Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals
The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal (Halichoerus grypus) and ringed seal (Phoca hispida botnica) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological...
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2008
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ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.819419 2023-05-15T16:53:57+02:00 Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir W MEDIAN LATITUDE: 62.047433 * MEDIAN LONGITUDE: 3.831833 * SOUTH-BOUND LATITUDE: 43.950000 * WEST-BOUND LONGITUDE: -59.916000 * NORTH-BOUND LATITUDE: 78.900000 * EAST-BOUND LONGITUDE: 24.333000 2008-09-17 application/zip, 2 datasets https://doi.pangaea.de/10.1594/PANGAEA.819419 https://doi.org/10.1594/PANGAEA.819419 en eng PANGAEA https://doi.pangaea.de/10.1594/PANGAEA.819419 https://doi.org/10.1594/PANGAEA.819419 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess CC-BY Supplement to: Routti, Heli; Nyman, Madeleine; Jenssen, Bjørn Munro; Bäckman, Christina; Koistinen, Jaana; Gabrielsen, Geir W (2008): Bone-related effects of contaminants in seals may be associated with vitamin D and thyroid hormones. Environmental Toxicology and Chemistry, 27(4), 873, https://doi.org/10.1897/07-139.1 International Polar Year (2007-2008) IPY Dataset 2008 ftpangaea https://doi.org/10.1594/PANGAEA.819419 https://doi.org/10.1897/07-139.1 2023-01-20T07:33:08Z The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal (Halichoerus grypus) and ringed seal (Phoca hispida botnica) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological mechanisms leading to these pathological changes are not yet fully understood. The present study investigated the relationship between the individual contaminant load and bone- and thyroid-related effects in adult gray seals (n = 30) and ringed seals (n = 46) in the highly contaminated Baltic Sea and in reference areas (Sable Island, Canada, and Svalbard, Norway). In the gray seals, multivariate and correlation analyses revealed a clear relationship between circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D), calcium, phosphate, and thyroid hormone (TH) levels and hepatic PCB and DDT load, which suggests contaminant-mediated disruption of the bone and thyroid homeostasis. Contaminants may depress 1,25(OH)2D levels or lead to hyperthyroidism, which may cause bone resorption. In the ringed seals, associations between circulating 1,25(OH)2D, THs, and hepatic contaminants were less prominent. These results suggest that bone lesions observed in the Baltic gray seals may be associated with contaminant-mediated vitamin D and thyroid disruption. Dataset International Polar Year IPY Phoca hispida ringed seal Svalbard PANGAEA - Data Publisher for Earth & Environmental Science Canada Norway Svalbard ENVELOPE(-59.916000,24.333000,78.900000,43.950000) |
institution |
Open Polar |
collection |
PANGAEA - Data Publisher for Earth & Environmental Science |
op_collection_id |
ftpangaea |
language |
English |
topic |
International Polar Year (2007-2008) IPY |
spellingShingle |
International Polar Year (2007-2008) IPY Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir W Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
topic_facet |
International Polar Year (2007-2008) IPY |
description |
The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal (Halichoerus grypus) and ringed seal (Phoca hispida botnica) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological mechanisms leading to these pathological changes are not yet fully understood. The present study investigated the relationship between the individual contaminant load and bone- and thyroid-related effects in adult gray seals (n = 30) and ringed seals (n = 46) in the highly contaminated Baltic Sea and in reference areas (Sable Island, Canada, and Svalbard, Norway). In the gray seals, multivariate and correlation analyses revealed a clear relationship between circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D), calcium, phosphate, and thyroid hormone (TH) levels and hepatic PCB and DDT load, which suggests contaminant-mediated disruption of the bone and thyroid homeostasis. Contaminants may depress 1,25(OH)2D levels or lead to hyperthyroidism, which may cause bone resorption. In the ringed seals, associations between circulating 1,25(OH)2D, THs, and hepatic contaminants were less prominent. These results suggest that bone lesions observed in the Baltic gray seals may be associated with contaminant-mediated vitamin D and thyroid disruption. |
format |
Dataset |
author |
Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir W |
author_facet |
Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir W |
author_sort |
Routti, Heli |
title |
Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
title_short |
Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
title_full |
Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
title_fullStr |
Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
title_full_unstemmed |
Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals |
title_sort |
concentrations of pcbs, ddt and thyroid hormones in gray (halichoerus grypus) and ringed (phoca hispida) seals |
publisher |
PANGAEA |
publishDate |
2008 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.819419 https://doi.org/10.1594/PANGAEA.819419 |
op_coverage |
MEDIAN LATITUDE: 62.047433 * MEDIAN LONGITUDE: 3.831833 * SOUTH-BOUND LATITUDE: 43.950000 * WEST-BOUND LONGITUDE: -59.916000 * NORTH-BOUND LATITUDE: 78.900000 * EAST-BOUND LONGITUDE: 24.333000 |
long_lat |
ENVELOPE(-59.916000,24.333000,78.900000,43.950000) |
geographic |
Canada Norway Svalbard |
geographic_facet |
Canada Norway Svalbard |
genre |
International Polar Year IPY Phoca hispida ringed seal Svalbard |
genre_facet |
International Polar Year IPY Phoca hispida ringed seal Svalbard |
op_source |
Supplement to: Routti, Heli; Nyman, Madeleine; Jenssen, Bjørn Munro; Bäckman, Christina; Koistinen, Jaana; Gabrielsen, Geir W (2008): Bone-related effects of contaminants in seals may be associated with vitamin D and thyroid hormones. Environmental Toxicology and Chemistry, 27(4), 873, https://doi.org/10.1897/07-139.1 |
op_relation |
https://doi.pangaea.de/10.1594/PANGAEA.819419 https://doi.org/10.1594/PANGAEA.819419 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1594/PANGAEA.819419 https://doi.org/10.1897/07-139.1 |
_version_ |
1766044547718053888 |