Advances in influenza virus sialidase inhibitors
Due to the recent emergence of avian flu, the possibility of a pandemic wave of life-threatening flu is a serious worldwide concern. Tamiflu, one of the outstanding successes of rational drug design, becomes a star drug that inhibits virus sialidase (neuraminidase), an enzyme crucial for the release...
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化学进展
2007
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ftpekinguniv:oai:localhost:20.500.11897/397851 2023-05-15T15:34:19+02:00 Advances in influenza virus sialidase inhibitors Niu Youhong Cao Xiaoping Ye Xinshan Niu, YH (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Peking Univ, Hlth Sci Ctr, Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. 2007 https://hdl.handle.net/20.500.11897/397851 en eng 化学进展 PROGRESS IN CHEMISTRY.2007,19,(2-3),420-430. 968934 1005-281X http://hdl.handle.net/20.500.11897/397851 WOS:000245139600028 SCI sialidase inhibitors zanamivir antivirus avian flu POTENT ANTIINFLUENZA ACTIVITY SELECTIN-LIGAND ESL-1 NEURAMINIDASE INHIBITORS ACID ANALOGS STRUCTURAL-ANALYSIS BENZOIC-ACID H5N1 VIRUSES HONG-KONG DERIVATIVES DESIGN Journal 2007 ftpekinguniv https://doi.org/20.500.11897/397851 2021-08-01T10:23:59Z Due to the recent emergence of avian flu, the possibility of a pandemic wave of life-threatening flu is a serious worldwide concern. Tamiflu, one of the outstanding successes of rational drug design, becomes a star drug that inhibits virus sialidase (neuraminidase), an enzyme crucial for the release and spread of the influenza virus from infected cells. This event stimulated many people to seek a share of the potentially huge flu drug market. On the basis of a brief introduction of sialidases and their functions, this review summarizes the recent advances in influenza virus sialidase inhibitors with particular focus on the transition state-based design, the synthetic scaffold types of carbohydrate mimetics, and the structure-activity relationships of structure-based sialidase inhibitors. Since sialidases are involved in the pathogenesis of a wide range of other diseases, the knowledge and expertise gained from the influenza study could be used in the design of other drugs, given that they all share certain structural features. Chemistry, Multidisciplinary SCI(E) 中文核心期刊要目总览(PKU) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) 0 2-3 420-430 19 Journal/Newspaper Avian flu Peking University Institutional Repository (PKU IR) |
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Peking University Institutional Repository (PKU IR) |
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English |
topic |
sialidase inhibitors zanamivir antivirus avian flu POTENT ANTIINFLUENZA ACTIVITY SELECTIN-LIGAND ESL-1 NEURAMINIDASE INHIBITORS ACID ANALOGS STRUCTURAL-ANALYSIS BENZOIC-ACID H5N1 VIRUSES HONG-KONG DERIVATIVES DESIGN |
spellingShingle |
sialidase inhibitors zanamivir antivirus avian flu POTENT ANTIINFLUENZA ACTIVITY SELECTIN-LIGAND ESL-1 NEURAMINIDASE INHIBITORS ACID ANALOGS STRUCTURAL-ANALYSIS BENZOIC-ACID H5N1 VIRUSES HONG-KONG DERIVATIVES DESIGN Niu Youhong Cao Xiaoping Ye Xinshan Advances in influenza virus sialidase inhibitors |
topic_facet |
sialidase inhibitors zanamivir antivirus avian flu POTENT ANTIINFLUENZA ACTIVITY SELECTIN-LIGAND ESL-1 NEURAMINIDASE INHIBITORS ACID ANALOGS STRUCTURAL-ANALYSIS BENZOIC-ACID H5N1 VIRUSES HONG-KONG DERIVATIVES DESIGN |
description |
Due to the recent emergence of avian flu, the possibility of a pandemic wave of life-threatening flu is a serious worldwide concern. Tamiflu, one of the outstanding successes of rational drug design, becomes a star drug that inhibits virus sialidase (neuraminidase), an enzyme crucial for the release and spread of the influenza virus from infected cells. This event stimulated many people to seek a share of the potentially huge flu drug market. On the basis of a brief introduction of sialidases and their functions, this review summarizes the recent advances in influenza virus sialidase inhibitors with particular focus on the transition state-based design, the synthetic scaffold types of carbohydrate mimetics, and the structure-activity relationships of structure-based sialidase inhibitors. Since sialidases are involved in the pathogenesis of a wide range of other diseases, the knowledge and expertise gained from the influenza study could be used in the design of other drugs, given that they all share certain structural features. Chemistry, Multidisciplinary SCI(E) 中文核心期刊要目总览(PKU) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) 0 2-3 420-430 19 |
author2 |
Niu, YH (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Peking Univ, Hlth Sci Ctr, Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. |
format |
Journal/Newspaper |
author |
Niu Youhong Cao Xiaoping Ye Xinshan |
author_facet |
Niu Youhong Cao Xiaoping Ye Xinshan |
author_sort |
Niu Youhong |
title |
Advances in influenza virus sialidase inhibitors |
title_short |
Advances in influenza virus sialidase inhibitors |
title_full |
Advances in influenza virus sialidase inhibitors |
title_fullStr |
Advances in influenza virus sialidase inhibitors |
title_full_unstemmed |
Advances in influenza virus sialidase inhibitors |
title_sort |
advances in influenza virus sialidase inhibitors |
publisher |
化学进展 |
publishDate |
2007 |
url |
https://hdl.handle.net/20.500.11897/397851 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
SCI |
op_relation |
PROGRESS IN CHEMISTRY.2007,19,(2-3),420-430. 968934 1005-281X http://hdl.handle.net/20.500.11897/397851 WOS:000245139600028 |
op_doi |
https://doi.org/20.500.11897/397851 |
_version_ |
1766364756342472704 |