Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs
Background Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007,...
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ftoslouniv:oai:www.duo.uio.no:10852/73690 2023-05-15T17:43:25+02:00 Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M 2019-03-05T13:43:52Z http://hdl.handle.net/10852/73690 http://urn.nb.no/URN:NBN:no-76809 https://doi.org/10.1016/j.envres.2019.02.047 EN eng NFR/244298 FRAM/Flagship Hazardous substances http://urn.nb.no/URN:NBN:no-76809 Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M . Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs. Environmental Research. 2019 http://hdl.handle.net/10852/73690 1682389 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental Research&rft.volume=&rft.spage=&rft.date=2019 Environmental Research 172 684 692 https://doi.org/10.1016/j.envres.2019.02.047 URN:NBN:no-76809 Fulltext https://www.duo.uio.no/bitstream/handle/10852/73690/5/1-s2.0-S0013935119301240-main.pdf Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ CC-BY 0013-9351 Journal article Tidsskriftartikkel Peer reviewed PublishedVersion 2019 ftoslouniv https://doi.org/10.1016/j.envres.2019.02.047 2020-06-21T08:53:18Z Background Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) to model-estimated values. A second objective was to compare the repeated cross-sectional time trends with those observed in our previous longitudinal study using repeated individual measurements in older men from the same surveys. Methods Serum from 45 persons aged 30 years in each of the following years: 1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted concentrations of PCB-153 in each sampling year were derived using the emission-based CoZMoMAN model. Results The median decreases in summed serum POP concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were − 71%, − 81%, and − 86% for women and − 65%, − 77%, and − 87% for men, respectively. The overall time trend in predicted PCB-153 concentrations demonstrated agreement with the observed trend although model predictions were higher than the measured concentrations at all time points. Compared to our previous longitudinal study of repeated individual measurements in older men, similar although more prominent declines were observed in the younger cross-sectional samples. Discussion Observed declines in serum concentrations from 1986 to 2007 were substantial for legacy POPs in men and women at reproductive ages in Northern Norway and are generally consistent with previous longitudinal biomonitoring efforts in the study population. The measured concentrations and observed declines likely reflect a combination of recent and historic exposures. Small differences in time trends observed between the studies could be attributed to different study designs (i.e. the chosen age group or sex and cross-sectional versus repeated individual measurement sampling). Article in Journal/Newspaper Northern Norway Tromsø Universitet i Oslo: Digitale utgivelser ved UiO (DUO) Norway Tromsø Environmental Research 172 684 692 |
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Open Polar |
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Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
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ftoslouniv |
language |
English |
description |
Background Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) to model-estimated values. A second objective was to compare the repeated cross-sectional time trends with those observed in our previous longitudinal study using repeated individual measurements in older men from the same surveys. Methods Serum from 45 persons aged 30 years in each of the following years: 1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted concentrations of PCB-153 in each sampling year were derived using the emission-based CoZMoMAN model. Results The median decreases in summed serum POP concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were − 71%, − 81%, and − 86% for women and − 65%, − 77%, and − 87% for men, respectively. The overall time trend in predicted PCB-153 concentrations demonstrated agreement with the observed trend although model predictions were higher than the measured concentrations at all time points. Compared to our previous longitudinal study of repeated individual measurements in older men, similar although more prominent declines were observed in the younger cross-sectional samples. Discussion Observed declines in serum concentrations from 1986 to 2007 were substantial for legacy POPs in men and women at reproductive ages in Northern Norway and are generally consistent with previous longitudinal biomonitoring efforts in the study population. The measured concentrations and observed declines likely reflect a combination of recent and historic exposures. Small differences in time trends observed between the studies could be attributed to different study designs (i.e. the chosen age group or sex and cross-sectional versus repeated individual measurement sampling). |
format |
Article in Journal/Newspaper |
author |
Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M |
spellingShingle |
Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
author_facet |
Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M |
author_sort |
Nøst, Therese Haugdahl |
title |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
title_short |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
title_full |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
title_fullStr |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
title_full_unstemmed |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs |
title_sort |
time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in northern norway: measurements, mechanistic modeling and a comparison of study designs |
publishDate |
2019 |
url |
http://hdl.handle.net/10852/73690 http://urn.nb.no/URN:NBN:no-76809 https://doi.org/10.1016/j.envres.2019.02.047 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_source |
0013-9351 |
op_relation |
NFR/244298 FRAM/Flagship Hazardous substances http://urn.nb.no/URN:NBN:no-76809 Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M . Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs. Environmental Research. 2019 http://hdl.handle.net/10852/73690 1682389 info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental Research&rft.volume=&rft.spage=&rft.date=2019 Environmental Research 172 684 692 https://doi.org/10.1016/j.envres.2019.02.047 URN:NBN:no-76809 Fulltext https://www.duo.uio.no/bitstream/handle/10852/73690/5/1-s2.0-S0013935119301240-main.pdf |
op_rights |
Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1016/j.envres.2019.02.047 |
container_title |
Environmental Research |
container_volume |
172 |
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684 |
op_container_end_page |
692 |
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