Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners
Summary: Serum 25(OH)D levels decline without sunlight exposure. We studied 120 expeditioners to Antarctica to determine the skeletal and hormonal responses to sunlight deprivation. With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was...
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ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.811580 2024-09-09T19:09:02+00:00 Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners Iuliano-Burns, Sandra Wang, X F Ayton, Jeff Jones, G Seeman, E 2009 application/zip, 2 datasets https://doi.pangaea.de/10.1594/PANGAEA.811580 https://doi.org/10.1594/PANGAEA.811580 en eng PANGAEA https://doi.pangaea.de/10.1594/PANGAEA.811580 https://doi.org/10.1594/PANGAEA.811580 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess Supplement to: Iuliano-Burns, Sandra; Wang, X F; Ayton, Jeff; Jones, G; Seeman, E (2009): Skeletal and hormonal responses to sunlight deprivation in Antarctic expeditioners. Osteoporosis International, 20(9), 1523-1528, https://doi.org/10.1007/s00198-008-0830-9 International Polar Year (2007-2008) IPY dataset publication series 2009 ftpangaea https://doi.org/10.1594/PANGAEA.81158010.1007/s00198-008-0830-9 2024-07-24T02:31:21Z Summary: Serum 25(OH)D levels decline without sunlight exposure. We studied 120 expeditioners to Antarctica to determine the skeletal and hormonal responses to sunlight deprivation. With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed. Baseline serum 25(OH)D levels >100 nmol/L prevented vitamin D insufficiency. Introduction: Vitamin D stores deplete without adequate sunlight exposure unless supplementation is provided. We studied 120 healthy adults who spent a year in Antarctica as a model for sunlight deprivation to define the timing and magnitude of the skeletal and hormonal responses to emerging vitamin D insufficiency. Methods: Fasting blood samples were assessed at baseline, 6 and 12 months for serum 25-hydroxyvitamin D (25(OH)D), osteocalcin (OC), bone formation (P1NP) and resorption (CTx), PTH and calcium. Lumbar spine and proximal femur BMD was measured using DXA. Differences over time were determined using repeated measures ANOVA. Percent changes were expressed as (Delta value/(value A +value B)/2)x100. Relationships between outcome measures were determined using Spearman's correlations. Results: Vitamin D insufficiency (<50 nmol/L) was observed in 85% of expeditioners by 6 months when serum calcium decreased and PTH increased (p<0.01). By 12 months, OC increased by 7.4±3.0% (p<0.05), and BMD decreased by 1.0±2.0% at the total proximal femur (p<0.05). For those with vitamin D sufficiency at baseline (>50 nmol/L), sunlight deprivation produced vitamin D insufficiency within 4 months unless baseline values were >100 nmol/L. Conclusion: Supplementation may be necessary for expeditioners with limited access to UV light. Other/Unknown Material Antarc* Antarctic Antarctica International Polar Year IPY PANGAEA - Data Publisher for Earth & Environmental Science Antarctic |
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Open Polar |
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PANGAEA - Data Publisher for Earth & Environmental Science |
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ftpangaea |
language |
English |
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International Polar Year (2007-2008) IPY |
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International Polar Year (2007-2008) IPY Iuliano-Burns, Sandra Wang, X F Ayton, Jeff Jones, G Seeman, E Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
topic_facet |
International Polar Year (2007-2008) IPY |
description |
Summary: Serum 25(OH)D levels decline without sunlight exposure. We studied 120 expeditioners to Antarctica to determine the skeletal and hormonal responses to sunlight deprivation. With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed. Baseline serum 25(OH)D levels >100 nmol/L prevented vitamin D insufficiency. Introduction: Vitamin D stores deplete without adequate sunlight exposure unless supplementation is provided. We studied 120 healthy adults who spent a year in Antarctica as a model for sunlight deprivation to define the timing and magnitude of the skeletal and hormonal responses to emerging vitamin D insufficiency. Methods: Fasting blood samples were assessed at baseline, 6 and 12 months for serum 25-hydroxyvitamin D (25(OH)D), osteocalcin (OC), bone formation (P1NP) and resorption (CTx), PTH and calcium. Lumbar spine and proximal femur BMD was measured using DXA. Differences over time were determined using repeated measures ANOVA. Percent changes were expressed as (Delta value/(value A +value B)/2)x100. Relationships between outcome measures were determined using Spearman's correlations. Results: Vitamin D insufficiency (<50 nmol/L) was observed in 85% of expeditioners by 6 months when serum calcium decreased and PTH increased (p<0.01). By 12 months, OC increased by 7.4±3.0% (p<0.05), and BMD decreased by 1.0±2.0% at the total proximal femur (p<0.05). For those with vitamin D sufficiency at baseline (>50 nmol/L), sunlight deprivation produced vitamin D insufficiency within 4 months unless baseline values were >100 nmol/L. Conclusion: Supplementation may be necessary for expeditioners with limited access to UV light. |
format |
Other/Unknown Material |
author |
Iuliano-Burns, Sandra Wang, X F Ayton, Jeff Jones, G Seeman, E |
author_facet |
Iuliano-Burns, Sandra Wang, X F Ayton, Jeff Jones, G Seeman, E |
author_sort |
Iuliano-Burns, Sandra |
title |
Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
title_short |
Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
title_full |
Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
title_fullStr |
Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
title_full_unstemmed |
Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners |
title_sort |
bone metabolic and hormonal characteristics of australian antarctic expeditioners |
publisher |
PANGAEA |
publishDate |
2009 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.811580 https://doi.org/10.1594/PANGAEA.811580 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctica International Polar Year IPY |
genre_facet |
Antarc* Antarctic Antarctica International Polar Year IPY |
op_source |
Supplement to: Iuliano-Burns, Sandra; Wang, X F; Ayton, Jeff; Jones, G; Seeman, E (2009): Skeletal and hormonal responses to sunlight deprivation in Antarctic expeditioners. Osteoporosis International, 20(9), 1523-1528, https://doi.org/10.1007/s00198-008-0830-9 |
op_relation |
https://doi.pangaea.de/10.1594/PANGAEA.811580 https://doi.org/10.1594/PANGAEA.811580 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1594/PANGAEA.81158010.1007/s00198-008-0830-9 |
_version_ |
1809823321535021056 |