall, J. Collin, M. Hecker, N. Hiller, M. Delsuc, F. 2019-01-23 http://hdl.handle.net/21.11116/0000-0006-9568-D unknown info:eu-repo/semantics/altIdentifier/doi/10.1186/s12862-019-1359-6 info:eu-repo/semantics/altIdentifier/pmid/30674270 http://hdl.handle.net/21.11116/0000-0006-9568-D BMC evolutionary biology Living matter info:eu-repo/semantics/article 2019 ftpubman https://doi.org/10.1186/s12862-019-1359-6 2023-08-02T00:55:20Z The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth. Here, we leverage the power of natural selection to test competing hypotheses that ODAM is tooth-specific versus pleiotropic. Specifically, we compiled and screened complete protein-coding sequences, plus sequences for flanking intronic regions, for ODAM in 165 placental mammals to determine if this gene contains inactivating mutations in lineages that either lack teeth (baleen whales, pangolins, anteaters) or lack enamel on their teeth (aardvarks, sloths, armadillos), as would be expected if the only essential functions of ODAM are related to tooth development and the adhesion of the gingival junctional epithelium to the enamel tooth surface. Article in Journal/Newspaper baleen whales toothed whales Max Planck Society: MPG.PuRe BMC Evolutionary Biology 19 1 |
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Living matter Springer, M. Emerling, C. Gatesy, J. Randall, J. Collin, M. Hecker, N. Hiller, M. Delsuc, F. Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
topic_facet |
Living matter |
description |
The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth. Here, we leverage the power of natural selection to test competing hypotheses that ODAM is tooth-specific versus pleiotropic. Specifically, we compiled and screened complete protein-coding sequences, plus sequences for flanking intronic regions, for ODAM in 165 placental mammals to determine if this gene contains inactivating mutations in lineages that either lack teeth (baleen whales, pangolins, anteaters) or lack enamel on their teeth (aardvarks, sloths, armadillos), as would be expected if the only essential functions of ODAM are related to tooth development and the adhesion of the gingival junctional epithelium to the enamel tooth surface. |
format |
Article in Journal/Newspaper |
author |
Springer, M. Emerling, C. Gatesy, J. Randall, J. Collin, M. Hecker, N. Hiller, M. Delsuc, F. |
author_facet |
Springer, M. Emerling, C. Gatesy, J. Randall, J. Collin, M. Hecker, N. Hiller, M. Delsuc, F. |
author_sort |
Springer, M. |
title |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_short |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_full |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_fullStr |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_full_unstemmed |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_sort |
odontogenic ameloblast-associated (odam) is inactivated in toothless/enamelless placental mammals and toothed whales |
publishDate |
2019 |
url |
http://hdl.handle.net/21.11116/0000-0006-9568-D |
genre |
baleen whales toothed whales |
genre_facet |
baleen whales toothed whales |
op_source |
BMC evolutionary biology |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12862-019-1359-6 info:eu-repo/semantics/altIdentifier/pmid/30674270 http://hdl.handle.net/21.11116/0000-0006-9568-D |
op_doi |
https://doi.org/10.1186/s12862-019-1359-6 |
container_title |
BMC Evolutionary Biology |
container_volume |
19 |
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1 |
_version_ |
1775349484053594112 |