Effect of sulfite treatment on erythrocyte deformability in young and aged rats

• Published in: Toxicology Mechanisms and Methods
• Main Authors: Küçükatay, Vural, Erken, Gülten, Bor-Küçükatay, Melek, Kocamaz, ErdoÄŸan
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2009
• Subjects: hematological parameters; Aging; Erythrocyte aggregation; Erythrocyte deformability; Sulfite; animal cell; animal experiment; article; blood rheology; cell aging; cell membrane; cell shape; cell volume; erythrocyte lifespan; female; male; mean corpuscular hemoglobin; nonhuman; priority journal; rat; Wistar rat; Administration; Oral; Animals; Erythrocyte Indices; Hemoglobins; Rats; Wistar; Sulfites; Rattus; Rattus norvegicus; Rattus rattus
• Online Access: https://hdl.handle.net/11499/6913; https://doi.org/10.1080/15376510802175788

It is known that aging is associated with marked effects on integrity and function of cell membrane. These effects may also be exacerbated by exogenous chemicals, e.g. sulfite. Thus, the aim of this paper is to examine the influence of sulfite on hemorheological and related hematological parameters in rats of various ages. In this study, male Wistar rats at the age of 3 and 18 months were used and the following parameters were evaluated: Mean Cell Volume (MCV), Mean Corpuscular Hemoglobin Concentration (MCHC), Red blood Cell (RBC) deformability and aggregation. The results show that aging is associated with a decrease in RBC deformability and MCHC, an increase in MCV. Sulfite administration significantly increased RBC deformability in both young and aged rats. Although MCHC was decreased in young rats, it was increased in aged rats in response to sulfite exposure. Additionally, sulfite induced a decrement in MCV of aged rats. Neither aging nor sulfite treatment caused significant alterations in RBC aggregation parameters in all experimental groups. In conclusion, these findings suggest that RBC deformability impairs with age and sulfite has ameliorating effects on RBC deformability in both young and aged rats. Copyright © Informa UK Ltd.