Drug metabolizing enzyme systems and their relationship to toxic mechanisms
The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.
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2008
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| Online Access: | http://www.osti.gov/servlets/purl/5010978-JFjXbC/ |
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ftosti:oai:osti.gov:5010978 |
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ftosti:oai:osti.gov:5010978 2023-05-15T15:52:34+02:00 Drug metabolizing enzyme systems and their relationship to toxic mechanisms Boyd, M.R.; Ravindranath, V.; Burka, L.T.; Dutcher, J.S.; Franklin, R.B.; Statham, C.N.; Haschek, W.M.; Hakkinen, P.J.; Morse, C.C.; Witschi, H.P. 2008-09-02 application/pdf http://www.osti.gov/servlets/purl/5010978-JFjXbC/ unknown http://www.osti.gov/servlets/purl/5010978-JFjXbC/ 63 RADIATION THERMAL AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. 59 BASIC BIOLOGICAL SCIENCES FURANS METABOLIC ACTIVATION TOXICITY MIXED-FUNCTION OXIDASES ENZYME ACTIVITY SEMICARBAZONES LIQUID COLUMN CHROMATOGRAPHY AUTORADIOGRAPHY CELL PROLIFERATION GEL PERMEATION CHROMATOGRAPHY GLUTATHIONE CONJUGATES KIDNEYS LIVER LUNGS MICE PATHOLOGICAL CHANGES ANIMALS BODY CARBONIC ACID DERIVATIVES CHROMATOGRAPHY DIGESTIVE SYSTEM ENZYMES GLANDS HETEROCYCLIC COMPOUNDS MAMMALS METABOLITES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDOREDUCTASES OXYGENASES RESPIRATORY SYSTEM RODENTS SEPARATION PROCESSES VERTEBRATES 2008 ftosti 2010-02-15T12:05:45Z The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs. Other/Unknown Material Carbonic acid SciTec Connect (Office of Scientific and Technical Information - OSTI, U.S. Department of Energy) |
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Open Polar |
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SciTec Connect (Office of Scientific and Technical Information - OSTI, U.S. Department of Energy) |
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ftosti |
| language |
unknown |
| topic |
63 RADIATION THERMAL AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. 59 BASIC BIOLOGICAL SCIENCES FURANS METABOLIC ACTIVATION TOXICITY MIXED-FUNCTION OXIDASES ENZYME ACTIVITY SEMICARBAZONES LIQUID COLUMN CHROMATOGRAPHY AUTORADIOGRAPHY CELL PROLIFERATION GEL PERMEATION CHROMATOGRAPHY GLUTATHIONE CONJUGATES KIDNEYS LIVER LUNGS MICE PATHOLOGICAL CHANGES ANIMALS BODY CARBONIC ACID DERIVATIVES CHROMATOGRAPHY DIGESTIVE SYSTEM ENZYMES GLANDS HETEROCYCLIC COMPOUNDS MAMMALS METABOLITES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDOREDUCTASES OXYGENASES RESPIRATORY SYSTEM RODENTS SEPARATION PROCESSES VERTEBRATES |
| spellingShingle |
63 RADIATION THERMAL AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. 59 BASIC BIOLOGICAL SCIENCES FURANS METABOLIC ACTIVATION TOXICITY MIXED-FUNCTION OXIDASES ENZYME ACTIVITY SEMICARBAZONES LIQUID COLUMN CHROMATOGRAPHY AUTORADIOGRAPHY CELL PROLIFERATION GEL PERMEATION CHROMATOGRAPHY GLUTATHIONE CONJUGATES KIDNEYS LIVER LUNGS MICE PATHOLOGICAL CHANGES ANIMALS BODY CARBONIC ACID DERIVATIVES CHROMATOGRAPHY DIGESTIVE SYSTEM ENZYMES GLANDS HETEROCYCLIC COMPOUNDS MAMMALS METABOLITES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDOREDUCTASES OXYGENASES RESPIRATORY SYSTEM RODENTS SEPARATION PROCESSES VERTEBRATES Boyd, M.R.; Ravindranath, V.; Burka, L.T.; Dutcher, J.S.; Franklin, R.B.; Statham, C.N.; Haschek, W.M.; Hakkinen, P.J.; Morse, C.C.; Witschi, H.P. Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| topic_facet |
63 RADIATION THERMAL AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. 59 BASIC BIOLOGICAL SCIENCES FURANS METABOLIC ACTIVATION TOXICITY MIXED-FUNCTION OXIDASES ENZYME ACTIVITY SEMICARBAZONES LIQUID COLUMN CHROMATOGRAPHY AUTORADIOGRAPHY CELL PROLIFERATION GEL PERMEATION CHROMATOGRAPHY GLUTATHIONE CONJUGATES KIDNEYS LIVER LUNGS MICE PATHOLOGICAL CHANGES ANIMALS BODY CARBONIC ACID DERIVATIVES CHROMATOGRAPHY DIGESTIVE SYSTEM ENZYMES GLANDS HETEROCYCLIC COMPOUNDS MAMMALS METABOLITES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDOREDUCTASES OXYGENASES RESPIRATORY SYSTEM RODENTS SEPARATION PROCESSES VERTEBRATES |
| description |
The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs. |
| author |
Boyd, M.R.; Ravindranath, V.; Burka, L.T.; Dutcher, J.S.; Franklin, R.B.; Statham, C.N.; Haschek, W.M.; Hakkinen, P.J.; Morse, C.C.; Witschi, H.P. |
| author_facet |
Boyd, M.R.; Ravindranath, V.; Burka, L.T.; Dutcher, J.S.; Franklin, R.B.; Statham, C.N.; Haschek, W.M.; Hakkinen, P.J.; Morse, C.C.; Witschi, H.P. |
| author_sort |
Boyd, M.R.; Ravindranath, V.; Burka, L.T.; Dutcher, J.S.; Franklin, R.B.; Statham, C.N.; Haschek, W.M.; Hakkinen, P.J.; Morse, C.C.; Witschi, H.P. |
| title |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_short |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_full |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_fullStr |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_full_unstemmed |
Drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| title_sort |
drug metabolizing enzyme systems and their relationship to toxic mechanisms |
| publishDate |
2008 |
| url |
http://www.osti.gov/servlets/purl/5010978-JFjXbC/ |
| genre |
Carbonic acid |
| genre_facet |
Carbonic acid |
| op_relation |
http://www.osti.gov/servlets/purl/5010978-JFjXbC/ |
| _version_ |
1766387712845152256 |