(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland
The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as...
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Language: | English |
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PANGAEA
2008
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Online Access: | https://doi.pangaea.de/10.1594/PANGAEA.810194 https://doi.org/10.1594/PANGAEA.810194 |
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ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.810194 |
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record_format |
openpolar |
institution |
Open Polar |
collection |
PANGAEA - Data Publisher for Earth & Environmental Science |
op_collection_id |
ftpangaea |
language |
English |
topic |
3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene 4-hydroxy-heptachlorostyrene standard deviation alpha-Hexabromocyclododecane Chlordane Chlorinated benzene Dichlorodiphenyldichloroethylene Dieldrin East_Greenland East Greenland Hexabromocyclododecane Hexachlorocyclohexane Hydroxylated polybrominated biphenyl Hydroxylated polybrominated diphenyl ethers Hydroxy-polychlorinated biphenyl International Polar Year (2007-2008) IPY Lipids Methoxylated polybrominated diphenyl ethers Methyl sulfone polychlorinated biphenyl Mirex Octachlorostyrene para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol |
spellingShingle |
3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene 4-hydroxy-heptachlorostyrene standard deviation alpha-Hexabromocyclododecane Chlordane Chlorinated benzene Dichlorodiphenyldichloroethylene Dieldrin East_Greenland East Greenland Hexabromocyclododecane Hexachlorocyclohexane Hydroxylated polybrominated biphenyl Hydroxylated polybrominated diphenyl ethers Hydroxy-polychlorinated biphenyl International Polar Year (2007-2008) IPY Lipids Methoxylated polybrominated diphenyl ethers Methyl sulfone polychlorinated biphenyl Mirex Octachlorostyrene para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
topic_facet |
3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene 4-hydroxy-heptachlorostyrene standard deviation alpha-Hexabromocyclododecane Chlordane Chlorinated benzene Dichlorodiphenyldichloroethylene Dieldrin East_Greenland East Greenland Hexabromocyclododecane Hexachlorocyclohexane Hydroxylated polybrominated biphenyl Hydroxylated polybrominated diphenyl ethers Hydroxy-polychlorinated biphenyl International Polar Year (2007-2008) IPY Lipids Methoxylated polybrominated diphenyl ethers Methyl sulfone polychlorinated biphenyl Mirex Octachlorostyrene para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol |
description |
The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. |
format |
Dataset |
author |
Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
author_facet |
Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
author_sort |
Gebbink, Wouter A |
title |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
title_short |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
title_full |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
title_fullStr |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
title_full_unstemmed |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland |
title_sort |
(table 1) concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (ursus maritimus) from east greenland |
publisher |
PANGAEA |
publishDate |
2008 |
url |
https://doi.pangaea.de/10.1594/PANGAEA.810194 https://doi.org/10.1594/PANGAEA.810194 |
op_coverage |
LATITUDE: 74.000000 * LONGITUDE: -20.000000 |
long_lat |
ENVELOPE(-20.000000,-20.000000,74.000000,74.000000) |
genre |
East Greenland Greenland International Polar Year IPY Ursus maritimus |
genre_facet |
East Greenland Greenland International Polar Year IPY Ursus maritimus |
op_source |
Supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759, https://doi.org/10.1021/es071941f |
op_relation |
Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Rigét, Frank F; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environmental Pollution, 152(3), 621-629, https://doi.org/10.1016/j.envpol.2007.07.001 https://doi.pangaea.de/10.1594/PANGAEA.810194 https://doi.org/10.1594/PANGAEA.810194 |
op_rights |
CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1594/PANGAEA.81019410.1021/es071941f10.1016/j.envpol.2007.07.001 |
_version_ |
1810441758985682944 |
spelling |
ftpangaea:oai:pangaea.de:doi:10.1594/PANGAEA.810194 2024-09-15T18:04:15+00:00 (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J LATITUDE: 74.000000 * LONGITUDE: -20.000000 2008 text/tab-separated-values, 130 data points https://doi.pangaea.de/10.1594/PANGAEA.810194 https://doi.org/10.1594/PANGAEA.810194 en eng PANGAEA Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Rigét, Frank F; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environmental Pollution, 152(3), 621-629, https://doi.org/10.1016/j.envpol.2007.07.001 https://doi.pangaea.de/10.1594/PANGAEA.810194 https://doi.org/10.1594/PANGAEA.810194 CC-BY-3.0: Creative Commons Attribution 3.0 Unported Access constraints: unrestricted info:eu-repo/semantics/openAccess Supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759, https://doi.org/10.1021/es071941f 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene 4-hydroxy-heptachlorostyrene standard deviation alpha-Hexabromocyclododecane Chlordane Chlorinated benzene Dichlorodiphenyldichloroethylene Dieldrin East_Greenland East Greenland Hexabromocyclododecane Hexachlorocyclohexane Hydroxylated polybrominated biphenyl Hydroxylated polybrominated diphenyl ethers Hydroxy-polychlorinated biphenyl International Polar Year (2007-2008) IPY Lipids Methoxylated polybrominated diphenyl ethers Methyl sulfone polychlorinated biphenyl Mirex Octachlorostyrene para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol dataset 2008 ftpangaea https://doi.org/10.1594/PANGAEA.81019410.1021/es071941f10.1016/j.envpol.2007.07.001 2024-07-24T02:31:32Z The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. Dataset East Greenland Greenland International Polar Year IPY Ursus maritimus PANGAEA - Data Publisher for Earth & Environmental Science ENVELOPE(-20.000000,-20.000000,74.000000,74.000000) |