Advances in influenza virus sialidase inhibitors

• Main Authors: Niu Youhong, Cao Xiaoping, Ye Xinshan
• Other Authors: Niu, YH (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China., Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China., Peking Univ, Hlth Sci Ctr, Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China.
• Format: Journal/Newspaper
• Language: English
• Published: 化学进展 2007
• Subjects: sialidase inhibitors; zanamivir; antivirus; avian flu; POTENT ANTIINFLUENZA ACTIVITY; SELECTIN-LIGAND ESL-1; NEURAMINIDASE INHIBITORS; ACID ANALOGS; STRUCTURAL-ANALYSIS; BENZOIC-ACID; H5N1 VIRUSES; HONG-KONG; DERIVATIVES; DESIGN; Avian flu
• Online Access: https://hdl.handle.net/20.500.11897/397851

Due to the recent emergence of avian flu, the possibility of a pandemic wave of life-threatening flu is a serious worldwide concern. Tamiflu, one of the outstanding successes of rational drug design, becomes a star drug that inhibits virus sialidase (neuraminidase), an enzyme crucial for the release and spread of the influenza virus from infected cells. This event stimulated many people to seek a share of the potentially huge flu drug market. On the basis of a brief introduction of sialidases and their functions, this review summarizes the recent advances in influenza virus sialidase inhibitors with particular focus on the transition state-based design, the synthetic scaffold types of carbohydrate mimetics, and the structure-activity relationships of structure-based sialidase inhibitors. Since sialidases are involved in the pathogenesis of a wide range of other diseases, the knowledge and expertise gained from the influenza study could be used in the design of other drugs, given that they all share certain structural features. Chemistry, Multidisciplinary SCI(E) 中文核心期刊要目总览(PKU) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) 0 2-3 420-430 19