Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance
Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. Methods...
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ftoslouniv:oai:www.duo.uio.no:10852/77583 2023-05-15T18:34:50+02:00 Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert 2019-10-21T13:56:47Z http://hdl.handle.net/10852/77583 http://urn.nb.no/URN:NBN:no-80701 https://doi.org/10.1002/ejp.1437 EN eng http://urn.nb.no/URN:NBN:no-80701 Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert . Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance. European Journal of Pain. 2019, 23(9), 1608-1618 http://hdl.handle.net/10852/77583 1739083 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Pain&rft.volume=23&rft.spage=1608&rft.date=2019 European Journal of Pain 23 9 1608 1618 https://doi.org/10.1002/ejp.1437 URN:NBN:no-80701 Fulltext https://www.duo.uio.no/bitstream/handle/10852/77583/4/Jacobsen_2019_Neu.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 1090-3801 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2019 ftoslouniv https://doi.org/10.1002/ejp.1437 2020-07-08T22:29:15Z Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. Methods This was a cross‐sectional study nested within the Tromsø‐6 survey. Neuropsychological test performance and the cold pressor test were investigated in 4,623 participants. Due to significant interaction with age, participants were divided into three age groups (<60, ≥60 to <70 and ≥70 years). Cox proportional hazard models assessed the relationship between neuropsychological tests and cold pressure pain tolerance, using hand‐withdrawal as event. The fully adjusted models controlled for sex, education, BMI, smoking status, exercise, systolic blood pressure, sleep problems and mental distress. Results In the adjusted models, participants aged ≥70 years showed a decreased hazard of hand withdrawal of 18% (HR 0.82, 95% CI (0.73, 0.92) per standard deviation on immediate verbal recall, and a decreased hazard of 23% (HR 0.77, 95% CI (0.65, 0.08) per standard deviation on psychomotor speed. Participants aged ≥60 to <70 years had a significant decreased hazard of 11% (HR 0.89, 95% CI (0.80, 0.98) per standard deviation on immediate word recall. In participants aged <60 years, there was a decreased hazard of 14% (HR 0.86 95% CI: 0.76, 0.98), per standard deviation on psychomotor speed. Conclusion Better performance on neuropsychological tests increased pain tolerance on the cold pressor test. These exposure effects were present in all age groups. Significance This paper describes substantial associations between cognitive functioning and cold pressor tolerance in 4,623 participants. Reduced psychomotor speed and poor verbal recall gave greater odds for hand‐withdrawal on the cold pressor task. The associations were stronger in older participants, indicating an interaction with age. Article in Journal/Newspaper Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Tromsø European Journal of Pain 23 9 1608 1618 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
op_collection_id |
ftoslouniv |
language |
English |
description |
Background Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests was associated with pain tolerance, controlling for salient confounders. Methods This was a cross‐sectional study nested within the Tromsø‐6 survey. Neuropsychological test performance and the cold pressor test were investigated in 4,623 participants. Due to significant interaction with age, participants were divided into three age groups (<60, ≥60 to <70 and ≥70 years). Cox proportional hazard models assessed the relationship between neuropsychological tests and cold pressure pain tolerance, using hand‐withdrawal as event. The fully adjusted models controlled for sex, education, BMI, smoking status, exercise, systolic blood pressure, sleep problems and mental distress. Results In the adjusted models, participants aged ≥70 years showed a decreased hazard of hand withdrawal of 18% (HR 0.82, 95% CI (0.73, 0.92) per standard deviation on immediate verbal recall, and a decreased hazard of 23% (HR 0.77, 95% CI (0.65, 0.08) per standard deviation on psychomotor speed. Participants aged ≥60 to <70 years had a significant decreased hazard of 11% (HR 0.89, 95% CI (0.80, 0.98) per standard deviation on immediate word recall. In participants aged <60 years, there was a decreased hazard of 14% (HR 0.86 95% CI: 0.76, 0.98), per standard deviation on psychomotor speed. Conclusion Better performance on neuropsychological tests increased pain tolerance on the cold pressor test. These exposure effects were present in all age groups. Significance This paper describes substantial associations between cognitive functioning and cold pressor tolerance in 4,623 participants. Reduced psychomotor speed and poor verbal recall gave greater odds for hand‐withdrawal on the cold pressor task. The associations were stronger in older participants, indicating an interaction with age. |
format |
Article in Journal/Newspaper |
author |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert |
spellingShingle |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
author_facet |
Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert |
author_sort |
Jacobsen, Henrik Børsting |
title |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_short |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_full |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_fullStr |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_full_unstemmed |
Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
title_sort |
neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance |
publishDate |
2019 |
url |
http://hdl.handle.net/10852/77583 http://urn.nb.no/URN:NBN:no-80701 https://doi.org/10.1002/ejp.1437 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
1090-3801 |
op_relation |
http://urn.nb.no/URN:NBN:no-80701 Jacobsen, Henrik Børsting Stubhaug, Audun Schirmer, Henrik Landrø, Nils Inge Wilsgaard, Tom Mathiesen, Ellisiv B. Nielsen, Christopher Sivert . Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance. European Journal of Pain. 2019, 23(9), 1608-1618 http://hdl.handle.net/10852/77583 1739083 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Pain&rft.volume=23&rft.spage=1608&rft.date=2019 European Journal of Pain 23 9 1608 1618 https://doi.org/10.1002/ejp.1437 URN:NBN:no-80701 Fulltext https://www.duo.uio.no/bitstream/handle/10852/77583/4/Jacobsen_2019_Neu.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1002/ejp.1437 |
container_title |
European Journal of Pain |
container_volume |
23 |
container_issue |
9 |
container_start_page |
1608 |
op_container_end_page |
1618 |
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1766219773881876480 |