Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences
Background Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population. Objectives To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort...
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Blackwell Science Ltd.
2015
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Online Access: | http://hdl.handle.net/10852/93815 http://urn.nb.no/URN:NBN:no-96370 https://doi.org/10.1111/bjd.13288 |
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ftoslouniv:oai:www.duo.uio.no:10852/93815 2024-09-30T14:45:12+00:00 Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences ENEngelskEnglishElevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie 2015-07-01T12:55:22Z http://hdl.handle.net/10852/93815 http://urn.nb.no/URN:NBN:no-96370 https://doi.org/10.1111/bjd.13288 EN eng Blackwell Science Ltd. http://urn.nb.no/URN:NBN:no-96370 Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie . Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences. British Journal of Dermatology. 2015, 172(2), 419-427 http://hdl.handle.net/10852/93815 1251941 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British Journal of Dermatology&rft.volume=172&rft.spage=419&rft.date=2015 British Journal of Dermatology 172 2 419 427 https://doi.org/10.1111/bjd.13288 URN:NBN:no-96370 Fulltext https://www.duo.uio.no/bitstream/handle/10852/93815/1/article49535.pdf Attribution-NonCommercial 4.0 International https://creativecommons.org/licenses/by-nc/4.0/ 0007-0963 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2015 ftoslouniv https://doi.org/10.1111/bjd.13288 2024-09-12T05:44:04Z Background Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population. Objectives To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex. Methods A cross-sectional study including 10 521 participants aged 30–79 years from the Tromsø Study cohort was performed; 1137 participants reported lifetime psoriasis of a mainly mild character. The new harmonized definition of metabolic syndrome was used in the multivariable logistic regression analysis. Results There was a uniformly higher prevalence of metabolic syndrome in men and women with psoriasis compared with those without across all age groups. In women, psoriasis was associated with a 3·8-times higher odds of metabolic syndrome at age 30 years (95% confidence interval 1·5–9·7), with a decreasing odds ratio with increasing age. In men, psoriasis was associated with a stable 1·35-times higher odds of metabolic syndrome (95% confidence interval 1·1–1·6) at all ages. Abdominal obesity was the most frequent metabolic syndrome component in women in this study, and there was indication of a dose–response relationship between psoriasis severity, indicated through treatment, and having a high waistline in women. Conclusions This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø British Journal of Dermatology 172 2 419 427 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Background Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population. Objectives To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex. Methods A cross-sectional study including 10 521 participants aged 30–79 years from the Tromsø Study cohort was performed; 1137 participants reported lifetime psoriasis of a mainly mild character. The new harmonized definition of metabolic syndrome was used in the multivariable logistic regression analysis. Results There was a uniformly higher prevalence of metabolic syndrome in men and women with psoriasis compared with those without across all age groups. In women, psoriasis was associated with a 3·8-times higher odds of metabolic syndrome at age 30 years (95% confidence interval 1·5–9·7), with a decreasing odds ratio with increasing age. In men, psoriasis was associated with a stable 1·35-times higher odds of metabolic syndrome (95% confidence interval 1·1–1·6) at all ages. Abdominal obesity was the most frequent metabolic syndrome component in women in this study, and there was indication of a dose–response relationship between psoriasis severity, indicated through treatment, and having a high waistline in women. Conclusions This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity. |
format |
Article in Journal/Newspaper |
author |
Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie |
spellingShingle |
Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
author_facet |
Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie |
author_sort |
Danielsen, Kjersti |
title |
Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
title_short |
Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
title_full |
Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
title_fullStr |
Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
title_full_unstemmed |
Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences |
title_sort |
elevated odds of metabolic syndrome in psoriasis: a population-based study of age and sex differences |
publisher |
Blackwell Science Ltd. |
publishDate |
2015 |
url |
http://hdl.handle.net/10852/93815 http://urn.nb.no/URN:NBN:no-96370 https://doi.org/10.1111/bjd.13288 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
0007-0963 |
op_relation |
http://urn.nb.no/URN:NBN:no-96370 Danielsen, Kjersti Wilsgaard, Tom Olsen, Anne Olaug Eggen, Anne Elise Olsen, Karina Cassano, P. A. Furberg, Anne-Sofie . Elevated odds of metabolic syndrome in psoriasis: A population-based study of age and sex differences. British Journal of Dermatology. 2015, 172(2), 419-427 http://hdl.handle.net/10852/93815 1251941 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British Journal of Dermatology&rft.volume=172&rft.spage=419&rft.date=2015 British Journal of Dermatology 172 2 419 427 https://doi.org/10.1111/bjd.13288 URN:NBN:no-96370 Fulltext https://www.duo.uio.no/bitstream/handle/10852/93815/1/article49535.pdf |
op_rights |
Attribution-NonCommercial 4.0 International https://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1111/bjd.13288 |
container_title |
British Journal of Dermatology |
container_volume |
172 |
container_issue |
2 |
container_start_page |
419 |
op_container_end_page |
427 |
_version_ |
1811646009571278848 |