Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways
The impact of pCO2 driven ocean acidification on marine bivalve immunity remains poorly understood. To date, this impact has only been investigated in a few bivalve species and the underlying molecular mechanism remains unknown. In the present study, the effects of the realistic future ocean pCO2 le...
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ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.861971 2024-09-15T18:27:49+00:00 Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways Liu, Saixi Shi, Wei Guo, Cheng Zhao, Xinguo Han, Yu Peng, Chao Chai, Xueliang Liu, Guangxu 2016 text/tab-separated-values, 1503 data points https://doi.pangaea.de/10.1594/PANGAEA.861971 https://doi.org/10.1594/PANGAEA.861971 en eng PANGAEA Gattuso, Jean-Pierre; Epitalon, Jean-Marie; Lavigne, Héloïse (2015): seacarb: seawater carbonate chemistry with R. R package version 3.0.8. https://cran.r-project.org/package=seacarb https://doi.pangaea.de/10.1594/PANGAEA.861971 https://doi.org/10.1594/PANGAEA.861971 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess Supplement to: Liu, Saixi; Shi, Wei; Guo, Cheng; Zhao, Xinguo; Han, Yu; Peng, Chao; Chai, Xueliang; Liu, Guangxu (2016): Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways. Fish & Shellfish Immunology, 54, 322-327, https://doi.org/10.1016/j.fsi.2016.04.030 Alkalinity total standard error Animalia Aragonite saturation state Benthic animals Benthos Bicarbonate ion Brackish waters Calcite saturation state Calculated using CO2SYS Calculated using seacarb after Nisumaa et al. (2010) Carbon inorganic dissolved Carbonate ion Carbonate system computation flag Carbon dioxide Containers and aquaria (20-1000 L or < 1 m**2) Date Fugacity of carbon dioxide (water) at sea surface temperature (wet air) Gene expression (incl. proteomics) Gene name Growth/Morphology Height Hemocyte count Immunology/Self-protection Laboratory experiment Mollusca mRNA gene expression relative North Pacific OA-ICC dataset 2016 ftpangaea https://doi.org/10.1594/PANGAEA.86197110.1016/j.fsi.2016.04.030 2024-07-24T02:31:33Z The impact of pCO2 driven ocean acidification on marine bivalve immunity remains poorly understood. To date, this impact has only been investigated in a few bivalve species and the underlying molecular mechanism remains unknown. In the present study, the effects of the realistic future ocean pCO2 levels (pH at 8.1, 7.8, and 7.4) on the total number of haemocyte cells (THC), phagocytosis status, blood cell types composition, and expression levels of twelve genes from the NF-kappa beta signaling and toll-like receptor pathways of a typical bottom burrowing bivalve, blood clam (Tegillarca granosa), were investigated. The results obtained showed that while both THC number and phagocytosis frequency were significantly reduced, the percentage of red and basophil granulocytes were significantly decreased and increased, respectively, upon exposure to elevated pCO2. In addition, exposure to pCO2 acidified seawater generally led to a significant down-regulation in the inducer and key response genes of NF-kappa beta signaling and toll-like receptor pathways. The results of the present study revealed that ocean acidification may hamper immune responses of the bivalve T. granosa which subsequently render individuals more susceptible to pathogens attacks such as those from virus and bacteria. Dataset Ocean acidification PANGAEA - Data Publisher for Earth & Environmental Science |
institution |
Open Polar |
collection |
PANGAEA - Data Publisher for Earth & Environmental Science |
op_collection_id |
ftpangaea |
language |
English |
topic |
Alkalinity total standard error Animalia Aragonite saturation state Benthic animals Benthos Bicarbonate ion Brackish waters Calcite saturation state Calculated using CO2SYS Calculated using seacarb after Nisumaa et al. (2010) Carbon inorganic dissolved Carbonate ion Carbonate system computation flag Carbon dioxide Containers and aquaria (20-1000 L or < 1 m**2) Date Fugacity of carbon dioxide (water) at sea surface temperature (wet air) Gene expression (incl. proteomics) Gene name Growth/Morphology Height Hemocyte count Immunology/Self-protection Laboratory experiment Mollusca mRNA gene expression relative North Pacific OA-ICC |
spellingShingle |
Alkalinity total standard error Animalia Aragonite saturation state Benthic animals Benthos Bicarbonate ion Brackish waters Calcite saturation state Calculated using CO2SYS Calculated using seacarb after Nisumaa et al. (2010) Carbon inorganic dissolved Carbonate ion Carbonate system computation flag Carbon dioxide Containers and aquaria (20-1000 L or < 1 m**2) Date Fugacity of carbon dioxide (water) at sea surface temperature (wet air) Gene expression (incl. proteomics) Gene name Growth/Morphology Height Hemocyte count Immunology/Self-protection Laboratory experiment Mollusca mRNA gene expression relative North Pacific OA-ICC Liu, Saixi Shi, Wei Guo, Cheng Zhao, Xinguo Han, Yu Peng, Chao Chai, Xueliang Liu, Guangxu Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
topic_facet |
Alkalinity total standard error Animalia Aragonite saturation state Benthic animals Benthos Bicarbonate ion Brackish waters Calcite saturation state Calculated using CO2SYS Calculated using seacarb after Nisumaa et al. (2010) Carbon inorganic dissolved Carbonate ion Carbonate system computation flag Carbon dioxide Containers and aquaria (20-1000 L or < 1 m**2) Date Fugacity of carbon dioxide (water) at sea surface temperature (wet air) Gene expression (incl. proteomics) Gene name Growth/Morphology Height Hemocyte count Immunology/Self-protection Laboratory experiment Mollusca mRNA gene expression relative North Pacific OA-ICC |
description |
The impact of pCO2 driven ocean acidification on marine bivalve immunity remains poorly understood. To date, this impact has only been investigated in a few bivalve species and the underlying molecular mechanism remains unknown. In the present study, the effects of the realistic future ocean pCO2 levels (pH at 8.1, 7.8, and 7.4) on the total number of haemocyte cells (THC), phagocytosis status, blood cell types composition, and expression levels of twelve genes from the NF-kappa beta signaling and toll-like receptor pathways of a typical bottom burrowing bivalve, blood clam (Tegillarca granosa), were investigated. The results obtained showed that while both THC number and phagocytosis frequency were significantly reduced, the percentage of red and basophil granulocytes were significantly decreased and increased, respectively, upon exposure to elevated pCO2. In addition, exposure to pCO2 acidified seawater generally led to a significant down-regulation in the inducer and key response genes of NF-kappa beta signaling and toll-like receptor pathways. The results of the present study revealed that ocean acidification may hamper immune responses of the bivalve T. granosa which subsequently render individuals more susceptible to pathogens attacks such as those from virus and bacteria. |
format |
Dataset |
author |
Liu, Saixi Shi, Wei Guo, Cheng Zhao, Xinguo Han, Yu Peng, Chao Chai, Xueliang Liu, Guangxu |
author_facet |
Liu, Saixi Shi, Wei Guo, Cheng Zhao, Xinguo Han, Yu Peng, Chao Chai, Xueliang Liu, Guangxu |
author_sort |
Liu, Saixi |
title |
Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
title_short |
Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
title_full |
Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
title_fullStr |
Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
title_full_unstemmed |
Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways |
title_sort |
ocean acidification weakens the immune response of blood clam through hampering the nf-kappa beta and toll-like receptor pathways |
publisher |
PANGAEA |
publishDate |
2016 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.861971 https://doi.org/10.1594/PANGAEA.861971 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Supplement to: Liu, Saixi; Shi, Wei; Guo, Cheng; Zhao, Xinguo; Han, Yu; Peng, Chao; Chai, Xueliang; Liu, Guangxu (2016): Ocean acidification weakens the immune response of blood clam through hampering the NF-kappa beta and toll-like receptor pathways. Fish & Shellfish Immunology, 54, 322-327, https://doi.org/10.1016/j.fsi.2016.04.030 |
op_relation |
Gattuso, Jean-Pierre; Epitalon, Jean-Marie; Lavigne, Héloïse (2015): seacarb: seawater carbonate chemistry with R. R package version 3.0.8. https://cran.r-project.org/package=seacarb https://doi.pangaea.de/10.1594/PANGAEA.861971 https://doi.org/10.1594/PANGAEA.861971 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1594/PANGAEA.86197110.1016/j.fsi.2016.04.030 |
_version_ |
1810469087139069952 |