(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland

We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia,...

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Bibliographic Details
Main Authors: Sonne, Christian, Leifsson, Pall S, Dietz, Rune, Kirkegaard, Maja, Jensen, Asger, Shahmiri, Soheila, Letcher, Robert J
Format: Dataset
Language:English
Published: PANGAEA 2008
Subjects:
Aasiaat_Canis
Alanine aminotransferase
Alkaline phosphatase
Aspartate aminotransferase
Bile acids
Bilirubin
Biological sample
BIOS
Disko Bay
Greenland
International Polar Year (2007-2008)
IPY
Lactate dehydrogenase
Liver
mass
Polychlorinated biphenyl
standard deviation
Sample amount
subset
Species
Treatment
Aasiaat
Balaenoptera acutorostrata
International Polar Year
minke whale
Ursus maritimus
Online Access:https://doi.pangaea.de/10.1594/PANGAEA.837324
https://doi.org/10.1594/PANGAEA.837324
Description
Summary:We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia, and vascular leukocyte infiltrations was significantly higher in the exposed group (all Chi-square: p<0.05). In case of granulomas, the frequency was significantly highest in the bitches (P generation) while the prevalence of portal fibrosis was highest in the F generation (pups) (both Chi-square: p<0.05). No significant difference between exposed and controls was found for bile acid, ALAT, and ALKP, while ASAT and LDH were significantly highest in the control group (both ANOVA: p<0.05). We therefore suggest that a daily intake of 50-200 g environmentally organohalogen polluted minke whale blubber can cause liver lesions in Greenland sledge dogs. It is reasonable to infer that other apex predators such as polar bears (Ursus maritimus) and humans may suffer from similar impacts.

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