Nuclear Medicine Program progress report for quarter ending December 31, 1989

• Main Authors: Knapp, F.F. Jr., Ambrose, K.R., Callahan, A.P., McPherson, D.W., Mirzadeh, S., Srivastava, P.C., Allred, J.F., Hasan, A., Lambert, C.R., Lambert, S.J., Rice, D.E.
• Language: unknown
• Published: 2020
• Subjects: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARBAZONES; ABSORPTIVITY; COPPER COMPLEXES; MONOCARBOXYLIC ACIDS; IODINATION; ORGANIC SULFUR COMPOUNDS; RADIOPHARMACEUTICALS; SYNTHESIS; ANTIBODIES; AQUEOUS SOLUTIONS; COPPER 64; COPPER 67; IN VIVO; IRIDIUM 191; NUCLEAR MEDICINE; OSMIUM 191; PROGRESS REPORT; RADIOASSAY; RADIOCHEMISTRY; RADIOIMMUNOLOGY; RATS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHEMISTRY; COMPLEXES; COPPER ISOTOPES; DAYS LIVING RADIOISOTOPES; DISPERSIONS; DOCUMENT TYPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HALOGENATION; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; IRIDIUM ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; Carbonic acid
• Online Access: http://www.osti.gov/servlets/purl/7026860; https://www.osti.gov/biblio/7026860; https://doi.org/10.2172/7026860

In this report the use of a simple colorimetric assay employing the bisthiosemicarbazone (TSC) derivative of phenylglyoxal to evaluate the specific activity of spallation-produced copper-67 (Cu-67) samples is described. Four samples from the Los Alamos National Laboratory (LANL) and one sample from the Brookhaven National Laboratory (BNL) were analyzed and the results compared in a blind study'' with specific activity values obtained by isotope coupling plasma (ICP) analysis at the production sites. A good comparison was found, and these results indicate that the TSC approach is a simple, inexpensive, and rapid technique to determine the specific activity of spallation-produced Cu-67. The synthesis, radioiodination, and evaluation of deiodination in rats in vivo of two new maleimide agents for antibody labeling is also described. 3 figs., 1 tab.