DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

• Published in: RESEARCH RESULT Pharmacology and Clinical Pharmacology
• Main Authors: Buzov,Andrey, Kulikov,Alexandr, Avtina,Tatyana, Pokrovskii,Mikhail, Osipova,Ol'ga
• Format: Article in Journal/Newspaper
• Language: English
• Published: Belgorod National Research University 2016
• Subjects: antidiabetic agent; С7070; the blood plasma of rats; high-performance liquid chromatography; mass spectrometric detection; validation; Carbonic acid
• Online Access: https://doi.org/10.18413/2313-8971-2016-2-1-52-57; https://rrpharmacology.ru/article/31041/

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.