Repositioning of the global epicentre of non-optimal cholesterol
Abstract High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can h...
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2021
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Online Access: | http://hdl.handle.net/10852/83859 http://urn.nb.no/URN:NBN:no-86590 https://doi.org/10.1038/s41586-020-2338-1 |
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Abstract High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health 4,5 . However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to ... |
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Article in Journal/Newspaper |
author |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant |
spellingShingle |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant Repositioning of the global epicentre of non-optimal cholesterol |
author_facet |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant |
author_sort |
Taddei, Cristina |
title |
Repositioning of the global epicentre of non-optimal cholesterol |
title_short |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full |
Repositioning of the global epicentre of non-optimal cholesterol |
title_fullStr |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full_unstemmed |
Repositioning of the global epicentre of non-optimal cholesterol |
title_sort |
repositioning of the global epicentre of non-optimal cholesterol |
publishDate |
2021 |
url |
http://hdl.handle.net/10852/83859 http://urn.nb.no/URN:NBN:no-86590 https://doi.org/10.1038/s41586-020-2338-1 |
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Greenland Pacific Norway |
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Greenland Pacific Norway |
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Greenland Iceland |
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Greenland Iceland |
op_source |
0028-0836 |
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http://urn.nb.no/URN:NBN:no-86590 Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant . Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020, 582, 73-77 http://hdl.handle.net/10852/83859 1886749 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=582&rft.spage=73&rft.date=2020 Nature 582 7810 73 77 https://doi.org/10.1038/s41586-020-2338-1 URN:NBN:no-86590 Fulltext https://www.duo.uio.no/bitstream/handle/10852/83859/1/s41586-020-2338-1.pdf |
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Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
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https://doi.org/10.1038/s41586-020-2338-1 |
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ftoslouniv:oai:www.duo.uio.no:10852/83859 2024-09-30T14:36:01+00:00 Repositioning of the global epicentre of non-optimal cholesterol Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant 2021-02-04T14:38:47Z http://hdl.handle.net/10852/83859 http://urn.nb.no/URN:NBN:no-86590 https://doi.org/10.1038/s41586-020-2338-1 EN eng http://urn.nb.no/URN:NBN:no-86590 Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Ahmed, Soheir H Andersen, Lars Bo Anderssen, Sigmund Alfred Ariansen, Inger Kristine Holtermann Bjertness, Espen Bjertness, Marius Bergsmark Graff-Iversen, Sidsel Haugsgjerd, Teresa Risan Janszky, Imre Krokstad, Steinar Laugsand, Lars Erik Madar, Ahmed Ali Mathiesen, Ellisiv B. Meyer, Haakon E Sen, Abhijit Tell, Grete S. Vatten, Lars Johan Wilsgaard, Tom Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria L. C. Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young-Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant . Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020, 582, 73-77 http://hdl.handle.net/10852/83859 1886749 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=582&rft.spage=73&rft.date=2020 Nature 582 7810 73 77 https://doi.org/10.1038/s41586-020-2338-1 URN:NBN:no-86590 Fulltext https://www.duo.uio.no/bitstream/handle/10852/83859/1/s41586-020-2338-1.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ 0028-0836 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2021 ftoslouniv https://doi.org/10.1038/s41586-020-2338-1 2024-09-12T05:44:03Z Abstract High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health 4,5 . However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to ... Article in Journal/Newspaper Greenland Iceland Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Greenland Pacific Norway Nature 582 7810 73 77 |