Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 contro...
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ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.812009 2024-09-15T18:01:16+00:00 Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe LATITUDE: 68.719000 * LONGITUDE: -52.793000 2011 application/zip, 3 datasets https://doi.pangaea.de/10.1594/PANGAEA.812009 https://doi.org/10.1594/PANGAEA.812009 en eng PANGAEA https://doi.pangaea.de/10.1594/PANGAEA.812009 https://doi.org/10.1594/PANGAEA.812009 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess Supplement to: Kirkegaard, Maja; Sonne, Christian; Dietz, Rune; Letcher, Robert J; Jensen, Asger L; Hansen, Signe Stige; Jenssen, Bjørn Munro; Grandjean, Philippe (2011): Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds. Ecotoxicology and Environmental Safety, 74(1), 157-163, https://doi.org/10.1016/j.ecoenv.2010.08.040 Aasiaat_Canis Biological sample BIOS Disko Bay Greenland International Polar Year (2007-2008) IPY dataset publication series 2011 ftpangaea https://doi.org/10.1594/PANGAEA.81200910.1016/j.ecoenv.2010.08.040 2024-07-24T02:31:21Z As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. Other/Unknown Material Canis lupus Disko Bay Greenland International Polar Year IPY minke whale PANGAEA - Data Publisher for Earth & Environmental Science ENVELOPE(-52.793000,-52.793000,68.719000,68.719000) |
institution |
Open Polar |
collection |
PANGAEA - Data Publisher for Earth & Environmental Science |
op_collection_id |
ftpangaea |
language |
English |
topic |
Aasiaat_Canis Biological sample BIOS Disko Bay Greenland International Polar Year (2007-2008) IPY |
spellingShingle |
Aasiaat_Canis Biological sample BIOS Disko Bay Greenland International Polar Year (2007-2008) IPY Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
topic_facet |
Aasiaat_Canis Biological sample BIOS Disko Bay Greenland International Polar Year (2007-2008) IPY |
description |
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. |
format |
Other/Unknown Material |
author |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
author_facet |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J Jensen, Asger L Hansen, Signe Stige Jenssen, Bjørn Munro Grandjean, Philippe |
author_sort |
Kirkegaard, Maja |
title |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
title_short |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
title_full |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
title_fullStr |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
title_full_unstemmed |
Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber |
title_sort |
thyroid hormone and gland status of greenland sledge dogs (canis lupus familiaris) exposed to contaminated blubber |
publisher |
PANGAEA |
publishDate |
2011 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.812009 https://doi.org/10.1594/PANGAEA.812009 |
op_coverage |
LATITUDE: 68.719000 * LONGITUDE: -52.793000 |
long_lat |
ENVELOPE(-52.793000,-52.793000,68.719000,68.719000) |
genre |
Canis lupus Disko Bay Greenland International Polar Year IPY minke whale |
genre_facet |
Canis lupus Disko Bay Greenland International Polar Year IPY minke whale |
op_source |
Supplement to: Kirkegaard, Maja; Sonne, Christian; Dietz, Rune; Letcher, Robert J; Jensen, Asger L; Hansen, Signe Stige; Jenssen, Bjørn Munro; Grandjean, Philippe (2011): Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds. Ecotoxicology and Environmental Safety, 74(1), 157-163, https://doi.org/10.1016/j.ecoenv.2010.08.040 |
op_relation |
https://doi.pangaea.de/10.1594/PANGAEA.812009 https://doi.org/10.1594/PANGAEA.812009 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1594/PANGAEA.81200910.1016/j.ecoenv.2010.08.040 |
_version_ |
1810438439474036736 |