Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment
Objectives: Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA during the initial 24 months of modern treat-to-target therapy and predictors of fatigue after 24 mon...
Published in: | Annals of the Rheumatic Diseases |
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2021
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ftoslouniv:oai:www.duo.uio.no:10852/91904 2023-05-15T15:12:03+02:00 Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte 2021-12-14T13:56:19Z http://hdl.handle.net/10852/91904 http://urn.nb.no/URN:NBN:no-94562 https://doi.org/10.1136/annrheumdis-2021-220750 EN eng HighWire Press http://urn.nb.no/URN:NBN:no-94562 Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte . Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment. Annals of the Rheumatic Diseases. 2021 http://hdl.handle.net/10852/91904 1968390 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals of the Rheumatic Diseases&rft.volume=&rft.spage=&rft.date=2021 Annals of the Rheumatic Diseases 81 3 344 350 9 https://doi.org/10.1136/annrheumdis-2021-220750 URN:NBN:no-94562 Fulltext https://www.duo.uio.no/bitstream/handle/10852/91904/1/annrheumdis-2021-220750.full.pdf Attribution-NonCommercial 4.0 International https://creativecommons.org/licenses/by-nc/4.0/ CC-BY-NC 0003-4967 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2021 ftoslouniv https://doi.org/10.1136/annrheumdis-2021-220750 2022-03-09T23:33:52Z Objectives: Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA during the initial 24 months of modern treat-to-target therapy and predictors of fatigue after 24 months of follow-up. Methods: Data were obtained from the treat-to-target, tight control Aiming for Remission in Rheumatoid Arthritis: a Randomised Trial Examining the Benefit of Ultrasound in a Clinical Tight Control Regime (ARCTIC) trial. Fatigue was measured on a visual analogue scale (VAS) from 0 to 100 mm and defined as clinically relevant if VAS was ≥20 mm. Baseline predictors of fatigue at 24 months were analysed by multivariable logistic regression. Results: 205 patients with fatigue data at baseline and 24 months were included. Median (25th, 75th percentiles) symptom duration was 5.4 months (2.8, 10.4), fatigue VAS 37.0 mm (13.0, 62.0) and mean Disease Activity Score (DAS) 3.4 (SD 1.1) at baseline. Prevalence of fatigue declined from 69% at baseline to 38% at 24 months. Fewer swollen joints (OR 0.92, 95% CI 0.87 to 0.98, p=0.006), lower power Doppler ultrasound score (OR 0.95, 95% CI 0.90 to 0.99, p=0.027) and higher patient global assessment (PGA) (OR 1.03, 95% CI 1.01 to 1.04, p<0.001) increased the risk of clinically relevant fatigue at 24 months. Not achieving remission at 6 months was associated with a higher risk of reporting fatigue at 24 months. Conclusions: Fatigue in patients with early RA was prevalent at disease onset, with a rapid and sustained reduction during treatment. Low objective disease activity and high PGA at baseline were predictors of clinically relevant fatigue at 24 months. Article in Journal/Newspaper Arctic Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Arctic Annals of the Rheumatic Diseases 81 3 344 350 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Objectives: Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA during the initial 24 months of modern treat-to-target therapy and predictors of fatigue after 24 months of follow-up. Methods: Data were obtained from the treat-to-target, tight control Aiming for Remission in Rheumatoid Arthritis: a Randomised Trial Examining the Benefit of Ultrasound in a Clinical Tight Control Regime (ARCTIC) trial. Fatigue was measured on a visual analogue scale (VAS) from 0 to 100 mm and defined as clinically relevant if VAS was ≥20 mm. Baseline predictors of fatigue at 24 months were analysed by multivariable logistic regression. Results: 205 patients with fatigue data at baseline and 24 months were included. Median (25th, 75th percentiles) symptom duration was 5.4 months (2.8, 10.4), fatigue VAS 37.0 mm (13.0, 62.0) and mean Disease Activity Score (DAS) 3.4 (SD 1.1) at baseline. Prevalence of fatigue declined from 69% at baseline to 38% at 24 months. Fewer swollen joints (OR 0.92, 95% CI 0.87 to 0.98, p=0.006), lower power Doppler ultrasound score (OR 0.95, 95% CI 0.90 to 0.99, p=0.027) and higher patient global assessment (PGA) (OR 1.03, 95% CI 1.01 to 1.04, p<0.001) increased the risk of clinically relevant fatigue at 24 months. Not achieving remission at 6 months was associated with a higher risk of reporting fatigue at 24 months. Conclusions: Fatigue in patients with early RA was prevalent at disease onset, with a rapid and sustained reduction during treatment. Low objective disease activity and high PGA at baseline were predictors of clinically relevant fatigue at 24 months. |
format |
Article in Journal/Newspaper |
author |
Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte |
spellingShingle |
Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
author_facet |
Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte |
author_sort |
Holten, Karen |
title |
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
title_short |
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
title_full |
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
title_fullStr |
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
title_full_unstemmed |
Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
title_sort |
fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment |
publisher |
HighWire Press |
publishDate |
2021 |
url |
http://hdl.handle.net/10852/91904 http://urn.nb.no/URN:NBN:no-94562 https://doi.org/10.1136/annrheumdis-2021-220750 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
0003-4967 |
op_relation |
http://urn.nb.no/URN:NBN:no-94562 Holten, Karen Sundlisæter, Nina Beate Paulshus Lillegraven, Siri Sexton, Joseph Nordberg, Lena Kristine Bugge Moholt, Ellen Hammer, Hilde Berner Uhlig, Till Kvien, Tore Kristian Haavardsholm, Espen A. Aga, Anna-Birgitte . Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment. Annals of the Rheumatic Diseases. 2021 http://hdl.handle.net/10852/91904 1968390 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals of the Rheumatic Diseases&rft.volume=&rft.spage=&rft.date=2021 Annals of the Rheumatic Diseases 81 3 344 350 9 https://doi.org/10.1136/annrheumdis-2021-220750 URN:NBN:no-94562 Fulltext https://www.duo.uio.no/bitstream/handle/10852/91904/1/annrheumdis-2021-220750.full.pdf |
op_rights |
Attribution-NonCommercial 4.0 International https://creativecommons.org/licenses/by-nc/4.0/ |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1136/annrheumdis-2021-220750 |
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Annals of the Rheumatic Diseases |
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81 |
container_issue |
3 |
container_start_page |
344 |
op_container_end_page |
350 |
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1766342800040787968 |