The impact of fatigue on patients with psoriatic arthritis: a

• Main Authors: Duruoz, MT, Gezer, HH, Nas, K, Kilic, E, Sargin, B, Kasman, SA, Alkan, H, Sahin, N, Cengiz, G, Cuzdan, N, Gezer, IA, Keskin, D, Mulkoglu, C, Resorlu, H, Ataman, S, Bal, A, Kucukakkas, O, Yurdakul, OV, Melikoglu, MA, Ayhan, FF, Baykul, M, Bodur, H, Calis, M, Capkin, E, Devrimsel, G, Gok, K, Hizmetli, S, Kamanli, A, Keskin, Y, Ecesoy, H, Kutluk, O, Sen, N, Sendur, OF, Tekeoglu, I, Tolu, S, Toprak, M, Tuncer, T
• Format: Article in Journal/Newspaper
• Language: English
• Published: SPRINGER HEIDELBERG 2020
• Subjects: Psoriatic arthritis; Fatigue; Lassitude; Disease activity; Outcome; measure; Okan; sami
• Online Access: http://hdl.handle.net/11499/38170

Fatigue is a substantial problem in patients with psoriatic arthritis (PsA) that needs to be considered in the core set of domains. This study aimed to evaluate fatigue and its relationship with disease parameters, functional disability, anxiety, depression, quality of life, and correlation with disease activity as determined by various scales. A total of 1028 patients (677 females, 351 males) with PsA who met the CASPAR criteria were included [Turkish League Against Rheumatism (TLAR) Network multicenter study]. The demographic features and clinical conditions of the patients were recorded. Correlations between fatigue score and clinical parameters were evaluated using the Disease Activity Score 28 (DAS28), Disease Activity in Psoriatic Arthritis (DAPSA), Clinical DAPSA (cDAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Fibromyalgia Rapid Screening Tool (FiRST), minimal disease activity (MDA), and very low disease activity (VLDA). Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy (FACIT-F) and a 10-point VAS (VAS-F). The mean age of the patients was 47 (SD: 12.2) years, and the mean disease duration was 6.4 (SD: 7.3) years. The mean VAS-F score was 5.1 (SD: 2.7), with fatigue being absent or mild, moderate, and severe in 12.8%, 24.6%, and 62.5% of the patients, respectively. Fatigue scores were significantly better in patients with DAS28 remission, DAPSA remission, cDAPSA remission, MDA, and VLDA (p < 0.001). Fatigue scores significantly increased with increasing disease activity levels on the DAS28, DAPSA, and cDAPSA (p < 0.001). VAS-F scores showed correlations with the scores of the BASDAI, BASFI, PsAQoL, HAD-A, FiRST, pain VAS, and PtGA. FiRST scores showed fibromyalgia in 255 (24.8%) patients. FACIT-F and VAS-F scores were significantly higher in patients with fibromyalgia (p < 0.001). In regression analysis, VLDA, BASDAI score, FiRST score, high education level, HAD-Anxiety, and BMI showed independent associations with fatigue. Our findings showed that fatigue was a common symptom in PsA and disease activity was the most substantial predictor, with fatigue being less in patients in remission, MDA, and VLDA. Other correlates of fatigue were female gender, educational level, anxiety, quality of life, function, pain, and fibromyalgia. C1 [Duruoz, Mehmet Tuncay; Gezer, Halise Hande; Acer Kasman, Sevtap] Marmara Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Istanbul, Turkey. [Nas, Kemal; Kamanli, Ayhan; Tekeoglu, Ibrahim] Sakarya Univ, Div Rheumatol & Immunol, Dept Phys Med & Rehabil, Sch Med, Sakarya, Turkey. [Kilic, Erkan] Kanuni Training & Res Hosp, Rheumatol Clin, Trabzon, Turkey. [Sargin, Betul] Adnan Menderes Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Aydin, Turkey. [Alkan, Hakan] Pamukkale Univ, Dept Phys Med & Rehabil, Sch Med, Denizli, Turkey. [Sahin, Nilay] Balikesir Univ, Dept Phys Med & Rehabil, Sch Med, Balikesir, Turkey. [Cengiz, Gizem; Calis, Mustafa] Erciyes Univ, Dept Phys Med & Rehabil, Sch Med, Div Rheumatol, Kayseri, Turkey. [Cengiz, Gizem] Van Training & Res Hosp, Rheumatol Clin, Van, Turkey. [Cuzdan, Nihan] Sanliurfa Training & Res Hosp, Rheumatol Clin, Sanliurfa, Turkey. [Albayrak Gezer, Ilknur] Selcuk Univ, Dept Phys Med & Rehabil, Sch Med, Konya, Turkey. [Keskin, Dilek] Kirikkale Univ, Dept Phys Med & Rehabil, Sch Med, Kirikkale, Turkey. [Mulkoglu, Cevriye; Ayhan, Fikriye Figen] Ankara Numune Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey. [Resorlu, Hatice] Canakkale Onsekiz Mart Univ, Dept Phys Med & Rehabil, Sch Med, Canakkale, Turkey. [Ataman, Sebnem] Ankara Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Ankara, Turkey. [Bal, Ajda] Ankara Diskapi Yildirim Beyazit Trainig & Res Hos, Univ Hlth Sci, Dept Phys Med & Rehabil, Ankara, Turkey. [Kucukakkas, Okan; Yurdakul, Ozan Volkan; Keskin, Yasar] Bezmialem Fdn Univ, Dept Phys Med & Rehabil, Istanbul, Turkey. [Melikoglu, Meltem Alkan] Ataturk Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Erzurum, Turkey. [Ayhan, Fikriye Figen] Usak Univ, High Sch Hlth Sci, Dept Phys Med & Rehabil, Usak, Turkey. [Baykul, Merve] Sakarya Univ, Dept Phys Med & Rehabil, Sch Med, Sakarya, Turkey. [Bodur, Hatice] Yildirim Beyazit Univ, Dept Phys Med & Rehabil, Sch Med, Ankara, Turkey. [Capkin, Erhan] Karadeniz Tech Univ, Dept Phys Med & Rehabil, Sch Med, Trabzon, Turkey. [Devrimsel, Gul] Recep Tayyip Erdogan Univ, Dept Phys Med & Rehabil, Sch Med, Rize, Turkey. [Gok, Kevser] Ankara City Hosp, Rheumatol Clin, Ankara, Turkey. [Hizmetli, Sami] Cumhuriyet Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Sivas, Turkey. [Ecesoy, Hilal] Necmettin Erbakan Univ, Meram Sch Med, Div Rheumatol, Dept Phys & Rehabil, Konya, Turkey. [Kutluk, Oznur; Tuncer, Tiraje] Akdeniz Univ, Div Rheumatol, Dept Phys Med & Rehabil, Sch Med, Antalya, Turkey. [Sen, Nesrin] Kartal Dr Lutfi Kirdar Training & Res Hosp, Rheumatol Clin, Istanbul, Turkey. [Sendur, Omer Faruk] Adnan Menderes Univ, Dept Phys Med & Rehabil, Sch Med, Aydin, Turkey. [Tolu, Sena] Medipol Univ, Dept Phys Med & Rehabil, Sch Med, Istanbul, Turkey. [Toprak, Murat] Yuzuncu Yil Univ, Dept Phys Med & Rehabil, Sch Med, Van, Turkey.