NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae
An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. The...
Main Authors: | , |
---|---|
Format: | Dataset |
Language: | English |
Published: |
PANGAEA
2016
|
Subjects: | |
Online Access: | https://doi.pangaea.de/10.1594/PANGAEA.856706 https://doi.org/10.1594/PANGAEA.856706 |
id |
ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.856706 |
---|---|
record_format |
openpolar |
spelling |
ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.856706 2023-05-15T14:03:05+02:00 NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae Imhoff, Johannes F Wiese, Jutta 2016-01-07 application/pdf, 49.3 kBytes https://doi.pangaea.de/10.1594/PANGAEA.856706 https://doi.org/10.1594/PANGAEA.856706 en eng PANGAEA https://doi.pangaea.de/10.1594/PANGAEA.856706 https://doi.org/10.1594/PANGAEA.856706 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess CC-BY Supplement to: Wu, Bin; Wiese, Jutta; Labes, Antje; Kramer, Annemarie; Schmaljohann, Rolf; Imhoff, Johannes F (2015): Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae. Marine Drugs, 13(8), 4617-4632, https://doi.org/10.3390/md13084617 Dataset 2016 ftpangaea https://doi.org/10.1594/PANGAEA.856706 https://doi.org/10.3390/md13084617 2023-01-20T09:06:41Z An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) µM, respectively, against methicillin-resistant Staphylococcus aureus. Dataset Antarc* Antarctic PANGAEA - Data Publisher for Earth & Environmental Science Antarctic The Antarctic |
institution |
Open Polar |
collection |
PANGAEA - Data Publisher for Earth & Environmental Science |
op_collection_id |
ftpangaea |
language |
English |
description |
An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) µM, respectively, against methicillin-resistant Staphylococcus aureus. |
format |
Dataset |
author |
Imhoff, Johannes F Wiese, Jutta |
spellingShingle |
Imhoff, Johannes F Wiese, Jutta NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
author_facet |
Imhoff, Johannes F Wiese, Jutta |
author_sort |
Imhoff, Johannes F |
title |
NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
title_short |
NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
title_full |
NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
title_fullStr |
NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
title_full_unstemmed |
NMR spectrum of lindgomycin from a Marine Fungus of the Lindgomycetaceae |
title_sort |
nmr spectrum of lindgomycin from a marine fungus of the lindgomycetaceae |
publisher |
PANGAEA |
publishDate |
2016 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.856706 https://doi.org/10.1594/PANGAEA.856706 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Supplement to: Wu, Bin; Wiese, Jutta; Labes, Antje; Kramer, Annemarie; Schmaljohann, Rolf; Imhoff, Johannes F (2015): Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae. Marine Drugs, 13(8), 4617-4632, https://doi.org/10.3390/md13084617 |
op_relation |
https://doi.pangaea.de/10.1594/PANGAEA.856706 https://doi.org/10.1594/PANGAEA.856706 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1594/PANGAEA.856706 https://doi.org/10.3390/md13084617 |
_version_ |
1766273598577704960 |