Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism
Background D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. Objec...
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ftoslouniv:oai:www.duo.uio.no:10852/92005 2023-05-15T18:34:47+02:00 Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris 2021 http://hdl.handle.net/10852/92005 http://urn.nb.no/URN:NBN:no-94600 https://doi.org/10.1016/j.thromres.2021.10.020 EN eng http://urn.nb.no/URN:NBN:no-94600 Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris . Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism. Thrombosis Research. 2021, 208, 121-126 http://hdl.handle.net/10852/92005 1966977 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Thrombosis Research&rft.volume=208&rft.spage=121&rft.date=2021 Thrombosis Research 208 121 126 https://doi.org/10.1016/j.thromres.2021.10.020 URN:NBN:no-94600 Fulltext https://www.duo.uio.no/bitstream/handle/10852/92005/1/D-dimer%2Band%2Bincident%2BVTE%2B-%2BCristin.pdf Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ CC-BY-NC-ND 0049-3848 Journal article Tidsskriftartikkel Peer reviewed AcceptedVersion 2021 ftoslouniv https://doi.org/10.1016/j.thromres.2021.10.020 2022-03-09T23:33:54Z Background D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. Objectives To investigate the association between plasma D-dimer levels and risk of future incident VTE. Methods A population-based nested case-control study, comprising 414 VTE patients and 843 randomly selected age- and sex-matched controls, was derived from the Tromsø Study (1994–2007). D-dimer was measured in plasma samples collected at cohort baseline (1994–95). Odds ratios (ORs) for VTE with 95% confidence intervals (CIs) were estimated according to quartile cut-offs of D-dimer levels determined in controls. Results The risk of VTE increased across quartiles of D-dimer levels (Ptrend = 0.014) in the age- and sex-adjusted model. Participants with plasma D-dimer levels in the highest quartile (≥152 ng/mL) had an OR for VTE of 1.65 (95% CI 1.14–2.40) compared with those in the lowest quartile (<94 ng/mL). The ORs were marginally attenuated after additional adjustment for body mass index (BMI) (OR 1.51, 95% CI 1.04–2.20) and C-reactive protein (CRP) (OR 1.34, 95% CI 0.90–1.98). Similar results were obtained for VTE subgroups, i.e. deep vein thrombosis, pulmonary embolism, and provoked/unprovoked events. Conclusion Our results indicate that elevated plasma D-dimer levels are associated with increased risk of incident VTE. However, the attenuation of risk estimates upon additional adjustment for BMI and CRP suggests that D-dimer partly reflects underlying conditions associated with obesity and an inflammatory state. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø Thrombosis Research 208 121 126 |
institution |
Open Polar |
collection |
Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
op_collection_id |
ftoslouniv |
language |
English |
description |
Background D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. Objectives To investigate the association between plasma D-dimer levels and risk of future incident VTE. Methods A population-based nested case-control study, comprising 414 VTE patients and 843 randomly selected age- and sex-matched controls, was derived from the Tromsø Study (1994–2007). D-dimer was measured in plasma samples collected at cohort baseline (1994–95). Odds ratios (ORs) for VTE with 95% confidence intervals (CIs) were estimated according to quartile cut-offs of D-dimer levels determined in controls. Results The risk of VTE increased across quartiles of D-dimer levels (Ptrend = 0.014) in the age- and sex-adjusted model. Participants with plasma D-dimer levels in the highest quartile (≥152 ng/mL) had an OR for VTE of 1.65 (95% CI 1.14–2.40) compared with those in the lowest quartile (<94 ng/mL). The ORs were marginally attenuated after additional adjustment for body mass index (BMI) (OR 1.51, 95% CI 1.04–2.20) and C-reactive protein (CRP) (OR 1.34, 95% CI 0.90–1.98). Similar results were obtained for VTE subgroups, i.e. deep vein thrombosis, pulmonary embolism, and provoked/unprovoked events. Conclusion Our results indicate that elevated plasma D-dimer levels are associated with increased risk of incident VTE. However, the attenuation of risk estimates upon additional adjustment for BMI and CRP suggests that D-dimer partly reflects underlying conditions associated with obesity and an inflammatory state. |
format |
Article in Journal/Newspaper |
author |
Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris |
spellingShingle |
Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
author_facet |
Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris |
author_sort |
Hansen, Ellen-Sofie |
title |
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
title_short |
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
title_full |
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
title_fullStr |
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
title_full_unstemmed |
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism |
title_sort |
elevated plasma d-dimer levels are associated with risk of future incident venous thromboembolism |
publishDate |
2021 |
url |
http://hdl.handle.net/10852/92005 http://urn.nb.no/URN:NBN:no-94600 https://doi.org/10.1016/j.thromres.2021.10.020 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
0049-3848 |
op_relation |
http://urn.nb.no/URN:NBN:no-94600 Hansen, Ellen-Sofie Rinde, Fridtjof Balteskard Edvardsen, Magnus Hindberg, Kristian Latysheva, Nadezhda Aukrust, Pål Ueland, Thor Michelsen, Annika Elisabet Hansen, John Bjarne Brækkan, Sigrid Kufaas Morelli, Vania Maris . Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism. Thrombosis Research. 2021, 208, 121-126 http://hdl.handle.net/10852/92005 1966977 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Thrombosis Research&rft.volume=208&rft.spage=121&rft.date=2021 Thrombosis Research 208 121 126 https://doi.org/10.1016/j.thromres.2021.10.020 URN:NBN:no-94600 Fulltext https://www.duo.uio.no/bitstream/handle/10852/92005/1/D-dimer%2Band%2Bincident%2BVTE%2B-%2BCristin.pdf |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.thromres.2021.10.020 |
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Thrombosis Research |
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208 |
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121 |
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1766219711659376640 |