The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats
The purpose of this study was to investigate the effects of hypercholesterolemia and sulphite on active avoidance learning. Male Wistar rats were divided into eight groups as follows: Control (C), Sulphite (S), Vitamin E (E), Sulphite + Vitamin E (SE), Hypercholesterolemia (H), Hypercholesterolemia...
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ftpamukkaleuniv:oai:acikerisim.pau.edu.tr:11499/8532 2023-05-15T18:05:30+02:00 The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats Ozsoy, O. Hacioglu, G. Savcioglu, F. Küçükatay, Vural Yargicoglu, P. Agar, A. orcid:0000-0002-6850-6281 2012 http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8532 English eng 10.1002/tox.20657 Environmental Toxicology Uluslararası Hakemli Dergi 15204081 (ISSN) http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8532 27 8 453 460 Scopus WOS PubMed info:eu-repo/semantics/closedAccess Active avoidance Hypercholesterolemia Lipid peroxidation Rat Sulphite Vitamin E Vitamin-E Mutagenesis Rats Toxic materials Sodium alpha tocopherol cholesterol nitrite sodium metabisulfite thiobarbituric acid reactive substance ecotoxicology health risk organic compound performance assessment rodent sulfite vitamin animal experiment animal tissue article avoidance behavior cholesterol blood level controlled study drug effect learning disorder male nonhuman priority journal Animals Antioxidants Avoidance Learning Hippocampus Nitrites Wistar Sulfites Thiobarbituric Acid Reactive Substances Rattus Rattus norvegicus Article 2012 ftpamukkaleuniv 2021-03-11T17:56:05Z The purpose of this study was to investigate the effects of hypercholesterolemia and sulphite on active avoidance learning. Male Wistar rats were divided into eight groups as follows: Control (C), Sulphite (S), Vitamin E (E), Sulphite + Vitamin E (SE), Hypercholesterolemia (H), Hypercholesterolemia + Sulphite (HS), Hypercholesterolemia + Vitamin E (HE), and Hypercholesterolemia + Sulphite + Vitamin E (HSE). At the end of the experimental period, the serum cholesterol level (mean ± SD) was significantly higher in H group (111.5 ± 11.11 mg dL-1) as compared to C group (63.5 ± 4.9 mg dL-1). Levels of thiobarbituric acid reactive substances (TBARS) were increased in HS group as compared to C, H, and S groups. Vitamin E reduced TBARS levels in HSE group compared with HS group. Active avoidance results indicated that hypercholesterolemia was associated with learning impairment. Our data clearly revealed that the combination of hypercholesterolemia and sulphite results in exaggerated impairment of active avoidance. Vitamin E improved active avoidance in HSE group compared with HS group. Therefore, the synergistic effect of hypercholesterolemia and sulphite may be associated with a considerable health risk. © 2010 Wiley Periodicals, Inc. Article in Journal/Newspaper Rattus rattus Pamukkale University Repository |
institution |
Open Polar |
collection |
Pamukkale University Repository |
op_collection_id |
ftpamukkaleuniv |
language |
English |
topic |
Active avoidance Hypercholesterolemia Lipid peroxidation Rat Sulphite Vitamin E Vitamin-E Mutagenesis Rats Toxic materials Sodium alpha tocopherol cholesterol nitrite sodium metabisulfite thiobarbituric acid reactive substance ecotoxicology health risk organic compound performance assessment rodent sulfite vitamin animal experiment animal tissue article avoidance behavior cholesterol blood level controlled study drug effect learning disorder male nonhuman priority journal Animals Antioxidants Avoidance Learning Hippocampus Nitrites Wistar Sulfites Thiobarbituric Acid Reactive Substances Rattus Rattus norvegicus |
spellingShingle |
Active avoidance Hypercholesterolemia Lipid peroxidation Rat Sulphite Vitamin E Vitamin-E Mutagenesis Rats Toxic materials Sodium alpha tocopherol cholesterol nitrite sodium metabisulfite thiobarbituric acid reactive substance ecotoxicology health risk organic compound performance assessment rodent sulfite vitamin animal experiment animal tissue article avoidance behavior cholesterol blood level controlled study drug effect learning disorder male nonhuman priority journal Animals Antioxidants Avoidance Learning Hippocampus Nitrites Wistar Sulfites Thiobarbituric Acid Reactive Substances Rattus Rattus norvegicus Ozsoy, O. Hacioglu, G. Savcioglu, F. Küçükatay, Vural Yargicoglu, P. Agar, A. The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
topic_facet |
Active avoidance Hypercholesterolemia Lipid peroxidation Rat Sulphite Vitamin E Vitamin-E Mutagenesis Rats Toxic materials Sodium alpha tocopherol cholesterol nitrite sodium metabisulfite thiobarbituric acid reactive substance ecotoxicology health risk organic compound performance assessment rodent sulfite vitamin animal experiment animal tissue article avoidance behavior cholesterol blood level controlled study drug effect learning disorder male nonhuman priority journal Animals Antioxidants Avoidance Learning Hippocampus Nitrites Wistar Sulfites Thiobarbituric Acid Reactive Substances Rattus Rattus norvegicus |
description |
The purpose of this study was to investigate the effects of hypercholesterolemia and sulphite on active avoidance learning. Male Wistar rats were divided into eight groups as follows: Control (C), Sulphite (S), Vitamin E (E), Sulphite + Vitamin E (SE), Hypercholesterolemia (H), Hypercholesterolemia + Sulphite (HS), Hypercholesterolemia + Vitamin E (HE), and Hypercholesterolemia + Sulphite + Vitamin E (HSE). At the end of the experimental period, the serum cholesterol level (mean ± SD) was significantly higher in H group (111.5 ± 11.11 mg dL-1) as compared to C group (63.5 ± 4.9 mg dL-1). Levels of thiobarbituric acid reactive substances (TBARS) were increased in HS group as compared to C, H, and S groups. Vitamin E reduced TBARS levels in HSE group compared with HS group. Active avoidance results indicated that hypercholesterolemia was associated with learning impairment. Our data clearly revealed that the combination of hypercholesterolemia and sulphite results in exaggerated impairment of active avoidance. Vitamin E improved active avoidance in HSE group compared with HS group. Therefore, the synergistic effect of hypercholesterolemia and sulphite may be associated with a considerable health risk. © 2010 Wiley Periodicals, Inc. |
author2 |
orcid:0000-0002-6850-6281 |
format |
Article in Journal/Newspaper |
author |
Ozsoy, O. Hacioglu, G. Savcioglu, F. Küçükatay, Vural Yargicoglu, P. Agar, A. |
author_facet |
Ozsoy, O. Hacioglu, G. Savcioglu, F. Küçükatay, Vural Yargicoglu, P. Agar, A. |
author_sort |
Ozsoy, O. |
title |
The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
title_short |
The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
title_full |
The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
title_fullStr |
The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
title_full_unstemmed |
The effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
title_sort |
effect of sodium metabisulphite on active avoidance performance in hypercholesterolemic rats |
publishDate |
2012 |
url |
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8532 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
10.1002/tox.20657 Environmental Toxicology Uluslararası Hakemli Dergi 15204081 (ISSN) http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8532 27 8 453 460 Scopus WOS PubMed |
op_rights |
info:eu-repo/semantics/closedAccess |
_version_ |
1766176977635508224 |