Nuclear Medicine Program progress report for quarter ending December 31, 1989

In this report the use of a simple colorimetric assay employing the bisthiosemicarbazone (TSC) derivative of phenylglyoxal to evaluate the specific activity of spallation-produced copper-67 (Cu-67) samples is described. Four samples from the Los Alamos National Laboratory (LANL) and one sample from...

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Bibliographic Details
Main Authors: Knapp, F.F. Jr., Ambrose, K.R., Callahan, A.P., McPherson, D.W., Mirzadeh, S., Srivastava, P.C., Allred, J.F., Hasan, A., Lambert, C.R., Lambert, S.J., Rice, D.E.
Language:unknown
Published: 2020
Subjects:
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBAZONES
ABSORPTIVITY
COPPER COMPLEXES
MONOCARBOXYLIC ACIDS
IODINATION
ORGANIC SULFUR COMPOUNDS
RADIOPHARMACEUTICALS
SYNTHESIS
ANTIBODIES
AQUEOUS SOLUTIONS
COPPER 64
COPPER 67
IN VIVO
IRIDIUM 191
NUCLEAR MEDICINE
OSMIUM 191
PROGRESS REPORT
RADIOASSAY
RADIOCHEMISTRY
RADIOIMMUNOLOGY
RATS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHEMISTRY
COMPLEXES
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HALOGENATION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
Carbonic acid
Online Access:http://www.osti.gov/servlets/purl/7026860
https://www.osti.gov/biblio/7026860
https://doi.org/10.2172/7026860
Description
Summary:In this report the use of a simple colorimetric assay employing the bisthiosemicarbazone (TSC) derivative of phenylglyoxal to evaluate the specific activity of spallation-produced copper-67 (Cu-67) samples is described. Four samples from the Los Alamos National Laboratory (LANL) and one sample from the Brookhaven National Laboratory (BNL) were analyzed and the results compared in a blind study'' with specific activity values obtained by isotope coupling plasma (ICP) analysis at the production sites. A good comparison was found, and these results indicate that the TSC approach is a simple, inexpensive, and rapid technique to determine the specific activity of spallation-produced Cu-67. The synthesis, radioiodination, and evaluation of deiodination in rats in vivo of two new maleimide agents for antibody labeling is also described. 3 figs., 1 tab.

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