Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds
Background Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods Population-based survey dat...
Published in: | BMC Cardiovascular Disorders |
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ftoslouniv:oai:www.duo.uio.no:10852/78366 2023-05-15T18:34:00+02:00 Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew 2020-04-30T17:30:40Z http://hdl.handle.net/10852/78366 http://urn.nb.no/URN:NBN:no-81471 https://doi.org/10.1186/s12872-020-01407-2 EN eng http://urn.nb.no/URN:NBN:no-81471 Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew . Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds. BMC Cardiovascular Disorders. 2020, 20:135, 1-11 http://hdl.handle.net/10852/78366 1808962 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC Cardiovascular Disorders&rft.volume=20:135&rft.spage=1&rft.date=2020 BMC Cardiovascular Disorders 20 1 https://doi.org/10.1186/s12872-020-01407-2 URN:NBN:no-81471 Fulltext https://www.duo.uio.no/bitstream/handle/10852/78366/1/article44781.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 1471-2261 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2020 ftoslouniv https://doi.org/10.1186/s12872-020-01407-2 2020-08-19T22:30:00Z Background Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods Population-based survey data on 40–69 year olds with hypertension defined as taking antihypertensives and/or having high blood pressure (140+/90+ mmHg) were obtained from Know Your Heart Study (KYH, N = 2284), Russian Federation (2015–2018) and seventh wave of The Tromsø Study (Tromsø 7, N = 5939), Norway (2015–2016). Uncontrolled hypertension was studied in the subset taking antihypertensives (KYH: N = 1584; Tromsø 7: 2792)and defined as having high blood pressure (140+/90+ mmHg). Apparent treatment resistant hypertension (aTRH) was defined as individuals with uncontrolled hypertension on 3+ OR controlled on 4+ antihypertensive classes in the same subset. Results Among all those with hypertension regardless of treatment status, control of blood pressure was achieved in 22% of men (KYH and Tromsø 7), while among women it was 33% in Tromsø 7 and 43% in KYH. When the analysis was limited to those on treatment for hypertension, the percentage uncontrolled was higher in KYH (47.8%, CI 95 44.6–50.9%) than Tromsø 7 (38.2, 36.1–40.5%). The corresponding figures for aTRH were 9.8% (8.2–11.7%) and 5.7% (4.8–6.8%). Antihypertensive monotherapies were more common than combinations and used by 58% in Tromsø 7 and 44% in KYH. In both KYH and Tromsø 7, untreated hypertension was higher in men, those with no GP visit in the past year and problem drinkers. In both studies, aTRH was associated with older age, CVD history, obesity, and diabetes. In Tromsø 7, also male gender and any drinking. In KYH, also chronic kidney disease. Conclusion There is considerable scope for promoting combination therapies in line with European treatment guidelines in both study populations. The factors associated with untreated hypertension overlap with known correlates of treatment non-adherence and health check non-attendance. In contrast, aTRH was characterised by obesity and underlying comorbidities potentially complicating treatment. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Norway Tromsø BMC Cardiovascular Disorders 20 1 |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Background Uncontrolled hypertension is a major cardiovascular risk factor. We examined uncontrolled hypertension and differences in treatment regimens between a high-risk country, Russia, and low-risk Norway to gain better understanding of the underlying factors. Methods Population-based survey data on 40–69 year olds with hypertension defined as taking antihypertensives and/or having high blood pressure (140+/90+ mmHg) were obtained from Know Your Heart Study (KYH, N = 2284), Russian Federation (2015–2018) and seventh wave of The Tromsø Study (Tromsø 7, N = 5939), Norway (2015–2016). Uncontrolled hypertension was studied in the subset taking antihypertensives (KYH: N = 1584; Tromsø 7: 2792)and defined as having high blood pressure (140+/90+ mmHg). Apparent treatment resistant hypertension (aTRH) was defined as individuals with uncontrolled hypertension on 3+ OR controlled on 4+ antihypertensive classes in the same subset. Results Among all those with hypertension regardless of treatment status, control of blood pressure was achieved in 22% of men (KYH and Tromsø 7), while among women it was 33% in Tromsø 7 and 43% in KYH. When the analysis was limited to those on treatment for hypertension, the percentage uncontrolled was higher in KYH (47.8%, CI 95 44.6–50.9%) than Tromsø 7 (38.2, 36.1–40.5%). The corresponding figures for aTRH were 9.8% (8.2–11.7%) and 5.7% (4.8–6.8%). Antihypertensive monotherapies were more common than combinations and used by 58% in Tromsø 7 and 44% in KYH. In both KYH and Tromsø 7, untreated hypertension was higher in men, those with no GP visit in the past year and problem drinkers. In both studies, aTRH was associated with older age, CVD history, obesity, and diabetes. In Tromsø 7, also male gender and any drinking. In KYH, also chronic kidney disease. Conclusion There is considerable scope for promoting combination therapies in line with European treatment guidelines in both study populations. The factors associated with untreated hypertension overlap with known correlates of treatment non-adherence and health check non-attendance. In contrast, aTRH was characterised by obesity and underlying comorbidities potentially complicating treatment. |
format |
Article in Journal/Newspaper |
author |
Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew |
spellingShingle |
Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
author_facet |
Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew |
author_sort |
Petersen, Jakob |
title |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_short |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_full |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_fullStr |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_full_unstemmed |
Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds |
title_sort |
uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of russian and norwegian 40–69 year olds |
publishDate |
2020 |
url |
http://hdl.handle.net/10852/78366 http://urn.nb.no/URN:NBN:no-81471 https://doi.org/10.1186/s12872-020-01407-2 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
1471-2261 |
op_relation |
http://urn.nb.no/URN:NBN:no-81471 Petersen, Jakob Malyutina, Sofia Ryabikov, Andrey Kontsevaya, Anna Kudryavtsev, Alexander V Eggen, Anne Elise McKee, Martin Cook, Sarah Anne Hopstock, Laila Arnesdatter Schirmer, Henrik Leon, David Adrew . Uncontrolled and apparent treatment-resistant hypertension: a cross-sectional study of Russian and Norwegian 40–69 year olds. BMC Cardiovascular Disorders. 2020, 20:135, 1-11 http://hdl.handle.net/10852/78366 1808962 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC Cardiovascular Disorders&rft.volume=20:135&rft.spage=1&rft.date=2020 BMC Cardiovascular Disorders 20 1 https://doi.org/10.1186/s12872-020-01407-2 URN:NBN:no-81471 Fulltext https://www.duo.uio.no/bitstream/handle/10852/78366/1/article44781.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12872-020-01407-2 |
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